{"id":9124,"date":"2017-01-11T17:59:49","date_gmt":"2017-01-11T08:59:49","guid":{"rendered":"http:\/\/seigi.accsnet.ne.jp\/sigh\/blog\/?p=9124"},"modified":"2021-12-24T09:34:43","modified_gmt":"2021-12-24T00:34:43","slug":"%e3%83%af%e3%83%88%e3%82%bd%e3%83%b3%e3%81%95%e3%82%93%e3%82%82%e7%9b%b8%e5%a4%89%e3%82%8f%e3%82%89%e3%81%9a%e3%81%ae%e3%82%88%e3%81%86%e3%81%a7","status":"publish","type":"post","link":"https:\/\/nbsigh2.com\/?p=9124","title":{"rendered":"\u30ef\u30c8\u30bd\u30f3\u3055\u3093\u3082\u76f8\u5909\u308f\u3089\u305a\u306e\u3088\u3046\u3067"},"content":{"rendered":"

\u5c0f\u4fdd\u65b9\u6674\u5b50\u3055\u3093\u3078\u306e\u4e0d\u6b63\u306a\u5831\u9053\u3092\u8ffd\u53ca\u3059\u308b\u6709\u5fd7\u306e\u4f1a<\/a>\u306f\u6728\u661f\u3055\u3093\u304c\u6c88\u6bbf\u3057\u3066\u3069\u3046\u306a\u308b\u3053\u3068\u304b\u3068\u601d\u3063\u3066\u3044\u305f\u3089\u76f8\u5909\u308f\u3089\u305a\u306e\u3088\u3046\u3067\u3059\u306d\u3002
\n2016\u5e7412\u670813\u65e5\u3000STAP\u4e8b\u4ef6\u306e\u6b63\u3057\u3044\u7406\u89e3\u3068\u306f\uff0d\u79d1\u5b66\u5553\u8499\u306b\u3064\u3044\u3066\u30fc\u306e\u30b3\u30e1\u30f3\u30c8\u6b04\u3067\u306f<\/a><\/p>\n

217. \u5357\u9752\u5c71 2017\u5e7401\u670810\u65e5 19:04
\n\u3057\u304b\u3082\u3001\u3053\u306e3\u5e74\u306e\u9593\u306b\u3001STAP\u7d30\u80de\u3001STAP\u73fe\u8c61\u306e\u5b9f\u5728\u3092\u508d\u8a3c\u3059\u308b\u6709\u529b\u306a\u7814\u7a76\u767a\u8868\u304c\u76f8\u6b21\u3044\u3067\u3044\u307e\u3059\u3002
\n\u2460\u30a2\u30e1\u30ea\u30ab\u30fb\u30c6\u30ad\u30b5\u30b9\u5927\u5b66\u30ad\u30f3\u30ac\u535a\u58eb\u3089\u306b\u3088\u308b\u300c\u640d\u50b7\u8a98\u5c0e\u6027\u306b\u3088\u308b\u7b4b\u8089\u7531\u6765\u306e\u5e79\u7d30\u80de\u69d8\u7d30\u80de\uff08iMuSCs\uff09\u300d\u8ad6\u6587\uff08\u300c2015\u5e7411\u670827\u65e5\uff09
\n\u2461\u30c9\u30a4\u30c4\u30fb\u30cf\u30a4\u30c7\u30eb\u30d9\u30eb\u30af\u5927\u5b66\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306b\u3088\u308b\u300cJurkatT\u7d30\u80de\u3092\u7528\u3044\u305fSTAP\u7d30\u80de\u518d\u73fe\u5b9f\u9a13\u300d\u8ad6\u6587\uff082016\u5e743\u670810\u65e5\uff09\u3002
\n\u2462\u5175\u5eab\u533b\u79d1\u5927\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u304c\u3001\u8133\u6897\u585e\u306e\u7d44\u7e54\u306e\u4e2d\u306b\u795e\u7d4c\u7d30\u80de\u3092\u4f5c\u308b\u7d30\u80de\uff08\u300ciSC\u7d30\u80de\uff08\u865a\u8840\u8a98\u5c0e\u6027\u591a\u80fd\u6027\u5e79\u7d30\u80de\uff09\u300d\uff09\u304c\u3042\u308b\u3053\u3068\u3092\u767a\u898b\uff082017\u5e741\u67085\u65e5\u65b0\u805e\u5831\u9053\uff09\u3002<\/p><\/blockquote>\n

