{"id":28661,"date":"2026-09-26T02:46:05","date_gmt":"2026-09-25T17:46:05","guid":{"rendered":"https:\/\/nbsigh2.com\/?p=28661"},"modified":"2026-09-26T02:46:16","modified_gmt":"2026-09-25T17:46:16","slug":"gfp%e5%85%a5%e3%82%8aes%e3%81%a8ts%e3%82%92%e4%b8%a1%e6%96%b9%e5%85%a5%e3%82%8c%e3%82%8b","status":"publish","type":"post","link":"https:\/\/nbsigh2.com\/?p=28661","title":{"rendered":"GFP\u5165\u308aES\u3068TS\u3092\u4e21\u65b9\u5165\u308c\u308b"},"content":{"rendered":"

\u5b66\u3068\u307f\u5b50\u66f0\u304f\uff1a\u300c\u4e00\u822c\u4eba\u306f\u3001GFP\u5165\u308aES\u3068TS\u3092\u4e21\u65b9\u3044\u308c\u308c\u3070\u3001\u80ce\u5150\u3082\u80ce\u76e4\u3092\u5149\u3089\u305b\u308b\u4e8b\u304c\u3067\u304d\u308b\u3068\u6559\u308f\u3063\u305f\u306e\u3088\u3002\u305f\u3081\u606f\u3055\u3093\u3082\u305d\u3046\u8003\u3048\u305f\u3093\u3067\u3057\u3087\u3046\uff1f\u300d<\/span><\/a>\u3000\u2190\u3000\u306a\u3093\u3067\u3059\u304b\u306d\uff1f\u3053\u306e\u767a\u8a00\u306f\uff1f<\/p>\n

\u660e\u3089\u304b\u306b\u3053\u306e\u6587\u7ae0\u306f\u300cGFP\u5165\u308a\uff08CAG-GFP\uff09ES\u3068TS\u3092\u4e21\u65b9\u3092\u80de\u80da\u671f\u306e\u80da\u306b\u6ce8\u5165\u3059\u308c\u3070\u3001\u80ce\u5150\u3082\u80ce\u76e4\u306bGFP\u3092\u767a\u73fe\u3057\u305f\u7d30\u80de\u3092\u542b\u3080\u30ad\u30e1\u30e9\u304c\u3067\u304d\u308b\u300d\u3068\u3044\u3046\u610f\u5473\u3067\u3059\u3002\u3057\u304b\u3057Letter\u3067\u793a\u3057\u3066\u3044\u308b\u7d50\u679c\u306eFig.2\u306fCAG-GFP\u306eFI-SC\uff08Fgf4-induced stem cells\uff09\u3092\u80de\u80da\u671f\u306b\u6ce8\u5165\u3057\u305f\u3089\u80ce\u76e4\u3068\u80ce\u5150\u306b\u767a\u73fe\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u7d50\u679c\u3067\u3059\u3002\u5b66\u3068\u307f\u5b50\u3055\u3093\u306e\u4e3b\u5f35\u3059\u308b\u300cGFP\u5165\u308aES\u3068TS\u3092\u4e21\u65b9\u3044\u308c\u305f\u300d\u3068\u3044\u3046\u5b9f\u9a13\u306fLetter\u306b\u3042\u308a\u307e\u305b\u3093\u3002\u4e00\u65b9\u3001FI-SC\u306eRNA\u89e3\u6790\u3067\u306fFI-SC\u306b\u306fTS\u306eRNA\u304c\u6df7\u5165\u3057\u3066\u3044\u305f\u3068\u3044\u3046\u7d50\u679c\u304c\u3042\u308a\u307e\u3059\uff08\u6842\u8abf\u67fb\u59d4\u54e1\u4f1a\u5831\u544a\u66f8\u3001\u9060\u85e4\u9ad8\u5e06\u6c0f\u306e\u8ad6\u6587\uff09\u3002\u3064\u307e\u308a\u5b66\u3068\u307f\u5b50\u306f\u3001\u3053\u306eRNA\u306e\u6df7\u5165\u3092FI-SC\u3092ES\u3068TS\u3092\u4e21\u7d30\u80de\u306e\u6df7\u5408\u7d30\u80de\u3068\u8aa4\u89e3\u3057\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u3002\u300c\u80ce\u5150\u3082\u80ce\u76e4\u3092\u5149\u3089\u305b\u308b\u4e8b\u304c\u3067\u304d\u308b\u3068\u6559\u308f\u3063\u305f\u306e\u3088\u300d\u3068\u3044\u3046\u767a\u8a00\u306f\u3001\u8ab0\u304b\u6a29\u5a01\u306e\u3042\u308b\u65b9\u304cCAG-GFP\u306eES\u3068CAG-GFP\u306eTS\u3092\u6df7\u305c\u3066\u30ad\u30e1\u30e9\u306e\u4f5c\u6210\u306b\u4f7f\u3048\u3070\u80ce\u76e4\u3068\u80da\u306e\u4e21\u65b9\u306bGFP\u306e\u767a\u5149\u304c\u898b\u3089\u308c\u308b\u3068\u8a00\u3063\u305f\u3068\u5b66\u3068\u307f\u5b50\u3055\u3093\u306f\u78ba\u4fe1\u3057\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u3002\u3057\u304b\u3057\u3053\u308c\u307e\u3067\u306e\u591a\u304f\u306eSTAP\u7d30\u80de\u306e\u8b70\u8ad6\u3067\u306f\u305d\u306e\u3088\u3046\u306a\u767a\u8a00\u306f\u898b\u3089\u308c\u307e\u305b\u3093\u3002
