{"id":28949,"date":"2026-11-11T06:33:10","date_gmt":"2026-11-10T21:33:10","guid":{"rendered":"https:\/\/nbsigh2.com\/?p=28949"},"modified":"2026-11-11T06:34:07","modified_gmt":"2026-11-10T21:34:07","slug":"%e8%89%b2%e7%9c%bc%e9%8f%a1%e3%81%a7%e8%ab%96%e6%96%87%e3%82%92%e8%aa%ad%e3%82%80%e3%81%a8","status":"publish","type":"post","link":"https:\/\/nbsigh2.com\/?p=28949","title":{"rendered":"\u8272\u773c\u93e1\u3067\u8ad6\u6587\u3092\u8aad\u3080\u3068"},"content":{"rendered":"<p>\u5b66\u3068\u307f\u5b50\u304c\uff11\uff11\u6708\uff16\u65e5\u5348\u524d\u4ee5\u6765\u3001\u6c88\u9ed9\u3057\u3066\u3044\u305f\u306e\u3067\u3059\u304c\uff11\uff10\u65e5\u591c\u3001\u6570\u3005\u306e\u8cea\u554f\u3001\u6279\u5224\u3092\u7121\u8996\u3057\u3066<a href=\"https:\/\/katura1.blog.fc2.com\/blog-entry-3254.html\" rel=\"noopener noreferrer\" target=\"_blank\">\u65b0\u3057\u3044\u8a18\u4e8b<\/a>\u3092\u30a2\u30c3\u30d7\u3057\u307e\u3057\u305f\u3002ES\u7d30\u80de\u304c\u3059\u3050\u5206\u5316\u3057\u3066\u30ad\u30e1\u30e9\u80fd\u3092\u5931\u3046\u304b\u3089\u5c0f\u4fdd\u65b9\u6c0f\u306e\u9178\u6d74\u3057\u305f\u7d30\u80de\u57f9\u990a\u4e2d\u306bES\u7d30\u80de\u304c\u6df7\u5165\u3057\u3066\u3082\u30ad\u30e1\u30e9\u306b\u306a\u3089\u306a\u3044\u3068\u3044\u3046\u304b\u306d\u3066\u304b\u3089\u306e\u4e3b\u5f35\u3092\u7e70\u308a\u8fd4\u3059\u8a18\u4e8b\u3067\u3059\u3002<\/p>\n<p>\u5192\u982d\u306e<span style=\"color: #0000ff;\">\u300c\u3053\u306e\u5185\u90e8\u7d30\u80de\u584a\u3092<u>\u4eba\u5de5\u7684\u306b\u6539\u5909\u3055\u305b\u3066\u5e79\u7d30\u80de\u5316\u3055\u305b\u305f<\/u>\u306e\u304cES\u7d30\u80de\u3067\u3059\u3002\u300d<\/span>\u3068\u3044\u3046\u6587\u7ae0\u304b\u3089\u3057\u3066\u3001\u8aa4\u308a\u3067\u3059\u3002\u5185\u90e8\u7d30\u80de\u584a\u306e\u7d30\u80de\u306f\u3082\u3068\u3082\u3068\u672a\u5206\u5316\u3067\u591a\u80fd\u6027\u3068\u5206\u88c2\u5897\u6b96\u80fd\u529b\u306e\u3042\u308b\u7d30\u80de\u3067\u3001\u80da\u5916\u306b\u53d6\u308a\u51fa\u3057\u3066\u3053\u306e\u672a\u5206\u5316\u72b6\u614b\u3092\u4eba\u5de5\u7684\u306b\u7dad\u6301\u3057\u3066\u3044\u308b\u7d30\u80de\u3092ES\u7d30\u80de\uff08\u80da\u6027\u5e79\u7d30\u80de\u3000embryonic stem cells\uff09\u3068\u3044\u3046\u306e\u3067\u3059\uff08\uff0a\uff11\uff09\u3002<span style=\"color: #0000ff;\">\u300c\u5e79\u7d30\u80de\u5316\u3055\u305b\u305f\u300d<\/span>\u306e\u3067\u306f\u306a\u304f\u3001\u5e79\u7d30\u80de\u3068\u3057\u3066\u306e\u6027\u8cea\u304c\u7dad\u6301\u3055\u308c\u305f\u7d30\u80de\u3067\u3059\u3002\u5b66\u3068\u307f\u5b50\u306f\u63da\u3052\u8db3\u53d6\u308a\u3068\u3044\u3046\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u304c\u3001\u4f55\u56de\u3082\u6307\u6458\u3057\u3066\u3044\u308b\u3088\u3046\u306b\u3001\u5b66\u3068\u307f\u5b50\u306f\u8a00\u8449\u306e\u5b9a\u7fa9\u3092\u7121\u8996\u3059\u308b\u3001\u5b58\u5728\u3057\u306a\u3044\u5c02\u9580\u7528\u8a9e\u98a8\u306e\u8a00\u8449\u3092\u4f5c\u308b\u7b49\u30c7\u30bf\u30e9\u30e1\u3092\u7e70\u308a\u8fd4\u3057\u3001\u6b63\u78ba\u3067\u306f\u306a\u3044\u8aac\u660e\u3092\u3057\u3066\u3082\u306a\u3093\u3068\u3082\u601d\u308f\u306a\u3044\u3001\u3055\u3089\u306b\u56fd\u5185\u6700\u9ad8\u306e\u6559\u80b2\u3092\u53d7\u3051\u535a\u58eb\u53f7\u3092\u6301\u3063\u3066\u3044\u308b\u306e\u306b\u65e5\u672c\u8a9e\u306b\u4e0d\u81ea\u7531\u306a\u308f\u3051\u3067\u3059\u3002<\/p>\n<p>\u3053\u3046\u3044\u3046\u30c7\u30bf\u30e9\u30e1\u6587\u7ae0\u304c\u5192\u982d\u306b\u3042\u308b\u3068\u3001\u305d\u308c\u3060\u3051\u3067\u8aad\u3080\u6c17\u304c\u5931\u305b\u308b\u30d6\u30ed\u30b0\u306a\u308f\u3051\u3067\u3059\u3002<\/p>\n<p><span style=\"color: #0000ff;\">\u300cAI\u306f\u3001\u4f8b\u3048\u8a71\u3067\u8aac\u660e\u3057\u3066\u3044\u307e\u3059\u3002\u300d<\/span>\u3068\u8a00\u3044\u307e\u3059\u304c\u3001AI\u306f\u3044\u304d\u306a\u308a\u4f8b\u3048\u8a71\u3092\u56de\u7b54\u3059\u308b\u3053\u3068\u306f\u306a\u304f\u3001\u5b66\u3068\u307f\u5b50\u306e\u30d7\u30ed\u30f3\u30d7\u30c8\u306e\u5165\u529b\u306b\u4f55\u7b49\u304b\u306e\u8981\u6c42\u304c\u3042\u3063\u305f\u304b\u3089\u3067\u3059\u3002\u8cea\u554f\u6587\u304c\u3044\u3064\u3082\u306e\u3088\u3046\u306b\u516c\u958b\u3055\u308c\u3066\u307e\u305b\u3093\u3001\u3057\u305f\u304c\u3063\u3066\u9752\u5b57\u3067\u8ee2\u8f09\u3055\u308c\u305f\u3089\u3057\u3044AI\u306e\u56de\u7b54\u306f\u3001\u5b66\u3068\u307f\u5b50\u306e\u610f\u56f3\u306b\u6cbf\u3063\u305f\u8fce\u5408\u306e\u7d50\u679c\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u306e\u3067\u3059\u3002<\/p>\n<p>\u5b66\u3068\u307f\u5b50\u306f<a href=\"https:\/\/www.cell.com\/cell-stem-cell\/fulltext\/S1934-5909(16)30193-X?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS193459091630193X%3Fshowall%3Dtrue\" rel=\"noopener noreferrer\" target=\"_blank\">Przybyla\u3000et al. Tissue Mechanics Orchestrate Wnt-Dependent Human Embryonic Stem Cell Differentiation  Cell Stem Cell. 2016 Jul 21;19(4):462\u2013475. <\/a>\uff08https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5336327\/\uff09\u3092\u5f15\u7528\u3057\u3066\u3001ES\u7d30\u80de\u306f\u74b0\u5883\u306e\u5909\u5316\u306b\u654f\u611f\u3067\u3001\u300c\u9178\u6d74\u7d30\u80de\u3068\u63a5\u89e6\u3059\u308b\u3068\u3059\u3050\u306b\u30ad\u30e1\u30e9\u80fd\u3092\u5931\u3046\u300d\u3068\u3044\u3046\u4e3b\u5f35\u3092\u88cf\u4ed8\u3051\u308b\u3053\u3068\u3092\u8a66\u307f\u305f\u306e\u304c\u3053\u306e\u8a18\u4e8b\u3067\u3059\u3002\u9752\u5b57\u306e\u4f8b\u3048\u8a71\u306f\u304a\u7b11\u3044\u306b\u3082\u306a\u3089\u306a\u3044\u30b4\u30df\u3067\u3059\u3002<\/p>\n<p>\u5b66\u3068\u307f\u5b50\u306f\u7d20\u4eba\u3067\u3082AI\u306e\u304a\u304b\u3052\u3066\u8ad6\u6587\u3092\u8aad\u3081\u308b\u3088\u3046\u306b\u306a\u3063\u305f\u3002\u3060\u304b\u3089\u5c02\u9580\u5bb6\u3067\u306a\u304f\u3066\u3082\u3001\u8ab0\u3067\u3082\u8ad6\u6587\u3084\u79d1\u5b66\u7684\u306a\u5831\u544a\u66f8\u3092\u7406\u89e3\u3067\u304d\u308b\u3068\u3044\u3063\u3066\u3044\u307e\u3059\u3002<br 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5 \u65e5\u5f8c\u3001\u81ea\u5df1\u66f4\u65b0\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308b Nanog \u304a\u3088\u3073 Oct4 \u306e mRNA \u30ec\u30d9\u30eb\uff08\u56f3 1C \u304a\u3088\u3073 S1C\uff09\u3084 Oct4 \u30bf\u30f3\u30d1\u30af\u8cea\uff08\u56f3 1D\uff09\u306a\u3069\u3001\u591a\u80fd\u6027\u306e\u5927\u307e\u304b\u306a\u6307\u6a19\u306b\u306f\u5909\u5316\u304c\u898b\u3089\u308c\u306a\u304b\u3063\u305f\u3002\u3055\u3089\u306b\u3001\u67d4\u3089\u304b\u3044\u57fa\u8cea\u307e\u305f\u306f\u786c\u3044\u57fa\u8cea\u304b\u3089\u7dda\u7dad\u82bd\u7d30\u80de\u30d5\u30a3\u30fc\u30c0\u30fc\u7d30\u80de\u4e0a\u306b\u518d\u64ad\u7a2e\u3055\u308c\u305f hESC \u306f\u3001\u4ed8\u7740\u30fb\u4f38\u5c55\u3057\u3001\u8907\u6570\u306e\u7d99\u4ee3\u306b\u308f\u305f\u3063\u3066\u591a\u80fd\u6027\u304a\u3088\u3073\u751f\u5b58\u6027\u3092\u7dad\u6301\u3057\u305f\u300d\u3068\u3044\u3046\u308f\u3051\u3067\u3059\u304b\u3089\u3001\u5b66\u3068\u307f\u5b50\u306eES\u7d30\u80de\u306f\u3059\u3050\u306b\u3067\u3082\u30ad\u30e1\u30e9\u80fd\uff08\u591a\u80fd\u6027\uff09\u3092\u5931\u3046\u3068\u3044\u3046\u4e3b\u5f35\u3068\u306f\u5168\u304f\u9006\u306e\u7d50\u679c\u3060\u3063\u305f\u308f\u3051\u3067\u3059\u3002\u3059\u3050\u306b\u5f62\u304c\u5909\u308f\u308b\u3051\u3069\u591a\u80fd\u6027\u3092\u5931\u3063\u305f\u308f\u3051\u3067\u306f\u306a\u3044\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u306d\u3002<\/p>\n<p>\u306f\u3044\u7d20\u4eba\u3067\u3082AI\u3092\u4f7f\u3046\u3068\u8ad6\u6587\u3092\u8aad\u307f\u3053\u308c\u3092\u5f15\u7528\u3057\u305f\u8a18\u4e8b\u3092\u8a55\u4fa1\u3067\u304d\u308b\u306e\u3067\u3059\