\u300cSTAP\u73fe\u8c61\u304c\u518d\u73fe\u3055\u308c\u305f\u3001\u5175\u5eab\u533b\u79d1\u5927\u5b66\u3067\u3082\u660e\u3089\u304b\u306b\u3055\u308c\u305f\u300d\u306a\u3093\u3066\u76f8\u5909\u308f\u3089\u305a\u3067\u3059\u3002\u6728\u661f\u6c0f\u3084\u5927\u5b85\u306a\u3093\u3061\u3083\u3089\u304c\u66f8\u3044\u305f\u30c7\u30bf\u30e9\u30e1\u8a18\u4e8b\u3092\u4fe1\u3058\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u3002\u3061\u306a\u307f\u306b\u2460\u3068\u2461\u306fSTAP\u73fe\u8c61\u3067\u306f\u306a\u3044\u3068\u6563\u3005\u3044\u308f\u308c\u3066\u304d\u3066\u305f\u3068\u3053\u308d\u3067\u3059\u304c\u2462\u304c\u52a0\u308f\u3063\u305f\u69d8\u3067\u3059\u3002
\n\u2460\u3068\u306f
\nKinga Vojnits, HaiYing Pan, Xiaodong Mu & Yong Li, Characterization of an Injury Induced Population of Muscle-Derived Stem Cell-Like Cells, Scientific Reports 5, Article number: 17355 (2015), doi:10.1038\/srep17355<\/a>
\n\u306e\u3053\u3068\u3067\u3001\u3053\u306e\u8ad6\u6587\u306bSTAP\u306eS\u306e\u5b57\u3082\u3067\u3066\u3053\u306a\u3044\u3002Obokata, H. et al. The potential of stem cells in adult tissues representative of the three germ layers. Tissue Eng Part A 17, 607\u2013615 (2011).\u3092\u5f15\u7528\u3057\u3066\u3044\u308b\u304c\u3001\u5f15\u7528\u3057\u305f\u306e\u306fDiscussion \u306e\u5192\u982d\u306e\u300cThe existence of pluripotent-like cells in adult tissues has been a matter of debate for years, since inconsistent results have been reported by various groups9,10,11,12,13,14,15\u300d\u3067\u3001\u8981\u3059\u308b\u306b\u6210\u4f53\u306e\u7d44\u7e54\u306b\u591a\u80fd\u6027\u7d30\u80de\u304c\u5b58\u5728\u3059\u308b\u304b\u5426\u304b\u306f\u4f55\u5e74\u3082\u8b70\u8ad6\u306b\u306a\u3063\u3066\u3044\u308b\u3068\u3044\u3046\u4e00\u4f8b\u3067\u5f15\u7528\u3057\u3066\u3044\u308b\u3060\u3051\u3060\u3002\u9aa8\u683c\u7b4b\u304c\u5916\u50b7\u3092\u53d7\u3051\u308b\u3068\u591a\u80fd\u6027\u69d8\u306e\u7d30\u80demuscle-derived stem cell-like cells (iMuSCs) \u304c\u3067\u304d\u305f\u3068\u3044\u3046\u8ad6\u6587\u3060\u3002STAP\u306e\u8a3c\u660e\u3060\u3068\u3044\u3063\u305f\u3089Kinga Vojnits\u7b49\u306f\u6012\u308b\u3060\u308d\u3046\u3002
\n\u2461\u3068\u306f
\nJee Young Kim , Xinlai Cheng , Hamed Alborzinia , Stefan W\u00f6lfl, Modified STAP conditions facilitate bivalent fate decision between pluripotency and apoptosis in Jurkat T-lymphocytes, Biochemical and Biophysical Research Communications Volume 472, Issue 4, 15 April 2016, Pages 585\u2013591<\/a>