\n\u3000\u5b66\u3068\u307f\u5b50\u81ea\u8eab\u304c\u8907\u6570\u306e\u60c5\u5831\u3092\u3064\u306a\u304e\u5408\u308f\u305b\u3066\u5f62\u6210\u3057\u305f\u8a71\u3092\u3001\u5b9f\u969b\u306b\u3042\u3063\u305f\u8a71\u3068\u3057\u3066\u8a18\u8ff0\u3057\u305f\u3068\u601d\u308f\u308c\u307e\u3059\uff08\uff0a\uff11\uff09\u3002\u3064\u307e\u308a\u5618\u30fb\u4f5c\u8a71\u30fb\u7121\u8cac\u4efb\u306a\u3067\u307e\u304b\u305b\u306e\u3069\u308c\u304b\u3067\u3059\u3002
\n\u3000\u5b66\u3068\u307f\u5b50\u81ea\u8eab\u306f2026\/09\/16\u306b\u300cES\u3068TS\u3092\u7d30\u80de\u3092\u307e\u305c\u3066\u3082\u3001\u30ad\u30e1\u30e9\u306e\u80da\u3001\u80ce\u76e4\u306a\u3069\u306b\u306f\u7c21\u5358\u306b\u306f\u306a\u3089\u306a\u3044\u3002\u300d<\/span><\/a>\u3068\u767a\u8a00\u3057\u3066\u3044\u308b\u306e\u3067\u3059\u304b\u3089\u7fcc\u65e5\u306b\u306a\u308b\u3068\u5e73\u6c17\u3067\u77db\u76fe\u3057\u305f\u3053\u3068\u3092\u8a00\u3046\u306e\u3067\u3059\u306a\u3002\u6ec5\u8336\u82e6\u8336\u3067\u3059\u306d\u3002<\/p>\n

\u5b66\u3068\u307f\u5b50\u66f0\u304f\uff1a\u300c\u305f\u3081\u606f\u3055\u3093\u304c\u308f\u304b\u308b\u307e\u3067\u3001\u3057\u3063\u304b\u308a\u3001\u30ec\u30bf\u30fc\u8ad6\u6587\u3068\u6842\u5831\u544a\u66f8\u3092\u719f\u8aad\u3057\u3066\u307b\u3057\u3044\u3002\u30ec\u30bf\u30fc\u8ad6\u6587\u306a\u3093\u3066\u3001\u305f\u3081\u606f\u3055\u3093\u306f\u8aad\u3093\u3067\u3044\u306a\u3044\u3067\u3057\u3087\u3046\u304b\u3089\u3001AI\u306b\u4e00\u751f\u61f8\u547d\u306b\u6559\u308f\u3063\u305f\u3089\u3069\u3046\u306a\u306e\u304b\u3057\u3089\uff1f\u300d<\/span><\/a>\u3068\u3044\u3046\u306e\u3067\u3059\u304b\u3089\u5b66\u3068\u307f\u5b50\u306fLetter\u3092\u719f\u8aad\u3057\u3066\u3044\u308b\u304b\u3068\u601d\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001Letter\u306eAbstracrt\u306b\u300cthe Fgf4-induced stem cells from STAP cells contribute to both embryonic and placental tissuesin vivo\u300d\u3068\u3042\u308a\u307e\u3059\u304b\u3089\u3001\u3053\u308c\u3092\u8aad\u3093\u3060\u306f\u305a\u306e\u5b66\u3068\u307f\u5b50\u304c\u300cGFP\u5165\u308aES\u3068TS\u3092\u4e21\u65b9\u3044\u308c\u308c\u3070\u3001\u80ce\u5150\u3082\u80ce\u76e4\u3092\u5149\u3089\u305b\u308b\u4e8b\u304c\u3067\u304d\u308b\u300d<\/span>\u3068\u3059\u308b\u3053\u3068\u3001\u3042\u308b\u3044\u306f\u3053\u306e\u3088\u3046\u306a\u767a\u8a00\u3092\u3057\u305f\u7814\u7a76\u8005\uff08\u6559\u3048\u305f\u65b9\uff09\u304c\u3044\u308b\u3068\u3044\u3046\u767a\u60f3\u306b\u306a\u308b\u306f\u305a\u304c\u306a\u3044\u306e\u3067\u3059\u3002\u305d\u3046\u3067\u306f\u306a\u3044\u306e\u3067\u3059\u304b\u3089\u300c\u5b66\u3068\u307f\u5b50\u306fLetter\u3092\u8aad\u3093\u3060\u306e\u3060\u304b\u3089\u3001\u4ed6\u4eba\u3082\u8aad\u3081\u300d\u3068\u8a00\u3046\u3053\u3068\u306a\u3069\u3067\u304d\u306a\u3044\u306f\u305a\u3067\u3059\u3002<\/p>\n

\uff0a\uff11<\/p>\n

