{"id":9132,"date":"2017-01-15T13:38:26","date_gmt":"2017-01-15T04:38:26","guid":{"rendered":"http:\/\/seigi.accsnet.ne.jp\/sigh\/blog\/?p=9132"},"modified":"2021-12-24T09:35:48","modified_gmt":"2021-12-24T00:35:48","slug":"%e3%81%be%e3%81%9fstap%e5%86%8d%e7%8f%be%e3%81%ae%e8%ab%96%e6%96%87%ef%bc%9f%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/nbsigh2.com\/?p=9132","title":{"rendered":"STAP\u73fe\u8c61\u518d\u73fe\u306e\u8ad6\u6587\uff1f"},"content":{"rendered":"<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4929889\/\" target=\"_blank\" rel=\"noopener\">Takumi Takeuchi,1 Akiko Tonooka,2 Yumiko Okuno,1 Mami Hattori-Kato,1 and Koji Mikami1, Oct4B, CD90, and CD73 are upregulated in bladder tissue following electro-resection of the bladder, J Stem Cells Regen Med. 2016; 12(1): 10\u201315. <\/a>\u3068\u3044\u3046\u8ad6\u6587\u304c\u3067\u305f\u3002<br \/>\nIntroduction \u306e\u5192\u982d\u306b\u300cIn 2014, Obokata <em>et al<\/em>., reported\u3000&#8230;&#8230;\u3000pluripotency (STAP).\u300d\u3068\u3042\u308b\u306e\u3067\u64c1\u8b77\u3059\u308b\u65b9\u3005\u304c\u5927\u559c\u3073\u306e\u3088\u3046\u3060\u3002\u52ff\u8ad6\u3001\u3053\u306e\u5f8c\u306b\u8ab0\u3082\u518d\u73fe\u3067\u304d\u306a\u304b\u3063\u305f\u3051\u308c\u3069\u30a2\u30a4\u30c7\u30a2\u306b\u306f\u691c\u8a0e\u3059\u308b\u4fa1\u5024\u304c\u3042\u308b\u3068\u3059\u308b\u308f\u3051\u3060\u3002\u5e8f\u306e\u6587\u7ae0\u3060\u304b\u3089\u306d\u3002<br \/>\n\u8180\u80f1\u304c\u3093\u60a3\u8005\u3067\u3001\u5185\u8996\u93e1\u624b\u8853\u3067\u3042\u308b\u7d4c\u5c3f\u9053\u7684\u8180\u80f1\u816b\u760d\u96fb\u6c17\u5207\u9664\u8853\uff08transurethral electro resection of bladder tumor\uff1aTUR-Bt)\u306b\u3088\u308a\u304c\u3093\u306e\u90e8\u5206\u3092\u53d6\u308a\u9664\u3044\u305f\u5f8c\u3001\u518d\u5ea6\u624b\u8853\u90e8\u4f4d\u304b\u3089\u7d44\u7e54\uff08\u304c\u3093\u306f\u542b\u307e\u308c\u3066\u3044\u306a\u3044\uff09\u3092\u5207\u308a\u53d6\u308a\u3001\u514d\u75ab\u7d44\u7e54\u5316\u5b66\u67d3\u8272\u3092\u884c\u3063\u305f\u3089\uff18\u4f8b\u4e2d\uff14\u4f8b\u3067Oct4B\uff08Oct4A\u306e\u307b\u3046\u304c\u591a\u80fd\u6027\u3092\u793a\u3059\u3082\u306e\u3067Oct4B\u306f\u3061\u304c\u3046\u3089\u3057\u3044\uff09\u3092\u767a\u73fe\u3059\u308b\u7d30\u80de\u304c\u3001\u3059\u3079\u3066\u3067\u9593\u8449\u7cfb\u9593\u8cea\u7d30\u80de\uff08MSCs \uff09\u3092\u793a\u3059CD90\u3068 CD73\u3092\u767a\u73fe\u3059\u308b\u7d30\u80de\u304c\u3042\u308a\u3001\u767d\u8840\u7403\u7531\u6765\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3059CD45\u3092\u767a\u73fe\u3059\u308b\u7d30\u80de\u306f\u306a\u304b\u3063\u305f\u3001\u3068\u3044\u3046\u7d50\u679c\u3067\u3059\u3002<br \/>\n\u8180\u80f1\u306b\u4e0e\u3048\u305f\u96fb\u6c17\u523a\u6fc0\u304c\u9593\u8449\u7cfb\u9593\u8cea\u7d30\u80de\u3092\u96c6\u3081\u6d3b\u6027\u5316\u3057\u8180\u80f1\u4fee\u5fa9\u306b\u53c2\u52a0\u3057\u305f\u306e\u3067\u3042\u308d\u3046\u3001\u3068\u3044\u3046\u306e\u304c\u8003\u5bdf\u3067\u3059\u3002<br \/>\n\u300c<strong><span style=\"color: #ff0000;\">Not pluripotent stem cells<\/span><\/strong>, but the more downstream MSCs may be mainly involved in tissue repair of the bladder.