u306d\u3002\u305d\u306e\u7d50\u679c\u3001\u8272\u773c\u93e1\u3067\u8ad6\u6587\u3092\u8aad\u307f\u3001\u8aa4\u3063\u305f\u3001\u81ea\u5206\u306b\u597d\u90fd\u5408\u306b\u89e3\u91c8\u3059\u308b\u5b66\u3068\u307f\u5b50\u304c\u8ab0\u306b\u3067\u3082\u308f\u304b\u308b\u3088\u3046\u306b\u306a\u3063\u305f\u308f\u3051\u3067\u3059\u3002\u304a\u30db\u30db\u3002<\/p>\n<p>\uff0a\uff11<\/p>\n<blockquote><p>Q\uff1a\u3000A\u3055\u3093\u304c\u300c\u5185\u90e8\u7d30\u80de\u584a\u3092\u4eba\u5de5\u7684\u306b\u6539\u5909\u3055\u305b\u3066\u5e79\u7d30\u80de\u5316\u3055\u305b\u305f\u306e\u304cES\u7d30\u80de\u3067\u3059\u3002\u300d\u3068\u305d\u306e\u30d6\u30ed\u30b0\u3067\u66f8\u304d\u307e\u3057\u305f\u304c\u3001\u3053\u308c\u3092\u8aad\u3093\u3060B\u3055\u3093\u306f\u300c\u9593\u9055\u3044\u3067\u3042\u308b\u3002\u5185\u90e8\u7d30\u80de\u584a\u306e\u7d30\u80de\u306f\u3082\u3068\u3082\u3068\u5e79\u7d30\u80de\uff08\u666e\u901a\u306f\u3053\u306e\u69d8\u306b\u547c\u3070\u306a\u3044\u304c\u3001\u672a\u5206\u5316\u3067\u69d8\u3005\u306a\u7d30\u80de\u306b\u5206\u5316\u3067\u304d\u308b\u7d30\u80de\u3068\u3044\u3046\u610f\u5473\uff09\u3060\u304b\u3089\u4eba\u5de5\u7684\u306b\u5e79\u7d30\u80de\u5316\u637a\u305b\u3089\u308c\u305f\u7d30\u80de\u3067\u306f\u306a\u3044\u3002\u4eba\u5de5\u7684\u306b\u591a\u80fd\u6027\u304c\u7dad\u6301\u3055\u308c\u5206\u88c2\u5897\u6b96\u80fd\u3092\u3082\u3063\u305f\u72b6\u614b\u304c\u7dad\u6301\u3055\u308c\u305f\u7d30\u80de\u3067\u3042\u308b\u300d\u3068\u6307\u6458\u3057\u307e\u3057\u305f\u3002A\u3055\u3093\u306e\u8aac\u660e\u3068B\u3055\u3093\u306e\u6307\u6458\u3069\u3061\u3089\u304c\u59a5\u5f53\u3067\u3057\u3087\u3046\u304b\u3002\u7c21\u6f54\u306b\u7b54\u3048\u3066\u3002<\/p>\n<p>ChatGPT\uff1a\u3000<strong>B\u3055\u3093\uff08\u305f\u3081\u606f\uff09\u306e\u6307\u6458\u306e\u65b9\u304c\u79d1\u5b66\u7684\u306b\u59a5\u5f53\u3067\u3059\u3002<\/strong><\/p>\n<p>\u5185\u90e8\u7d30\u80de\u584a\uff08ICM\uff09\u306e\u7d30\u80de\u306f\u3001\u3082\u3068\u3082\u3068\u591a\u80fd\u6027\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002ES\u7d30\u80de\u306f\u3001\u3053\u306e\u7d30\u80de\u3092\u57f9\u990a\u3057\u3001\u591a\u80fd\u6027\u3068\u81ea\u5df1\u8907\u88fd\u80fd\u3092\u9577\u671f\u306b\u308f\u305f\u3063\u3066\u7dad\u6301\u3067\u304d\u308b\u3088\u3046\u306b\u6a39\u7acb\u3057\u305f\u7d30\u80de\u3067\u3059\u3002<br \/>\n\u3000\u3057\u305f\u304c\u3063\u3066\u3001A\u3055\u3093\uff08\u5b66\u3068\u307f\u5b50\uff09\u306e\u300c\u4eba\u5de5\u7684\u306b\u6539\u5909\u3055\u305b\u3066\u5e79\u7d30\u80de\u5316\u3055\u305b\u305f\u300d\u3068\u3044\u3046\u8aac\u660e\u306f\u3001\u3082\u3068\u3082\u3068\u591a\u80fd\u6027\u306e\u3042\u308b\u7d30\u80de\u306b\u4eba\u5de5\u7684\u306b\u591a\u80fd\u6027\u3092\u4ed8\u4e0e\u3057\u305f\u304b\u306e\u3088\u3046\u306a\u8aa4\u89e3\u3092\u62db\u304d\u3001\u4e0d\u6b63\u78ba\u3067\u3059\u3002<br \/>\n\u3000\u305f\u3060\u3057\u3001ICM\u306e\u7d30\u80de\u3068\u6a39\u7acb\u3055\u308c\u305fES\u7d30\u80de\u306f\u540c\u4e00\u3067\u306f\u306a\u304f\u3001\u57f9\u990a\u306b\u3088\u3063\u3066\u5b89\u5b9a\u3057\u305f\u81ea\u5df1\u8907\u88fd\u80fd\u3092\u7372\u5f97\u30fb\u7dad\u6301\u3059\u308b\u70b9\u306b\u306f\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002\n<\/p><\/blockquote>\n<p>\uff0a\uff12<\/p>\n<blockquote><p>Q\uff1a\u3000\u4ee5\u4e0b\u306e\u300e\u3000\u300f\u5185\u306f\u5b66\u3068\u307f\u5b50\u3055\u3093\u306e\u30d6\u30ed\u30b0\u8a18\u4e8b\uff08https:\/\/katura1.blog.fc2.com\/blog-entry-3254.html\uff09\u3067\u3059\u3002\u5b66\u3068\u307f\u5b50\u3055\u3093\u306fSTAP\u7d30\u80de\u4e8b\u4ef6\u3067\u3001ES\u7d30\u80de\u306f\u5206\u5316\u3057\u305f\u7d30\u80de\u3068\u63a5\u89e6\u3059\u308b\u3068\u3059\u3050\u306b\u30ad\u30e1\u30e9\u80fd\u3092\u5931\u3046\u304b\u3089\u3001ES\u7d30\u80de\u306e\u6df7\u5165\u306f\u5c0f\u4fdd\u65b9\u6c0f\u304c\u9178\u306b\u66b4\u9732\u3057\u305f\u7d30\u80de\u3092\u57f9\u990a\u3057\u3066\u3044\u308b\uff17\u65e5\u9593\u3067\u751f\u3058\u305f\u306e\u3067\u306f\u306a\u3044\u3068\u4e3b\u5f35\u3057\u3066\u304a\u308a\u3001\u305d\u306e\u6839\u62e0\u3068\u3057\u3066\u3053\u306e\u8a18\u4e8b\u3092\u66f8\u3044\u3066\u3044\u307e\u3059\u3002\u5f15\u7528\u3055\u308c\u3066\u3044\u308b\u8ad6\u6587\u306epdf\u3092\u6dfb\u4ed8\u3057\u307e\u3057\u305f\u3002<br \/>\n\u5b66\u3068\u307f\u5b50\u3055\u3093\u306e\u4e3b\u5f35\u3068\u3053\u306e\u30d6\u30ed\u30b0\u8a18\u4e8b\u3092\u8a55\u4fa1\u3057\u3066\u304f\u3060\u3055\u3044\u3002<br \/>\n\u300e\u8003\u5bdf\u5b66\u3068\u307f\u5b50<br \/>\n\u4e0b\u5730\u30b2\u30eb\u306e\u786c\u3055\u3092\u5909\u3048\u305f\u3060\u3051\u300d\u3068\u3044\u3046\u3001\u4e00\u898b\u30de\u30a4\u30eb\u30c9\u306a\u4eba\u5de5\u7684\u5909\u5316\u3067\u3055\u3048\u3001\u30d2\u30c8ES\u7d30\u80de\u306f\u63a5\u7740\u3092\u5d29\u58ca\u3055\u305b\u3001\u5206\u5316\u30b7\u30b0\u30ca\u30eb\uff08\u03b2-\u30ab\u30c6\u30cb\u30f3\uff09\u3092\u6fc0\u5909\u3055\u305b\u3066\u3057\u307e\u3044\u307e\u3059\u3002<br \/>\n2026\/11\/10<br \/>\nES\u306f\u3082\u3068\u3082\u3068\u3001\u67d4\u3089\u304b\u304f\u5909\u5316\u3057\u3084\u3059\u3044\u7d30\u80de\u3067\u3059\u3002<br \/>\n\u305d\u3046\u3057\u305fES\u306e\u8106\u5f31\u6027\u3092\u793a\u3057\u305f\u3001\u8208\u5473\u6df1\u3044\u8ad6\u6587\u3092\u898b\u3064\u3051\u307e\u3057\u305f\u3002<\/p>\n<p>\uff08\u7701\u7565\u3002\u5b66\u3068\u307f\u5b50\u306e\u8a18\u4e8b\uff08https:\/\/katura1.blog.fc2.com\/blog-entry-3254.html\uff09\u5168\u90e8\u306e\u30b3\u30d4\u30da\u3067\u3059\u3002\u9577\u304f\u306a\u308b\u306e\u3067\u3053\u3053\u3067\u306f\u7565\u3057\u307e\u3059\u3002\uff09<\/p>\n<p>\u4ee5\u4e0b\u306e\u56f3\u3092\u53c2\u8003\u306b\u3057\u3066\u304f\u3060\u3055\u3044\u3002\uff08\u56f3\u306e\u5f15\u7528\u5143\uff1aPrzybyla L, et al. Cell Stem Cell. 2016. Fig.1 \/ Graphical Abstract \u3088\u308a\u5f15\u7528\uff09<\/p>\n<p>\u56fa\u3044\u67d4\u3089\u304b\u3044\u4e0b\u5730\u306b\u304a\u3051\u308bES\u306e\u9055\u3044\u300f<\/p>\n<p>\u6dfb\u4ed8\uff1anihms852644.pdf\u3000https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5336327\/pdf\/nihms852644.pdf<\/p>\n<p>ChatGPT\uff1a\u3000## \u7dcf\u5408\u8a55\u4fa1<\/p>\n<p><strong>\u5b66\u3068\u307f\u5b50\u3055\u3093\u306e\u4e3b\u5f35\u306f\u3001\u5f15\u7528\u8ad6\u6587\u306e\u7814\u7a76\u7d50\u679c\u3092\u8aa4\u3063\u3066\u62e1\u5927\u89e3\u91c8\u3057\u305f\u3082\u306e\u3067\u3001\u79d1\u5b66\u7684\u6839\u62e0\u304c\u3042\u308a\u307e\u305b\u3093\u3002<\/strong><\/p>\n<p>\u7279\u306b\u91cd\u5927\u306a\u306e\u306f\u3001\u5f15\u7528\u8ad6\u6587\u304c\u793a\u3057\u3066\u3044\u308b\u7d50\u679c\u306e\u4e00\u90e8\u304c\u3001\u5b66\u3068\u307f\u5b50\u3055\u3093\u306e\u8aac\u660e\u3068\u306f\u6b63\u53cd\u5bfe\u3067\u3042\u308b\u3053\u3068\u3067\u3059\u3002<br \/>\n\u6dfb\u4ed8\u3055\u308c\u305fPrzybyla\u3089\uff082016\uff09\u306e\u8ad6\u6587\u3068\u30d6\u30ed\u30b0\u8a18\u4e8b\u3092\u6bd4\u8f03\u3059\u308b\u3068\u3001\u6b21\u306e\u3088\u3046\u306b\u8a55\u4fa1\u3067\u304d\u307e\u3059\u3002<\/p>\n<p>## 1. \u30d6\u30ed\u30b0\u8a18\u4e8b\u306e\u4e3b\u5f35\u3068\u8ad6\u6587\u306e\u6bd4\u8f03<\/p>\n<table style=\"border-collapse: collapse; width: 100%;\" border=\"1\" cellpadding=\"6\">\n<thead>\n<tr>\n<th>\u5b66\u3068\u307f\u5b50\u3055\u3093\u306e\u4e3b\u5f35<\/th>\n<th>\u8a55\u4fa1<\/th>\n<th>\u7406\u7531<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u2460 ES\u7d30\u80de\u306f\u74b0\u5883\u306e\u5909\u5316\u306b\u654f\u611f\u3067\u3042\u308b<\/td>\n<td>\u59a5\u5f53<\/td>\n<td>\u57fa\u8cea\u306e\u786c\u3055\u304c\u7d30\u80de\u63a5\u7740\u3084\u5206\u5316\u30b7\u30b0\u30ca\u30eb\u306b\u5f71\u97ff\u3059\u308b\u3053\u3068\u306f\u8ad6\u6587\u3067\u793a\u3055\u308c\u3066\u3044\u308b\u3002<\/td>\n<\/tr>\n<tr>\n<td>\u2461 \u786c\u3044\u30b2\u30eb\u3067\u306f\u03b2-\u30ab\u30c6\u30cb\u30f3\u304c\u5206\u89e3\u3055\u308c\u308b<\/td>\n<td>\u59a5\u5f53<\/td>\n<td>Fig.6\u306a\u3069\u3067\u5b9f\u8a3c\u3055\u308c\u3066\u3044\u308b\u3002\u305f\u3060\u3057\u3001\u3053\u308c\u306fES\u7d30\u80de\u306e\u591a\u80fd\u6027\u55aa\u5931\u3092\u610f\u5473\u3057\u306a\u3044\u3002<\/td>\n<\/tr>\n<tr>\n<td>\u2462 \u30b2\u30eb\u306e\u786c\u3055\u3092\u5909\u3048\u308b\u3060\u3051\u3067ES\u7d30\u80de\u304c\u52a3\u5316\u3059\u308b<\/td>\n<td>\u8aa4\u308a<\/td>\n<td>\u8ad6\u6587\u3067\u306f\u786c\u3044\u30b2\u30eb\u3067\u3082\u591a\u80fd\u6027\u3068\u81ea\u5df1\u8907\u88fd\u80fd\u304c\u7dad\u6301\u3055\u308c\u305f\u3002<\/td>\n<\/tr>\n<tr>\n<td>\u2463 \u4ed6\u306e\u7d30\u80de\u3068\u63a5\u89e6\u3059\u308b\u3068ES\u7d30\u80de\u306e\u63a5\u7740\u304c\u5d29\u58ca\u3059\u308b<\/td>\n<td>\u6839\u62e0\u306a\u3057<\/td>\n<td>\u7570\u7a2e\u7d30\u80de\u3068\u306e\u6df7\u5408\u30fb\u63a5\u89e6\u3092\u691c\u8a3c\u3057\u305f\u5b9f\u9a13\u3067\u306f\u306a\u3044\u3002<\/td>\n<\/tr>\n<tr>\n<td>\u2464 \u6570\u5206\u301c\u6570\u6642\u9593\u3067ES\u7d30\u80de\u304c\u4e0d\u53ef\u9006\u7684\u306b\u52a3\u5316\u3059\u308b<\/td>\n<td>\u6839\u62e0\u306a\u3057<\/td>\n<td>2\u6642\u9593\u4ee5\u5185\u306e\u30b7\u30b0\u30ca\u30eb\u5909\u5316\u306f\u793a\u3055\u308c\u305f\u304c\u3001\u4e0d\u53ef\u9006\u7684\u306a\u591a\u80fd\u6027\u55aa\u5931\u306f\u793a\u3055\u308c\u3066\u3044\u306a\u3044\u3002<\/td>\n<\/tr>\n<tr>\n<td>\u2465 \u5206\u5316\u7d30\u80de\u304c\u6df7\u5165\u3059\u308b\u3068ES\u7d30\u80de\u306f\u30ad\u30e1\u30e9\u80fd\u3092\u5931\u3046<\/td>\n<td>\u6839\u62e0\u306a\u3057<\/td>\n<td>\u30d2\u30c8ES\u7d30\u80de\u3092\u4f7f\u3063\u305f\u7814\u7a76\u3067\u3042\u308a\u3001\u30ad\u30e1\u30e9\u5f62\u6210\u80fd\u306f\u6e2c\u5b9a\u3057\u3066\u3044\u306a\u3044\u3002<\/td>\n<\/tr>\n<tr>\n<td>\u2466 \u9178\u51e6\u7406\u7d30\u80de\u3068\u306e\u6df7\u5408\u306f\u30b2\u30eb\u306e\u786c\u3055\u306e\u5909\u5316\u3088\u308a\u904e\u9177\u3067\u3042\u308b<\/td>\n<td>\u63a8\u6e2c<\/td>\n<td>DAMPs\u306a\u3069\u306b\u3088\u308b\u5f71\u97ff\u3092\u60f3\u5b9a\u3057\u3066\u3044\u308b\u304c\u3001\u3053\u306e\u8ad6\u6587\u3067\u306f\u5b9f\u9a13\u3057\u3066\u3044\u306a\u3044\u3002<\/td>\n<\/tr>\n<tr>\n<td>\u2467 ES\u7d30\u80de\u306e\u6df7\u5165\u306fSTAP\u7d30\u80de\u306e7\u65e5\u9593\u306e\u57f9\u990a\u4e2d\u306b\u306f\u8d77\u3053\u308a\u5f97\u306a\u3044<\/td>\n<td>\u7d50\u8ad6\u3092\u652f\u6301\u3067\u304d\u306a\u3044<\/td>\n<td>\u3053\u306e\u8ad6\u6587\u304b\u3089\u6df7\u5165\u6642\u671f\u3092\u63a8\u5b9a\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u306a\u3044\u3002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>## 2. \u6700\u3082\u91cd\u8981\u306a\u554f\u984c\uff1a\u8ad6\u6587\u306f\u591a\u80fd\u6027\u304c\u5931\u308f\u308c\u306a\u3044\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u308b<\/p>\n<p>\u8ad6\u6587\u306eResults\u30013\u301c4\u30da\u30fc\u30b8\u306b\u3001\u6b21\u306e\u898b\u51fa\u3057\u304c\u3042\u308a\u307e\u3059\u3002<br \/>\nSubstrate Compliance Does Not Affect hESC Self-Renewal<br \/>\n\u300c\u57fa\u8cea\u306e\u67d4\u3089\u304b\u3055\u306f\u30d2\u30c8ES\u7d30\u80de\u306e\u81ea\u5df1\u8907\u88fd\u80fd\u306b\u5f71\u97ff\u3057\u306a\u3044\u300d<br \/>\n\u3055\u3089\u306b4\u30da\u30fc\u30b8\u306b\u306f\u3001\u6b21\u306e\u8a18\u8ff0\u304c\u3042\u308a\u307e\u3059\u3002<br \/>\n> Importantly, 5 days after culture, gross measures of pluripotency, including mRNA levels of the self-renewal markers Nanog and Oct4 &#8230; remained unchanged.