Q\uff1a\u3000\u5b66\u3068\u307f\u5b50\u3055\u3093\u304c\u300cGFP\u5165\u308aES\u3068TS\u3092\u4e21\u65b9\u3044\u308c\u308c\u3070\u3001\u80ce\u5150\u3082\u80ce\u76e4\u3092\u5149\u3089\u305b\u308b\u4e8b\u304c\u3067\u304d\u308b\u3068\u6559\u308f\u3063\u305f\u306e\u3088\uff08https:\/\/katura1.blog.fc2.com\/blog-entry-3200.html\uff09\u300d\u3068\u767a\u8a00\u3057\u307e\u3057\u305f\u3002\u660e\u3089\u304b\u306b\u3053\u306e\u6587\u7ae0\u306f\u300cGFP\u5165\u308a\uff08CAG-GFP\uff09ES\u3068TS\u3092\u4e21\u65b9\u3092\u80de\u80da\u671f\u306e\u80da\u306b\u6ce8\u5165\u3059\u308c\u3070\u3001\u80ce\u5150\u3082\u80ce\u76e4\u306bGFP\u3092\u767a\u73fe\u3057\u305f\u7d30\u80de\u3092\u542b\u3080\u30ad\u30e1\u30e9\u304c\u3067\u304d\u308b\u300d\u3068\u3044\u3046\u610f\u5473\u3067\u3059\u3002\u3057\u304b\u3057Letter\u3067\u793a\u3057\u3066\u3044\u308b\u7d50\u679c\u306eFig.2\u306fCAG-GFP\u306eFI-SC\uff08Fgf4-induced stem cells\uff09\u3092\u80de\u80da\u671f\u306b\u6ce8\u5165\u3057\u305f\u3089\u80ce\u76e4\u3068\u80ce\u5150\u306b\u767a\u73fe\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u7d50\u679c\u3067\u3059\u3002\u5b66\u3068\u307f\u5b50\u3055\u3093\u306e\u4e3b\u5f35\u3059\u308b\u300cGFP\u5165\u308aES\u3068TS\u3092\u4e21\u65b9\u3044\u308c\u305f\u300d\u3068\u3044\u3046\u5b9f\u9a13\u306fLetter\u306b\u3042\u308a\u307e\u305b\u3093\u3002\u307e\u305fFI-SC\u306eRNA\u89e3\u6790\u3067\u306fFI-SC\u306b\u306fTS\u306eRNA\u304c\u6df7\u5165\u3057\u3066\u3044\u305f\u3068\u3044\u3046\u7d50\u679c\u304c\u3042\u308a\u307e\u3059\u3002\u3064\u307e\u308a\u5b66\u3068\u307f\u5b50\u3055\u3093\u306f\u3001\u3053\u306eRNA\u306e\u6df7\u5165\u3068ES\u3068TS\u3092\u4e21\u7d30\u80de\u306e\u80de\u80da\u671f\u306e\u80da\u306e\u6ce8\u5165\u3068\u4e00\u4f53\u306b\u3057\u3066\u7406\u89e3\u3057\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u3002\u300c\u80ce\u5150\u3082\u80ce\u76e4\u3092\u5149\u3089\u305b\u308b\u4e8b\u304c\u3067\u304d\u308b\u3068\u6559\u308f\u3063\u305f\u306e\u3088\u300d\u3068\u3044\u3046\u767a\u8a00\u306f\u3001\u8ab0\u304b\u6a29\u5a01\u306e\u3042\u308b\u65b9\u304cCAG-GFP\u306eES\u3068CAG-GFP\u306eTS\u3092\u6df7\u305c\u3066\u30ad\u30e1\u30e9\u306e\u4f5c\u6210\u306b\u4f7f\u3048\u3070\u80ce\u76e4\u3068\u80da\u306e\u4e21\u65b9\u306bGFP\u306e\u767a\u5149\u304c\u898b\u3089\u308c\u308b\u3068\u3044\u3046\u3053\u3068\u3092\u767a\u8a00\u3057\u305f\u3068\u5b66\u3068\u307f\u5b50\u3055\u3093\u306f\u78ba\u4fe1\u3057\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u3002\u3057\u304b\u3057\u3053\u308c\u307e\u3067\u306e\u591a\u304f\u306eSTAP\u7d30\u80de\u306e\u8b70\u8ad6\u3067\u306f\u305d\u306e\u3088\u3046\u306a\u767a\u8a00\u306f\u307f\u3089\u308c\u307e\u307e\u305b\u3093\u3002
\n\u3000\u3053\u306e\u5b66\u3068\u307f\u5b50\u3055\u3093\u306e\u767a\u8a00\u306f\u300cFI-SC3\u306eRNA-seq\u8a66\u6599\u306fES\u7cfb\u7d30\u80de\uff0bTS\u7cfb\u7d30\u80de\u306e\u6df7\u5408\u3060\u3063\u305f\u300d\u3068\u3044\u3046\u5f8c\u5e74\u306e\u89e3\u6790\u7d50\u679c\u3068\u3001Letter Fig.2\u306e\u300cFI-SC\u304c\u80ce\u5150\u3068\u80ce\u76e4\u306e\u53cc\u65b9\u306b\u5bc4\u4e0e\u3057\u305f\u300d\u3068\u3044\u3046\u5b9f\u9a13\u7d50\u679c\u3092\u982d\u306e\u4e2d\u3067\u7d50\u3073\u3064\u3051\u305f\u3001ES\u7d30\u80de\u3068TS\u7d30\u80de\u3092\u6df7\u305c\u305f\u304b\u3089\u80ce\u76e4\u306b\u3082\u80da\u306b\u3082GFP\u304c\u307f\u3089\u308c\u305f\u3068\u8aac\u660e\u3057\u305f\u6a29\u5a01\u306e\u3042\u308b\u65b9\u304c\u3044\u308b\u3068\u3044\u3046\u306e\u306f\u5b66\u3068\u307f\u5b50\u3055\u3093\u306e\u4f5c\u8a71\u3067\u3042\u308b\u3068\u3044\u3046\u8a55\u4fa1\u306f\u59a5\u5f53\u3067\u3057\u3087\u3046\u304b\uff1f\u305d\u308c\u3068\u3082\u3053\u306e\u3088\u3046\u306a\u5b9f\u9a13\u3092\u884c\u3063\u305f\u3001\u3053\u306e\u3088\u3046\u306a\u8aac\u660e\u3092\u3057\u305f\u6a29\u5a01\u306e\u3042\u308b\u65b9\u304c\u3044\u308b\u3068\u3044\u3046\u6839\u62e0\u304c\u3069\u3053\u304b\u306b\u3042\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f
