{"id":27495,"date":"2025-12-18T10:11:09","date_gmt":"2025-12-18T01:11:09","guid":{"rendered":"https:\/\/nbsigh2.com\/?p=27495"},"modified":"2025-12-25T13:52:51","modified_gmt":"2025-12-25T04:52:51","slug":"%e3%81%93%e3%82%8c%e3%81%a0%e3%81%91%e6%8c%87%e6%91%98%e3%81%95%e3%82%8c%e3%81%a6%e3%82%82%e6%94%b9%e8%a8%82%e3%81%97%e3%81%aa%e3%81%84%e3%81%ae%e3%81%af%e4%bd%95%e6%95%85%e3%81%a7%e3%81%97%e3%82%87","status":"publish","type":"post","link":"https:\/\/nbsigh2.com\/?p=27495","title":{"rendered":"\u3053\u308c\u3060\u3051\u6307\u6458\u3055\u308c\u3066\u3082\u6539\u3081\u306a\u3044\u306e\u306f\u4f55\u6545\u3067\u3057\u3087\uff1f"},"content":{"rendered":"

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\u554f\u984c\u306e\u4e39\u7fbd\u6c0f\u7dcf\u8aac\u306b\u3042\u308b\u82f1\u6587\u306f\u3001\u5b66\u3068\u307f\u5b50\u304c\u3064\u3051\u305f\u6587\u5b57\u306e\u8272<\/a>\u3092\u305d\u306e\u307e\u307e\u306b\u3057\u3066\u793a\u3059\u3068\u3001
\nAmong the TFs of the TSC-specific network, the evolutionarily conserved functions of Sox2, Eomes and Cdx2 are found in neuroectoderm, mesoendoderm and definitive endoderm, respectively<\/span>, but they cooperate together to define an evolutionarily new cell type, the trophoblast. <\/strong><\/span>
\n\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n

\u3053\u306e\u82f1\u6587\u306e\u6700\u521d\uff08 2020\/09\/28 \uff09\u306e\u5b66\u3068\u307f\u5b50\u306e\u89e3\u8aac\u306f\u300cTS\u306b\u7279\u7570\u7684\u306a\u8ee2\u5199\u56e0\u5b50\u304c\u3001\u4e09\u80da\u8449\u5206\u5316\u306b\u95a2\u4fc2\u3057\u3066\u3044\u304f\u3068\u66f8\u3044\u3066\u3042\u308a\u307e\u3059\u3002\u7d2b\u5b57\u90e8\u5206\u3067\u3059\u3002\u300d<\/span><\/a>\u3067\u3057\u305f\u3002\u3053\u306e\u8a18\u4e8b\u306f\u554f\u984c\u306e\u82f1\u6587\u306e\u524d\u306e\u8a18\u8ff0\u300cIn addition, the combined activity of multiple TFs on a super-enhancer to recruit the Mediator complex could make it relatively straightforward to achieve new synergistic functions among a novel combination of TFs. These events would enable a new combination of TFs in the network to be established, which in turn could lead to the specification of an evolutionarily novel cell type. \u300d\u3092\u300c\u305d\u308c\u305e\u308c\u306e\u7570\u306a\u308b\u8ee2\u5199\u56e0\u5b50\u304c\u7d44\u5408\u308f\u3055\u3063\u3066\u30d8\u30c6\u30ed\u30c0\u30a4\u30de\u30fc\u3068\u306a\u308b\u3053\u3068\u3067\u3001\u7d50\u5408\u3059\u308bDNA\u5869\u57fa\u6570\u306e\u9078\u629e\u6027\u3068affinity\u304c\u5897\u3057\u3001\u78ba\u5b9f\u306b\u30bf\u30fc\u30b2\u30c3\u30c8\u907a\u4f1d\u5b50\u767a\u73fe\u306b\u5411\u3051\u3066\u50cd\u304d\u307e\u3059\u3002\u300d<\/span>\u3068\u89e3\u8aac\u3057\u305f\u5f8c\u306e\u8a18\u8ff0\u3067\u3001\u3042\u3063