\u3000\u591a\u80fd\u6027\u5e79\u7d30\u80de\u304c\u3067\u304d\u305f\u308f\u3051\u3067\u306f\u306a\u304f\u3001\u305d\u308c\u3088\u308a\u5206\u5316\u3057\u305f\u9593\u8449\u7cfb\u9593\u8cea\u7d30\u80de\u304c\u8180\u80f1\u4fee\u5fa9\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u306e\u3060\u308d\u3046\u300d\u3068\u3044\u3046\u7d50\u8ad6\u3067\u3059\u3002<br \/>\n\u3064\u307e\u308aSTAP\u73fe\u8c61\u306e\u518d\u73fe\u3067\u3082\u306a\u3093\u3067\u3082\u306a\u3044\u3067\u3059\u3002\u5f15\u7528\u3057\u3066\u3044\u306a\u3044\u3051\u3069<a href=\"http:\/\/www.stemcells.med.tohoku.ac.jp\/outline\/\" target=\"_blank\" rel=\"noopener\">\u00a0Multilineage-differentiateing Stress Enduring (Muse)\u7d30\u80de<\/a>\u306b\u8fd1\u3044\u306e\u3067\u306f\u306a\u3044\u3067\u3057\u3087\u3046\u304b\uff1f<br \/>\n\u3061\u306a\u307f\u306bSTAP\u7d30\u80de\u306e\u5f15\u7528\u306f\u4f8b\u306eNature\u306e\u8ad6\u6587\u3067\u306f\u306a\u304f\u3001\u518d\u73fe\u3067\u304d\u306a\u304b\u3063\u305f\u3088\u3068\u3044\u3046<a href=\"http:\/\/www.nature.com\/nature\/journal\/v525\/n7570\/full\/nature15513.html\">Alejandro De Los Angeles,\u2026..&amp; Q. Daley, Failure to replicate the STAP cell phenomenon, Nature 525, E6\u2013E9 (24 September 2015) doi:10.1038<\/a>\u00a0\u306e\u65b9\u3067\u3059\u3002\u3053\u308c\u304b\u3089\u307f\u3066\u3082\u3001\u3053\u306e\u8ad6\u6587\u306e\u8457\u8005\u7b49\u306fSTAP\u73fe\u8c61\u306e\u518d\u73fe\u3060\u306a\u3093\u3066\u601d\u3063\u3066\u3044\u306a\u3044\u3067\u3057\u3087\u3046\u306d\u3002\u4f8b\u306eNature\u3084\u535a\u58eb\u8ad6\u6587\u3067\u306f\u96fb\u6c17\u523a\u6fc0\u306f\u306a\u304b\u3063\u305f\u306f\u305a\u3060\u3057\u3002<br \/>\n\u306a\u3093\u3067STAP\u7d30\u80de\u3092\u5e8f\u306b\u3082\u3063\u3066\u304d\u305f\u3093\u3067\u3057\u3087\uff1fMUSE\u7d30\u80de\u306e\u307b\u3046\u304c\u3088\u304b\u3063\u305f\u306e\u3067\u306f\uff1f\u3067\u3082MUSE\u7d30\u80de\u3068\u540c\u3058\u304b\u3068\u8a00\u308f\u308c\u3061\u3083\u3046\u304b\u3089\u5f15\u7528\u3057\u306a\u304b\u3063\u305f\u306e\u304b\u306a\uff1f<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\t\t\t\t<![CDATA[]]>\t\t<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2,8],"tags":[],"class_list":["post-9132","post","type-post","status-publish","format-standard","hentry","category-education","category-fake"],"_links":{"self":[{"href":"https:\/\/nbsigh2.com\/index.php?rest_route=\/wp\/v2\/posts\/9132","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nbsigh2.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nbsigh2.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nbsigh2.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nbsigh2.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=9132"}],"version-history":[{"count":1,"href":"https:\/\/nbsigh2.com\/index.php?rest_route=\/wp\/v2\/posts\/9132\/revisions"}],"predecessor-version":[{"id":21535,"href":"https:\/\/nbsigh2.com\/index.php?rest_route=\/wp\/v2\/posts\/9132\/revisions\/21535"}],"wp:attachment":[{"href":"https:\/\/nbsigh2.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=9132"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nbsigh2.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=9132"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nbsigh2.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=9132"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}