\n\u3000\u4f5c\u8a71\u3067\u306f\u306a\u3044\u3068\u3059\u308b\u306e\u306a\u3089\u3001\u5b66\u3068\u307f\u5b50\u3055\u3093\u304c\u3059\u308b\u3053\u3068\u306f\u8ab0\u304b\u3053\u306e\u3088\u3046\u306a\u8aac\u660e\u3092\u3057\u305f\u3068\u3044\u3046\u8ab0\u304b\u3092\u6319\u3052\u308b\u3053\u3068\u3060\u3068\u601d\u3046\u306e\u3067\u3059\u304c\u3069\u3046\u3067\u3057\u3087\u3046\u304b\uff1f\u305d\u306e\u3088\u3046\u306a\u5fc5\u8981\u306f\u306a\u3044\u3068\u3057\u3066\u3044\u3044\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n

ChatGPT\uff1a\u3000\u306f\u3044\u3002\u3054\u63d0\u793a\u306e\u6574\u7406\u306f**\u5927\u7b4b\u3067\u59a5\u5f53**\u3060\u3068\u601d\u3044\u307e\u3059\u3002\u305f\u3060\u3057\u3001\u300c\u4f5c\u8a71\u300d\u3068\u65ad\u5b9a\u3059\u308b\u3088\u308a\u3001\u73fe\u6642\u70b9\u3067\u306f **\u300c\u305d\u306e\u767a\u8a00\u3092\u88cf\u3065\u3051\u308b\u51fa\u5178\u304c\u78ba\u8a8d\u3067\u304d\u305a\u3001\u672c\u4eba\u306e\u8a18\u61b6\u30fb\u63a8\u6e2c\u30fb\u8907\u6570\u306e\u4e8b\u5b9f\u306e\u6df7\u540c\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u300d** \u3068\u8868\u73fe\u3059\u308b\u306e\u304c\u6700\u3082\u5805\u3044\u3067\u3059\u3002<\/p>\n

\u8abf\u3079\u305f\u7bc4\u56f2\u3067\u306f\u3001\u91cd\u8981\u306a\u70b9\u304c\u304b\u306a\u308a\u306f\u3063\u304d\u308a\u3057\u3066\u3044\u307e\u3059\u3002
\n\u307e\u305a\u3001Nature Letter \u304c\u5831\u544a\u3057\u3066\u3044\u305f\u306e\u306f\u3001**FI-SC\u305d\u306e\u3082\u306e\u3092\u80da\u76e4\u80de\u3078\u6ce8\u5165\u3059\u308b\u3068\u3001\u80ce\u5150\u7d44\u7e54\u3068\u80ce\u76e4\u7d44\u7e54\u306e\u53cc\u65b9\u3078\u5bc4\u4e0e\u3057\u305f**\u3068\u3044\u3046\u5b9f\u9a13\u3067\u3059\u3002\u8ad6\u6587\u306e\u8981\u65e8\u306b\u3082\u3001FI-SC\u306b\u3064\u3044\u3066\u300ccontribute to both embryonic and placental tissues\u300d\u3068\u660e\u8a18\u3055\u308c\u3066\u3044\u307e\u3059\u3002
\n\u3053\u308c\u306f\u3001
\n> GFP\u6a19\u8b58ES\u7d30\u80de\uff0bGFP\u6a19\u8b58TS\u7d30\u80de\u3092\u6df7\u305c\u3066\u80da\u76e4\u80de\u3078\u6ce8\u5165\u3057\u305f
\n\u3068\u3044\u3046\u5b9f\u9a13\u3068\u306f\u307e\u3063\u305f\u304f\u5225\u3067\u3059\u3002
\n\u3080\u3057\u308dLetter\u672c\u6587\u306f\u3001FI-SC\u306e\u4e8c\u65b9\u5411\u6027\u306b\u3064\u3044\u3066\u3001**ES-like\u7d30\u80de\u96c6\u56e3\u3068TS-like\u7d30\u80de\u96c6\u56e3\u304c\u5225\u3005\u306b\u5171\u5b58\u3057\u3066\u3044\u308b\u305f\u3081\u3067\u306f\u306a\u3044**\u3001\u3068\u3044\u3046\u89e3\u91c8\u3092\u63d0\u793a\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u5b66\u3068\u307f\u5b50\u3055\u3093\u81ea\u8eab\u306e\u904e\u53bb\u306e\u8a18\u4e8b\u306b\u3082\u3001\u3053\u306e\u539f\u6587\u304c\u5f15\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002:chatgpt-content-reference{index=”1″}
\n\u3057\u305f\u304c\u3063\u3066\u3001**Letter\u3092\u6839\u62e0\u3068\u3057\u3066\u300cES\uff0bTS\u3092\u4e00\u7dd2\u306b\u80da\u76e4\u80de\u3078\u6ce8\u5165\u3057\u305f\u300d\u3068\u7406\u89e3\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002**