\n\u306e\u3053\u3068\u3067\u3001\u30bf\u30a4\u30c8\u30eb\u306bSTAP\u3068\u3042\u308b\u304c\u3001\u3072\u3068\u76ee\u3092\u5f15\u304f\u305f\u3081\u306b\u4f7f\u3063\u305f\u611f\u304c\u5426\u3081\u305a\u3001\u5185\u5bb9\u306f\u304c\u3093\u7d30\u80de\u306e\u7d99\u4ee3\u57f9\u990aLine\u3067\u3042\u308bJurkat T-lymphocytes\u3092\u9178\u51e6\u7406\u3057\u305f\u3089\u591a\u80fd\u6027\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308b alkaline phosphatase (AP) \u304c\u767a\u73fe\u3055\u308c\u305f\u3051\u3069\u3001 OCT4 \u306f\u51fa\u3066\u3053\u306a\u304b\u3063\u305f\u3088\u3068\u3044\u3046\u8ad6\u6587\u3067\u4f53\u7d30\u80de\u304c\u30b9\u30c8\u30ec\u30b9\u3067\u521d\u671f\u5316\u3055\u308c\u305f\u308f\u3051\u3067\u3082\u306a\u3044\u306e\u3067STAP\u73fe\u8c61\u304c\u51fa\u73fe\u3057\u305f\u308f\u3051\u3067\u3082\u306a\u3044\u3067\u3059\u306a\u3002
\n\u2462\u3068\u306f\u5175\u5eab\u533b\u79d1\u5927\u5b66\u306e\u8133\u795e\u7d4c\u5916\u79d1\u5b66 \u52a9\u6559 \u9ad9\u6728\u4fca\u7bc4\u6c0f\u306e\u8ad6\u6587\u3067
\nNakagomi T, Nakano-Doi A, Narita A, Matsuyama T. Concise Review: Are Stimulated Somatic Cells Truly Reprogrammed into ES\/iPS-like Pluripotent State? Better Understanding by Ischemia-induced Multipotent Stem Cells in a Mouse Model of Cerebral Infarction. Stem Cells International, Volume 2015, Article ID 630693, 2015.
\n\u306a\u3069\u306e\u8ad6\u6587\u3067\u3001\u8133\u6897\u585e\u3067\u767a\u751f\u3059\u308b\u3088\u3046\u306a\u4f4e\u9178\u7d20\u306b\u6652\u3059\u3068\u865a\u8840\u8a98\u5c0e\u6027\u591a\u80fd\u6027\u5e79\u7d30\u80de\uff1aiSCs(ischemia-induced multipotent stem cells)\u304c\u51fa\u73fe\u3057\u795e\u7d4c\u7d30\u80de\u3084\u30b0\u30ea\u30a2\u7d30\u80de\u304c\u518d\u751f\u3057\u3066\u304f\u308b\u3068\u3044\u3046\u8ad6\u6587\u3067\u3059\u3002\u5f53\u7136\u306e\u3053\u3068\u306a\u304c\u3089\u3001\u3053\u306e\u8ad6\u6587\u3084Nakagomi T, Nakano-Doi A, Narita A, Matsuyama T. \u3067Pub Med \u3067\u691c\u7d22\u3055\u308c\u308b\u95a2\u9023\u3059\u308b\u3082\u3046\uff12\u3064\u306e\u8ad6\u6587\u306bSTAP\u306eS \u3082Obokata \u306e\u6587\u5b57\u5217\u3082\u3042\u308a\u307e\u305b\u3093\u306a\u3002STAP\u73fe\u8c61\u306e\u518d\u73fe\u3060\u306a\u3093\u3066\u8a00\u3063\u305f\u3089\u9ad9\u6728\u4fca\u7bc4\u6c0f\u306f\u6012\u308b\u3067\u3057\u3087\u3046\u306a\u3002\u64a4\u56de\u3055\u308c\u305f\u8ad6\u6587\u3092\u5f15\u7528\u3059\u308b\u308f\u3051\u304c\u306a\u3044\u3067\u3059\u304b\u3089\u306a\u3002<\/p>\n