<br \/>\n\u3064\u307e\u308a\u30015\u65e5\u9593\u57f9\u990a\u3057\u3066\u3082\u3001Nanog\u3084Oct4\u306a\u3069\u306e\u591a\u80fd\u6027\u6307\u6a19\u306f\u5909\u5316\u3057\u306a\u304b\u3063\u305f\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<br \/>\n\u3055\u3089\u306b\u3001\u67d4\u3089\u304b\u3044\u30b2\u30eb\u3067\u3082\u786c\u3044\u30b2\u30eb\u3067\u3082\u3001\u57f9\u990a\u3057\u305fES\u7d30\u80de\u3092\u30d5\u30a3\u30fc\u30c0\u30fc\u7d30\u80de\u4e0a\u306b\u79fb\u3059\u3068\u3001\u8907\u6570\u56de\u306e\u7d99\u4ee3\u306b\u308f\u305f\u308a\u591a\u80fd\u6027\u3068\u751f\u5b58\u80fd\u529b\u304c\u7dad\u6301\u3055\u308c\u307e\u3057\u305f\u3002<br \/>\n\u8457\u8005\u3089\u306f\u660e\u78ba\u306b\u7d50\u8ad6\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n> These findings indicate that, despite a marked effect on cell morphology, ECM stiffness has little to no direct effect on hESC differentiation or pluripotency.<br \/>\n<strong>\u300c\u7d30\u80de\u5f62\u614b\u306b\u306f\u9855\u8457\u306a\u5f71\u97ff\u304c\u3042\u308b\u3082\u306e\u306e\u3001\u57fa\u8cea\u306e\u786c\u3055\u306f\u30d2\u30c8ES\u7d30\u80de\u306e\u5206\u5316\u3084\u591a\u80fd\u6027\u306b\u76f4\u63a5\u7684\u306b\u306f\u307b\u3068\u3093\u3069\u5f71\u97ff\u3057\u306a\u3044\u300d<\/strong><br \/>\n\u51fa\u5178\uff1a\u6dfb\u4ed8\u8ad6\u6587 Results, pp.3\u20134, Fig.1&#x20;<\/p>\n<p>nihms852644.pdf<\/p>\n<p>\u3053\u308c\u306f\u5b66\u3068\u307f\u5b50\u3055\u3093\u306e\u300c\u786c\u3055\u306e\u5909\u5316\u3060\u3051\u3067ES\u7d30\u80de\u304c\u4e0d\u53ef\u9006\u7684\u306b\u52a3\u5316\u3059\u308b\u300d\u3068\u3044\u3046\u4e3b\u5f35\u3068\u660e\u78ba\u306b\u77db\u76fe\u3057\u307e\u3059\u3002<\/p>\n<p>## 3. Fig.7\u306e\u300c2\u6642\u9593\u4ee5\u5185\u300d\u306e\u610f\u5473\u3092\u53d6\u308a\u9055\u3048\u3066\u3044\u308b<\/p>\n<p>\u5b66\u3068\u307f\u5b50\u3055\u3093\u306f\u3001Fig.7A\u306e2\u6642\u9593\u4ee5\u5185\u306eSFK\u6d3b\u6027\u5316\u3092\u6839\u62e0\u306b\u3001ES\u7d30\u80de\u304c\u77ed\u6642\u9593\u3067\u4e0d\u53ef\u9006\u7684\u306b\u52a3\u5316\u3059\u308b\u3068\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002<br \/>\n\u3057\u304b\u3057\u3001\u8ad6\u6587\u306e\u5b9f\u9a13\u306f\u6b21\u306e\u3088\u3046\u306a\u3082\u306e\u3067\u3059\u3002<br \/>\n&#8211; \u67d4\u3089\u304b\u3044\u30b2\u30eb\u4e0a\u306e\u30d2\u30c8ES\u7d30\u80de\u306b\u5206\u5316\u8a98\u5c0e\u56e0\u5b50\u3092\u52a0\u3048\u308b\u3002<br \/>\n&#8211; 2\u6642\u9593\u4ee5\u5185\u306bSFK\u306e\u30ea\u30f3\u9178\u5316\u304c\u8d77\u3053\u308b\u3002<br \/>\n&#8211; E-\u30ab\u30c9\u30d8\u30ea\u30f3\u3092\u542b\u3080\u7d30\u80de\u9593\u63a5\u7740\u69cb\u9020\u304c\u518d\u7de8\u6210\u3055\u308c\u308b\u3002<br \/>\n&#8211; \u03b2-\u30ab\u30c6\u30cb\u30f3\u306e\u8ee2\u5199\u6d3b\u6027\u304c\u9ad8\u307e\u308a\u3001\u4e2d\u80da\u8449\u3078\u306e\u5206\u5316\u304c\u4fc3\u9032\u3055\u308c\u308b\u3002<br \/>\n\u3064\u307e\u308a\u3001\u6b63\u5e38\u306a\u5206\u5316\u8a98\u5c0e\u904e\u7a0b\u306b\u4f34\u3046\u30b7\u30b0\u30ca\u30eb\u5909\u5316\u3092\u89b3\u5bdf\u3057\u305f\u5b9f\u9a13\u3067\u3059\u3002<br \/>\nES\u7d30\u80de\u304c\u7570\u7a2e\u7d30\u80de\u3068\u306e\u63a5\u89e6\u306b\u3088\u3063\u3066\u640d\u50b7\u3057\u305f\u5b9f\u9a13\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<br \/>\n\u3080\u3057\u308d\u3001\u5b66\u3068\u307f\u5b50\u3055\u3093\u306f\u300c\u6b63\u5e38\u306a\u5206\u5316\u8a98\u5c0e\u300d\u3092\u300c\u4e0d\u53ef\u9006\u7684\u306a\u7d30\u80de\u306e\u52a3\u5316\u300d\u3068\u8aad\u307f\u66ff\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>nihms852644.pdf<\/p>\n<p>## 4. \u30d2\u30c8ES\u7d30\u80de\u3068\u30de\u30a6\u30b9ES\u7d30\u80de\u306e\u9055\u3044\u3092\u7121\u8996\u3057\u3066\u3044\u308b<\/p>\n<p>\u3053\u306e\u8ad6\u6587\u3067\u4f7f\u7528\u3055\u308c\u305f\u306e\u306f\u3001\u30d2\u30c8ES\u7d30\u80de\uff08H9\u3001H7\uff09\u3067\u3059\u3002<br \/>\n\u4e00\u65b9\u3001STAP\u7d30\u80de\u4e8b\u4ef6\u3067\u554f\u984c\u3068\u306a\u3063\u305f\u306e\u306f\u30de\u30a6\u30b9ES\u7d30\u80de\u3067\u3059\u3002<br \/>\n\u4e21\u8005\u306b\u306f\u672a\u5206\u5316\u72b6\u614b\u3084\u57f9\u990a\u6761\u4ef6\u306a\u3069\u306b\u91cd\u8981\u306a\u9055\u3044\u304c\u3042\u308a\u307e\u3059\u3002<br \/>\n\u3055\u3089\u306b\u3001\u3053\u306e\u8ad6\u6587\u3067\u306f\u30de\u30a6\u30b9\u306e\u80da\u76e4\u80de\u3078\u306e\u6ce8\u5165\u5b9f\u9a13\u3082\u30ad\u30e1\u30e9\u5f62\u6210\u80fd\u306e\u6e2c\u5b9a\u3082\u5b9f\u65bd\u3057\u3066\u3044\u307e\u305b\u3093\u3002<br \/>\n\u3057\u305f\u304c\u3063\u3066\u3001\u30d2\u30c8ES\u7d30\u80de\u306e\u4e2d\u80da\u8449\u5206\u5316\u306b\u95a2\u3059\u308b\u7d50\u679c\u304b\u3089\u3001\u30de\u30a6\u30b9ES\u7d30\u80de\u306e\u30ad\u30e1\u30e9\u5f62\u6210\u80fd\u304c\u77ed\u6642\u9593\u3067\u5931\u308f\u308c\u308b\u3068\u7d50\u8ad6\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n<p>## 5. \u300c\u6df7\u5165\u3057\u305f\u3089\u30ad\u30e1\u30e9\u80fd\u3092\u5931\u3046\u300d\u3068\u3044\u3046\u4e3b\u5f35\u306e\u554f\u984c<\/p>\n<p>\u5b66\u3068\u307f\u5b50\u3055\u3093\u306e\u8b70\u8ad6\u306b\u306f\u3001\u6b21\u306e\u8ad6\u7406\u7684\u98db\u8e8d\u304c\u3042\u308a\u307e\u3059\u3002<br \/>\n\u8ad6\u6587\u3067\u5b9f\u8a3c\u3055\u308c\u305f\u4e8b\u5b9f<br \/>\n\u57fa\u8cea\u306e\u786c\u3055\u304c\u30d2\u30c8ES\u7d30\u80de\u306e\u63a5\u7740\u72b6\u614b\u3084\u5206\u5316\u5fdc\u7b54\u306b\u5f71\u97ff\u3059\u308b<br \/>\n\u8ad6\u6587\u3067\u306f\u5b9f\u8a3c\u3055\u308c\u3066\u3044\u306a\u3044\u63a8\u6e2c<br \/>\n\u5206\u5316\u7d30\u80de\u3068\u306e\u63a5\u89e6\u3067ES\u7d30\u80de\u304c\u6025\u901f\u306b\u52a3\u5316\u3059\u308b<br \/>\n\u3055\u3089\u306b<strong>\u6839\u62e0\u306e\u306a\u3044\u7d50\u8ad6\uff1a\u6570\u5206\u301c\u6570\u6642\u9593\u3067\u30de\u30a6\u30b9ES\u7d30\u80de\u306e\u30ad\u30e1\u30e9\u5f62\u6210\u80fd\u304c\u4e0d\u53ef\u9006\u7684\u306b\u5931\u308f\u308c\u308b<\/strong><br \/>\n\u305d\u3082\u305d\u3082<strong>ES\u7d30\u80de\u306f\u3001\u901a\u5e38\u306e\u57f9\u990a\u3067\u3082\u30d5\u30a3\u30fc\u30c0\u30fc\u7d30\u80de\u306a\u3069\u306e\u7570\u306a\u308b\u7a2e\u985e\u306e\u7d30\u80de\u3068\u5171\u5b58\u3067\u304d\u307e\u3059\u3002<\/strong>\u3057\u305f\u304c\u3063\u3066\u3001<strong>\u7570\u7a2e\u7d30\u80de\u3068\u306e\u63a5\u89e6\u305d\u306e\u3082\u306e\u304c\u5fc5\u305aES\u7d30\u80de\u3092\u52a3\u5316\u3055\u305b\u308b\u3068\u3044\u3046\u8003\u3048\u65b9\u306f\u6210\u7acb\u3057\u307e\u305b\u3093\u3002<\/strong><br \/>\n\u3082\u3061\u308d\u3093\u3001\u9178\u51e6\u7406\u5f8c\u306e\u7d30\u80de\u96c6\u56e3\u304cES\u7d30\u80de\u306b\u60aa\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u306f\u5426\u5b9a\u3067\u304d\u307e\u305b\u3093\u3002\u3057\u304b\u3057\u3001\u305d\u306e\u7a0b\u5ea6\u3084\u6642\u9593\u7d4c\u904e\u3001\u30ad\u30e1\u30e9\u5f62\u6210\u80fd\u3078\u306e\u5f71\u97ff\u306f\u3001\u5b9f\u969b\u306b\u691c\u8a3c\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>## \u7d50\u8ad6<\/p>\n<p>\u4eca\u56de\u306e\u30d6\u30ed\u30b0\u8a18\u4e8b\u306b\u306f\u3001\u7279\u306b\u91cd\u5927\u306a\u554f\u984c\u304c3\u3064\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>1. \u8ad6\u6587\u306e\u7d50\u679c\u3068\u77db\u76fe\u3059\u308b\u8aac\u660e\u3092\u3057\u3066\u3044\u308b\u3002 \u8ad6\u6587\u306f\u57fa\u8cea\u306e\u786c\u3055\u306b\u3088\u3063\u3066ES\u7d30\u80de\u306e\u591a\u80fd\u6027\u304c\u76f4\u63a5\u5931\u308f\u308c\u308b\u308f\u3051\u3067\u306f\u306a\u3044\u3068\u793a\u3057\u3066\u3044\u308b\u3002<br \/>\n2. \u6b63\u5e38\u306a\u5206\u5316\u30b7\u30b0\u30ca\u30eb\u306e\u6d3b\u6027\u5316\u3092\u3001\u4e0d\u53ef\u9006\u7684\u306a\u7d30\u80de\u306e\u52a3\u5316\u3068\u6df7\u540c\u3057\u3066\u3044\u308b\u3002<br \/>\n3. \u30d2\u30c8ES\u7d30\u80de\u306e\u5206\u5316\u7814\u7a76\u304b\u3089\u3001\u30de\u30a6\u30b9ES\u7d30\u80de\u306e\u30ad\u30e1\u30e9\u5f62\u6210\u80fd\u55aa\u5931\u3068STAP\u7d30\u80de\u3078\u306e\u6df7\u5165\u6642\u671f\u3092\u8ad6\u3058\u3066\u3044\u308b\u3002<\/p>\n<p>\u3057\u305f\u304c\u3063\u3066\u3001\u3053\u306e\u8ad6\u6587\u306f\u300cES\u7d30\u80de\u304c\u9178\u51e6\u7406\u7d30\u80de\u3068\u63a5\u89e6\u3059\u308b\u3068\u77ed\u6642\u9593\u3067\u30ad\u30e1\u30e9\u80fd\u3092\u5931\u3046\u300d\u3068\u3044\u3046\u5b66\u3068\u307f\u5b50\u3055\u3093\u306e\u4e3b\u5f35\u306e\u6839\u62e0\u306b\u306f\u306a\u308a\u307e\u305b\u3093\u3002<\/p>\n<p>\u305f\u3060\u3057\u3001\u3053\u306e\u8a55\u4fa1\u306f7\u65e5\u9593\u306e\u57f9\u990a\u4e2d\u306bES\u7d30\u80de\u304c\u5b9f\u969b\u306b\u6df7\u5165\u3057\u305f\u3053\u3068\u3092\u8a3c\u660e\u3059\u308b\u3082\u306e\u3067\u3082\u3042\u308a\u307e\u305b\u3093\u3002\u6df7\u5165\u306e\u53ef\u80fd\u6027\u3068\u3001\u5b9f\u969b\u306b\u3044\u3064\u6df7\u5165\u3057\u305f\u304b\u3068\u3044\u3046\u554f\u984c\u306f\u533a\u5225\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>\u7279\u306b\u6ce8\u76ee\u3059\u3079\u304d\u306a\u306e\u306f\u3001\u5b66\u3068\u307f\u5b50\u3055\u3093\u304c\u8ad6\u6587\u306eFig.7\u306e2\u6642\u9593\u3068\u3044\u3046\u7d50\u679c\u3092\u7e70\u308a\u8fd4\u3057\u5f37\u8abf\u3057\u306a\u304c\u3089\u3001Fig.1\u3067\u793a\u3055\u308c\u305f\u591a\u80fd\u6027\u7dad\u6301\u3068\u3044\u3046\u3001\u672c\u4eba\u306e\u4e3b\u5f35\u306b\u4e0d\u90fd\u5408\u306a\u5b9f\u9a13\u7d50\u679c\u3092\u53d6\u308a\u4e0a\u3052\u3066\u3044\u306a\u3044\u3053\u3068\u3067\u3059\u3002\u8ad6\u6587\u5168\u4f53\u306e\u8a55\u4fa1\u3068\u3057\u3066\u3001\u3053\u308c\u306f\u91cd\u5927\u306a\u6b20\u843d\u3067\u3059\u3002\n<\/p><\/blockquote>\n","protected":false},"excerpt":{"rendered":"<p>\u5b66\u3068\u307f\u5b50\u304c\uff11\uff11\u6708\uff16\u65e5\u5348\u524d\u4ee5\u6765\u3001\u6c88\u9ed9\u3057\u3066\u3044\u305f\u306e\u3067\u3059\u304c\uff11\uff10\u65e5\u591c\u3001\u6570\u3005\u306e\u8cea\u554f\u3001\u6279\u5224\u3092\u7121\u8996\u3057\u3066\u65b0\u3057\u3044\u8a18\u4e8b\u3092\u30a2\u30c3\u30d7\u3057\u307e\u3057\u305f\u3002ES\u7d30\u80de\u304c\u3059\u3050\u5206\u5316\u3057\u3066\u30ad\u30e1\u30e9\u80fd\u3092\u5931\u3046\u304b\u3089\u5c0f\u4fdd\u65b9\u6c0f\u306e\u9178\u6d74\u3057\u305f\u7d30\u80de\u57f9\u990a\u4e2d\u306bES\u7d30\u80de\u304c\u6df7\u5165\u3057\u3066\u3082\u30ad\u30e1\u30e9\u306b\u306a\u3089\u306a\u3044 &hellip; <a href=\"https:\/\/nbsigh2.com\/?p=28949\" class=\"more-link\">\u7d9a\u304d\u3092\u8aad\u3080 <span class=\"screen-reader-text\">\u8272\u773c\u93e1\u3067\u8ad6\u6587\u3092\u8aad\u3080\u3068<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2,8],"tags":[],"class_list":["post-28949","post","type-post","status-publish","format-standard","hentry","category-education","category-fake"],"_links":{"self":[{"href":"https:\/\/nbsigh2.com\/index.php?rest_route=\/wp\/v2\/posts\/28949","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nbsigh2.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nbsigh2.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nbsigh2.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nbsigh2.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=28949"}],"version-history":[{"count":5,"href":"https:\/\/nbsigh2.com\/index.php?rest_route=\/wp\/v2\/posts\/28949\/revisions"}],"predecessor-version":[{"id":28954,"href":"https:\/\/nbsigh2.com\/index.php?rest_route=\/wp\/v2\/posts\/28949\/revisions\/28954"}],"wp:attachment":[{"href":"https:\/\/nbsigh2.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=28949"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nbsigh2.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=28949"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nbsigh2.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=28949"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}