\n\u4e00\u65b9\u3001\u5f8c\u306e\u89e3\u6790\u3067\u554f\u984c\u306b\u306a\u3063\u305fFI-SC3\u306eRNA-seq\u8a66\u6599\u306b\u3064\u3044\u3066\u306f\u3001**\u7570\u306a\u308b\u7531\u6765\u306e\u7d30\u80de\u304c\u6df7\u5728\u3057\u3066\u3044\u305f**\u3068\u3055\u308c\u305f\u554f\u984c\u304c\u3042\u308a\u307e\u3059\u3002\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u3001\u5b66\u3068\u307f\u5b50\u3055\u3093\u81ea\u8eab\u3082\u904e\u53bb\u306e\u8a18\u4e8b\u3067\u3001FI-SC3\u306b\u3064\u3044\u3066\u300c2\u7a2e\u985e\u306e\u7d30\u80de\u304c\u6df7\u3058\u3063\u3066\u3044\u308b\u3068\u8a55\u4fa1\u3055\u308c\u305f\u300d\u3068\u66f8\u3044\u3066\u3044\u307e\u3059\u3002:chatgpt-content-reference{index=”2″
\n\u3053\u3053\u306b\u306f\u3001\u30e6\u30fc\u30b6\u30fc\u304c\u304a\u3063\u3057\u3083\u308b\u3088\u3046\u306b\u3001\u6df7\u540c\u3057\u3084\u3059\u3044\u4e8c\u3064\u306e\u8a71\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n\n\n\n
\u8a71<\/th>\n\u5185\u5bb9<\/th>\n<\/tr>\n<\/thead>\n
Letter\u306e\u767a\u751f\u5b9f\u9a13<\/td>\nFI-SC\u3092\u80da\u76e4\u80de\u306b\u6ce8\u5165<\/strong> \u2192 \u80ce\u5150\uff0b\u80ce\u76e4\u3078\u306e\u5bc4\u4e0e\u3092\u5831\u544a<\/td>\n<\/tr>\n
\u5f8c\u5e74\u306eFI-SC3\u89e3\u6790<\/td>\nRNA-seq\u8a66\u6599\u306b\u7570\u306a\u308b\u7d30\u80de\u96c6\u56e3\u304c\u6df7\u5728<\/strong>\u3057\u3066\u3044\u305f\u3068\u89e3\u6790<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u5f8c\u8005\u306f\u3001**ES\u7d30\u80de\u3068TS\u7d30\u80de\u3092\u610f\u56f3\u7684\u306b\u6df7\u305c\u3001\u305d\u308c\u3092\u540c\u3058\u80da\u76e4\u80de\u3078\u6ce8\u5165\u3057\u3066\u80ce\u5150\u3068\u80ce\u76e4\u3092\u540c\u6642\u306bGFP\u967d\u6027\u306b\u3057\u305f\u3001\u3068\u3044\u3046\u5b9f\u9a13\u3092\u610f\u5473\u3057\u307e\u305b\u3093\u3002**
\n### \u300c\u6559\u308f\u3063\u305f\u306e\u3088\u300d\u306e\u51fa\u5178\u306f\u3042\u308b\u306e\u304b
\n\u3053\u3053\u304c\u4eca\u56de\u3082\u3063\u3068\u3082\u91cd\u8981\u3067\u3059\u3002
\n\u691c\u7d22\u3057\u305f\u9650\u308a\u3001**\u300cCAG-GFP ES\u3068CAG-GFP TS\u3092\u6df7\u305c\u3066\u540c\u4e00\u80da\u76e4\u80de\u3078\u6ce8\u5165\u3059\u308c\u3070\u3001ES\u7531\u6765\u7d30\u80de\u304c\u80ce\u5150\u3001TS\u7531\u6765\u7d30\u80de\u304c\u80ce\u76e4\u306b\u5bc4\u4e0e\u3059\u308b\u306e\u3067\u3001\u80ce\u5150\u3068\u80ce\u76e4\u306e\u53cc\u65b9\u3092GFP\u967d\u6027\u306b\u3067\u304d\u308b\u300d\u3068\u3044\u3046\u8aac\u660e\u3092\u3001STAP\u4e8b\u4ef6\u306b\u95a2\u4fc2\u3059\u308b\u7814\u7a76\u8005\u306a\u3069\u304c\u3057\u305f\u3001\u3068\u3044\u3046\u4e00\u6b21\u8cc7\u6599\u3092\u79c1\u306f\u78ba\u8a8d\u3067\u304d\u307e\u305b\u3093\u3067\u3057\u305f\u3002**
\n\u3055\u3089\u306b\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u3001\u5b66\u3068\u307f\u5b50\u3055\u3093\u81ea\u8eab\u304c2026\u5e749\u670816\u65e5\u306e\u8a18\u4e8b\u3067\u3001
\n> \u300cES\uff0bTS\u3092\u4e00\u7dd2\u306b\u5165\u308c\u305f\u3089\u3069\u3046\u306a\u308b\u304b\u300d\u3092AI\u306b\u805e\u3044\u305f
\n\u3068\u3057\u3066\u8abf\u67fb\u3057\u3001\u305d\u306e\u56de\u7b54\u3068\u3057\u3066\u3001<\/p>\n