227. \u5357\u9752\u5c71 2017\u5e7401\u670811\u65e5 00:37
\n\u7121\u77e5\u306b\u3064\u3051\u308b\u85ac\u306f\u306a\u3044\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u306d\u3002
\nSTAP\u7d30\u80de\u3001STAP\u73fe\u8c61\u3092\u5426\u5b9a\u3057\u3088\u3046\u3068\u3059\u308b\u306e\u306f\u3053\u306e\u624b\u306e\u8f29\u3070\u304b\u308a\u3002
\n\u73fe\u5b9f\u3092\u76f4\u8996\u3067\u304d\u305a\u3001\u81ea\u5206\u306e\u982d\u306e\u4e2d\u306e\u5984\u60f3\u4e16\u754c\u306b\u6d78\u308a\u8fbc\u3093\u3067\u3044\u308b\u3060\u3051\u3002<\/p><\/blockquote>\n

\u3093\u304c\u3001\u73fe\u5b9f\u3092\u76f4\u8996\u3067\u304d\u306a\u3044\u3001\u5984\u60f3\u3060\u3051\u3068\u306f\u81ea\u5206\u306e\u3053\u3068\u3092\u8a00\u3063\u3066\u3044\u308b\u306e\u304b\uff1f
\n\u4e45\u3057\u3076\u308a\u306b\u3042\u306e\u30b3\u30e1\u30c7\u30a3\u30a2\u30f3\u30fb\u30ef\u30c8\u30bd\u30f3\u6c0f\u304c\u3067\u3066\u304d\u305f\u3088\u3002<\/p>\n

212. J\u30fb\u30ef\u30c8\u30bd\u30f3 2017\u5e7401\u670810\u65e5 13:22
\n\u300c\u30d0\u30ab\u30f3\u30c6\u30a3\u7814\u304c\u72ec\u308a\u5360\u3081\u300d\u3068\u8a00\u3063\u305f\u306e\u3067\u3059\u3088\u3002<\/p><\/blockquote>\n

\u304a\u304a\u3001\u3055\u3059\u304c\u30ef\u30c8\u30bd\u30f3\u6c0f\u3001\u30d0\u30ab\u30f3\u30c6\u30a3\u306e\u767a\u8a00\u3001\u201cI will go to my grave still being absolutely certain that it’s correct,<\/a>\u201d\uff08\u79c1\u306f\u307e\u3060\u305d\u308c\u304c\u6b63\u3057\u3044\u3053\u3068\u3092\u7d76\u5bfe\u306b\u78ba\u4fe1\u3057\u3066\u3044\u308b\u304b\u3089\u79c1\u306e\u5893\u307e\u3067\u6301\u3063\u3066\u3044\u304f\u3060\u308d\u3046\uff09\u3092\u3061\u3083\u3093\u3068\u61b6\u3048\u3066\u3044\u3089\u3063\u3057\u3083\u308b\u3088\u3046\u3067\u3059\u306a\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\t\t\t\t\t\t<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2,8],"tags":[],"class_list":["post-9124","post","type-post","status-publish","format-standard","hentry","category-education","category-fake"],"_links":{"self":[{"href":"https:\/\/nbsigh2.com\/index.php?rest_route=\/wp\/v2\/posts\/9124","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nbsigh2.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nbsigh2.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nbsigh2.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nbsigh2.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=9124"}],"version-history":[{"count":1,"href":"https:\/\/nbsigh2.com\/index.php?rest_route=\/wp\/v2\/posts\/9124\/revisions"}],"predecessor-version":[{"id":21534,"href":"https:\/\/nbsigh2.com\/index.php?rest_route=\/wp\/v2\/posts\/9124\/revisions\/21534"}],"wp:attachment":[{"href":"https:\/\/nbsigh2.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=9124"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nbsigh2.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=9124"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nbsigh2.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=9124"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}