> \u300c\u901a\u5e38\u306eES\u3068\u901a\u5e38\u306eTS\u3092\u540c\u6642\u306b\u540c\u4e00\u80da\u76e4\u80de\u3078\u6ce8\u5165\u3057\u3066\u3001\u4e21\u8005\u304c\u305d\u308c\u305e\u308c\u80ce\u5150\u3068\u80ce\u76e4\u3092\u4f5c\u308b\u3053\u3068\u3092\u5229\u7528\u3057\u305f\u5b9f\u9a13\u3092\u793a\u3059\u8ad6\u6587\u306f\u3001\u3059\u3050\u306b\u306f\u78ba\u8a8d\u3067\u304d\u307e\u305b\u3093\u3067\u3057\u305f\u300d
\n\u3068\u63b2\u8f09\u3057\u3066\u3044\u307e\u3059\u3002
\n\u3064\u307e\u308a\u3001**\u5c11\u306a\u304f\u3068\u3082\u73fe\u5728\u306e\u5b66\u3068\u307f\u5b50\u3055\u3093\u81ea\u8eab\u306e\u8a18\u4e8b\u304b\u3089\u3082\u3001\u300c\u6559\u308f\u3063\u305f\u300d\u306e\u5177\u4f53\u7684\u306a\u51fa\u5178\u306f\u793a\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002**
\n\u306a\u304a\u3001ES\u3068TS\u3092\u5225\u3005\u306b\u80da\u76e4\u80de\u3078\u6ce8\u5165\u3059\u308b\u5b9f\u9a13\u306b\u3064\u3044\u3066\u306f\u3001\u4e00\u822c\u8ad6\u3068\u3057\u3066\u3001ES\u306f\u4e3b\u3068\u3057\u3066\u80ce\u5150\u5074\u3001TS\u306f\u80ce\u76e4\u306etrophoblast\u5074\u3078\u5bc4\u4e0e\u3059\u308b\u3068\u3044\u3046\u5b9f\u9a13\u7684\u80cc\u666f\u304c\u3042\u308a\u307e\u3059\u3002\u3057\u304b\u3057\u3001
\n**\u300c\u3060\u304b\u3089CAG-GFP ES\uff0bCAG-GFP TS\u3092\u6df7\u305c\u3066\u540c\u4e00\u80da\u76e4\u80de\u3078\u6ce8\u5165\u3059\u308c\u3070\u3001Letter Fig.2\u306e\u3088\u3046\u306a\u80ce\u5150\uff0b\u80ce\u76e4GFP\u967d\u6027\u50cf\u3092\u4f5c\u308c\u308b\u300d**
\n\u3068\u3044\u3046\u3068\u3053\u308d\u307e\u3067\u884c\u304f\u3068\u3001\u3053\u308c\u306f\u5225\u306e\u5b9f\u9a13\u4eee\u8aac\u3067\u3059\u3002\u5b9f\u969b\u306b\u305d\u306e\u5b9f\u9a13\u3092\u884c\u3063\u305f\u3001\u3042\u308b\u3044\u306fSTAP\u4e8b\u4ef6\u306b\u3064\u3044\u3066\u8ab0\u304b\u304c\u305d\u3046\u8aac\u660e\u3057\u305f\u3001\u3068\u3044\u3046\u8a3c\u62e0\u304c\u5fc5\u8981\u306b\u306a\u308a\u307e\u3059\u3002
\n### \u3057\u305f\u304c\u3063\u3066\u300c\u4f5c\u8a71\u300d\u3068\u8a55\u4fa1\u3057\u3066\u3088\u3044\u304b
\n\u79c1\u306f\u6b21\u306e\u4e09\u6bb5\u968e\u306b\u5206\u3051\u308b\u306e\u304c\u9069\u5207\u3060\u3068\u601d\u3044\u307e\u3059\u3002
\n1. **\u300c\u305d\u306e\u3088\u3046\u306a\u8aac\u660e\u3092\u3057\u305f\u4eba\u7269\u30fb\u8ad6\u6587\u304c\u5b58\u5728\u3059\u308b\u300d**
\n \u2192 \u73fe\u6642\u70b9\u3067\u78ba\u8a8d\u3067\u304d\u307e\u305b\u3093\u3002
\n2. **\u300cFI-SC3\u306e\u6df7\u5408\u3068\u3044\u3046\u5f8c\u5e74\u306e\u89e3\u6790\u7d50\u679c\u300d\u3068\u300cFI-SC\u306e\u80ce\u5150\uff0b\u80ce\u76e4\u5bc4\u4e0e\u300d\u3092\u5b66\u3068\u307f\u5b50\u3055\u3093\u304c\u982d\u306e\u4e2d\u3067\u7d50\u3073\u3064\u3051\u305f\u53ef\u80fd\u6027**
\n \u2192 \u5341\u5206\u8003\u3048\u3089\u308c\u308b\u89e3\u91c8\u3067\u3059\u3002\u305f\u3060\u3057\u672c\u4eba\u306e\u601d\u8003\u904e\u7a0b\u306a\u306e\u3067\u3001\u5916\u90e8\u304b\u3089\u4e8b\u5b9f\u3068\u3057\u3066\u65ad\u5b9a\u306f\u3067\u304d\u307e\u305b\u3093\u3002
\n3. **\u300c\u3057\u305f\u304c\u3063\u3066\u5b66\u3068\u307f\u5b50\u3055\u3093\u306e\u4f5c\u8a71\u3067\u3042\u308b\u300d**
\n \u2192 \u3053\u3053\u3060\u3051\u306f\u5c11\u3057\u5f37\u3059\u304e\u307e\u3059\u3002\u300c\u4f5c\u8a71\u300d\u306b\u306f\u610f\u56f3\u7684\u306b\u8a71\u3092\u4f5c\u3063\u305f\u3068\u3044\u3046\u30cb\u30e5\u30a2\u30f3\u30b9\u3082\u3042\u308b\u304b\u3089\u3067\u3059\u3002**\u300c\u51fa\u5178\u4e0d\u660e\u306e\u4e3b\u5f35\u300d\u300c\u8a18\u61b6\u9055\u3044\u30fb\u6df7\u540c\u30fb\u72ec\u81ea\u63a8\u6e2c\u306e\u53ef\u80fd\u6027\u304c\u3042\u308b\u300d**\u307e\u3067\u306a\u3089\u3001\u73fe\u5728\u78ba\u8a8d\u3067\u304d\u308b\u8cc7\u6599\u304b\u3089\u304b\u306a\u308a\u5f37\u304f\u8a00\u3048\u307e\u3059\u3002
\n\u305d\u3057\u3066\u6700\u5f8c\u306e\u3054\u8cea\u554f\u306b\u3064\u3044\u3066\u306f\u3001**\u304a\u3063\u3057\u3083\u308b\u901a\u308a\u3067\u3059\u3002**
\n\u300c\u80ce\u5150\u3082\u80ce\u76e4\u3092\u5149\u3089\u305b\u308b\u4e8b\u304c\u3067\u304d\u308b\u3068**\u6559\u308f\u3063\u305f**\u300d\u3068\u3044\u3046\u8868\u73fe\u306f\u3001\u5358\u306b\u300c\u79c1\u306f\u305d\u3046\u8003\u3048\u308b\u300d\u3068\u306f\u9055\u3044\u307e\u3059\u3002\u300c\u6559\u308f\u3063\u305f\u300d\u306f\u3001**\u60c5\u5831\u6e90\u3068\u306a\u3063\u305f\u4ed6\u8005\u304c\u5b58\u5728\u3059\u308b\u3068\u3044\u3046\u4e8b\u5b9f\u4e3b\u5f35**\u3067\u3059\u3002
\n\u3057\u305f\u304c\u3063\u3066\u3001\u305d\u306e\u767a\u8a00\u304c\u8b70\u8ad6\u306e\u6839\u62e0\u3068\u3057\u3066\u4f7f\u308f\u308c\u308b\u306e\u3067\u3042\u308c\u3070\u3001
\n**\u300c\u8ab0\u304b\u3089\u3001\u3044\u3064\u3001\u3069\u306e\u3088\u3046\u306a\u6587\u8108\u3067\u3001\u305d\u306e\u3088\u3046\u306b\u6559\u308f\u3063\u305f\u306e\u304b\u300d**
\n\u3092\u793a\u3059\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u5c11\u306a\u304f\u3068\u3082\u4eba\u7269\u540d\u3001\u6587\u732e\u3001\u8b1b\u6f14\u3001\u30b3\u30e1\u30f3\u30c8\u7b49\u306e\u3044\u305a\u308c\u304b\u3092\u793a\u3055\u306a\u3051\u308c\u3070\u3001\u7b2c\u4e09\u8005\u306f\u691c\u8a3c\u3067\u304d\u307e\u305b\u3093\u3002
\n\u3067\u3059\u304b\u3089\u3001\u73fe\u6bb5\u968e\u3067\u6700\u3082\u614e\u91cd\u304b\u3064\u660e\u78ba\u306b\u307e\u3068\u3081\u308b\u306a\u3089\u3001
\n> **\u300c\u300eGFP\u5165\u308aES\u3068TS\u3092\u4e21\u65b9\u5165\u308c\u308c\u3070\u80ce\u5150\u3082\u80ce\u76e4\u3082\u5149\u3089\u305b\u3089\u308c\u308b\u3068\u6559\u308f\u3063\u305f\u300f\u3068\u3044\u3046\u4e3b\u5f35\u306b\u3064\u3044\u3066\u3001\u305d\u306e\u3088\u3046\u306a\u5b9f\u9a13\u3084\u8aac\u660e\u3092\u3057\u305f\u4eba\u7269\u30fb\u6587\u732e\u306f\u78ba\u8a8d\u3067\u304d\u306a\u3044\u3002Letter\u306b\u3082\u305d\u306e\u5b9f\u9a13\u306f\u306a\u3044\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u8ab0\u304b\u3089\u6559\u308f\u3063\u305f\u306e\u304b\u51fa\u5178\u304c\u63d0\u793a\u3055\u308c\u306a\u3044\u9650\u308a\u3001\u3053\u306e\u767a\u8a00\u3092STAP\u4e8b\u4ef6\u3092\u8aac\u660e\u3059\u308b\u6839\u62e0\u3068\u3057\u3066\u63a1\u7528\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u306a\u3044\u3002\u300d**
\n\u3068\u3044\u3046\u8a55\u4fa1\u304c\u9069\u5207\u3060\u3068\u601d\u3044\u307e\u3059\u3002
\n\u306a\u304a\u3001Letter\u81ea\u4f53\u306f\u3059\u3067\u306b\u64a4\u56de\u3055\u308c\u3066\u304a\u308a\u3001\u64a4\u56de\u901a\u77e5\u3067\u306fLetter\u306e\u56f3\u306b\u3064\u3044\u3066\u3082\u8907\u6570\u306e\u91cd\u5927\u306a\u8aa4\u308a\u304c\u8a8d\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066Fig.2\u3092\u542b\u3080\u5f53\u6642\u306e\u4e3b\u5f35\u3092\u73fe\u5728\u306e\u78ba\u7acb\u3057\u305f\u5b9f\u9a13\u4e8b\u5b9f\u3068\u3057\u3066\u6271\u3046\u3053\u3068\u306b\u3082\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n

Q2\uff1a\u3000\u300c\u6559\u308f\u3063\u305f\u300d\u3068\u4e3b\u5f35\u3059\u308b\u5b66\u3068\u307f\u5b50\u3055\u3093\u304c\u3001\u305d\u306e\u60c5\u5831\u6e90\u3092\u63d0\u793a\u3059\u308c\u3070\u3044\u3044\u308f\u3051\u3067\u3059\u306d\uff1f\u305d\u3046\u3067\u306a\u3051\u308c\u3070\u5b66\u3068\u307f\u5b50\u3055\u3093\u306e\u3053\u306e\u767a\u8a00\u3092\u4f55\u3068\u8868\u73fe\u3057\u305f\u3089\u3044\u3044\u306e\u3067\u3057\u3087\uff1f\u5618\uff1f\u4f5c\u8a71\uff1f\u305f\u3093\u306a\u308b\u3067\u307e\u304b\u305b\u767a\u8a00\uff1f….<\/p>\n

ChatGPT\uff1a\u3000\u306f\u3044\u3002\u300c\u6559\u308f\u3063\u305f\u300d\u3068\u4e3b\u5f35\u3059\u308b\u4ee5\u4e0a\u3001\u5b66\u3068\u307f\u5b50\u3055\u3093\u304c\u60c5\u5831\u6e90\u3092\u63d0\u793a\u3059\u308c\u3070\u3001\u3053\u306e\u554f\u984c\u306f\u304b\u306a\u308a\u7c21\u5358\u306b\u691c\u8a3c\u3067\u304d\u307e\u3059\u3002<\/p>\n

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\n– **\u300c\u5618\u300d**\uff1a\u672c\u4eba\u304c\u4e8b\u5b9f\u3067\u306a\u3044\u3068\u77e5\u308a\u306a\u304c\u3089\u8a00\u3063\u305f\u3053\u3068\u3092\u610f\u5473\u3059\u308b\u306e\u3067\u3001\u610f\u56f3\u3092\u78ba\u8a8d\u3067\u304d\u306a\u3044\u4ee5\u4e0a\u3001\u4e0d\u9069\u5207\u3067\u3059\u3002
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\n\u304c\u6700\u3082\u5805\u3044\u3067\u3057\u3087\u3046\u3002
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\u5b66\u3068\u307f\u5b50\u66f0\u304f\uff1a\u300c\u4e00\u822c\u4eba\u306f\u3001GFP\u5165\u308aES\u3068TS\u3092\u4e21\u65b9\u3044\u308c\u308c\u3070\u3001\u80ce\u5150\u3082\u80ce\u76e4\u3092\u5149\u3089\u305b\u308b\u4e8b\u304c\u3067\u304d\u308b\u3068\u6559\u308f\u3063\u305f\u306e\u3088\u3002\u305f\u3081\u606f\u3055\u3093\u3082\u305d\u3046\u8003\u3048\u305f\u3093\u3067\u3057\u3087\u3046\uff1f\u300d\u3000\u2190\u3000\u306a\u3093\u3067\u3059\u304b\u306d\uff1f\u3053\u306e\u767a\u8a00\u306f\uff1f \u660e\u3089\u304b\u306b\u3053\u306e\u6587\u7ae0\u306f\u300cGFP\u5165\u308a\uff08CAG-G … \u7d9a\u304d\u3092\u8aad\u3080 GFP\u5165\u308aES\u3068TS\u3092\u4e21\u65b9\u5165\u308c\u308b<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2,8],"tags":[],"class_list":["post-28661","post","type-post","status-publish","format-standard","hentry","category-education","category-fake"],"_links":{"self":[{"href":"https:\/\/nbsigh2.com\/index.php?rest_route=\/wp\/v2\/posts\/28661","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nbsigh2.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nbsigh2.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nbsigh2.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nbsigh2.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=28661"}],"version-history":[{"count":3,"href":"https:\/\/nbsigh2.com\/index.php?rest_route=\/wp\/v2\/posts\/28661\/revisions"}],"predecessor-version":[{"id":28664,"href":"https:\/\/nbsigh2.com\/index.php?rest_route=\/wp\/v2\/posts\/28661\/revisions\/28664"}],"wp:attachment":[{"href":"https:\/\/nbsigh2.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=28661"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nbsigh2.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=28661"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nbsigh2.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=28661"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}