\u3055\u308a\u3068\u66f8\u3044\u3066\u307e\u3059\u3002\u305d\u3082\u305d\u3082\u3053\u306e\u4e39\u7fbd\u6c0f\u8ad6\u6587\u306e\u7d39\u4ecb\u52d5\u6a5f\u306f\u300c\u3059\u3067\u306b\u4e39\u7fbd\u7dcf\u8aac\u306e\u8208\u5473\u6df1\u3044\u70b9\u306b\u3064\u3044\u3066\u8aac\u660e\u6e08\u307f\u3060\u304c\u3001\u4ee5\u4e0b\u306e\u8a18\u8f09\u3082\u3001\u54fa\u4e73\u985e\u304c\u80ce\u76e4\u3092\u7372\u5f97\u3057\u305f\u3053\u3068\u3067\u3001\u591a\u5f69\u306a\u7d30\u80de\u7a2e\u3092\u7372\u5f97\u3067\u304d\u305f\u3068\u66f8\u3044\u3066\u3042\u308b\u306e\u3067\u3001\u8208\u5473\u3042\u308b\u4eba\u306f\u8aad\u3093\u3067\u307b\u3057\u3044\u3002\u300d<\/span>\u3068\u3044\u3046\u3053\u3068\u306a\u3093\u3067\u3059\u304c\u3001\u3053\u306e\u8aac\u660e\u3082\u30c7\u30bf\u30e9\u30e1\u3067\u3059\u3002\u4e39\u7fbd\u6c0f\u306f\u300c\u54fa\u4e73\u985e\u304c\u80ce\u76e4\u3092\u7372\u5f97\u3057\u305f\u3053\u3068\u3067\u3001\u591a\u5f69\u306a\u7d30\u80de\u7a2e\u3092\u7372\u5f97\u3067\u304d\u305f\u300d\u306a\u3069\u3068\u8a00\u3063\u3066\u3044\u307e\u305b\u3093\u3002\u3053\u3093\u306a\u3053\u3068\u3092\u8a00\u3046\u308f\u3051\u304c\u306a\u3044\u3067\u3057\u3087\u3046\u3002
\n\u3000\u30d8\u30c6\u30ed\u30c0\u30a4\u30de\u30fc\u3068\u3044\u3046\u5358\u8a9e\u3092\u4f7f\u3063\u3066\u3044\u308b\u306e\u3082\u9593\u9055\u3044\u3067\u3059\u3002\u30d8\u30c6\u30ed\u30c0\u30a4\u30de\u30fc\u306e\u30c0\u30a4\u30de\u30fc\u3068\u306f\u65e5\u672c\u8a9e\u3067\u306f\u4e8c\u91cf\u4f53\u3068\u3044\u3046\u3088\u3046\u306b\uff12\u3064\u306e\u5206\u5b50\u306e\u7d50\u5408\u3057\u3066\uff11\u5206\u5b50\u306b\u306a\u3063\u305f\u3082\u306e\u3067\u3059\u3002\u540c\u3058\u5206\u5b50\uff12\u500b\u304c\u7d50\u5408\u3057\u305f\u3089\u30db\u30e2\u30c0\u30a4\u30de\u30fc\u3001\u3061\u3087\u3068\u9055\u3046\uff12\u5206\u5b50\u304c\u7d50\u5408\u3057\u305f\u306e\u3092\u30d8\u30c6\u30ed\u30c0\u30a4\u30de\u30fc\u3068\u3044\u3046\u308f\u3051\u3067\u3059\u3002multiple TFs\u304csuper-enhancer\u306b\u7d50\u5408\u3057\u3066the Mediator complex\u3068\u306a\u308b\u3088\u3046\u306a\u5834\u5408\u306f\u30c0\u30a4\u30de\u30fc\u3068\u3044\u3046\u8a00\u8449\u3092\u4f7f\u3046\u306e\u306f\u9593\u9055\u3044\u3067\u3059\u3002\u305d\u3082\u305d\u3082\uff12\u500b\u306e\u5206\u5b50\u306e\u7d50\u5408\u3067\u306f\u306a\u3044\u306e\u3067\u3059\u304b\u3089\u306d\u3002
\n\u3000\u3053\u3046\u3044\u3046\u30c7\u30bf\u30e9\u30e1\u304c\u66f8\u3044\u3066\u3042\u308b\u306e\u3067\u3059\u304c\u3001\u4eca\u56de\u306e\u554f\u984c\u306f\u300cTS\u306b\u7279\u7570\u7684\u306a\u8ee2\u5199\u56e0\u5b50<\/b>\u300d<\/span>\u3068\u3057\u305f\u3053\u3068\u3067\u3059\u3002\u7279\u7570\u7684\u306a\u8ee2\u5199\u56e0\u5b50\u306a\u3069\u4e39\u7fbd\u6c0f\u306f\u66f8\u3044\u3066\u306a\u3044\u306e\u3067\u3059\u3002<\/p>\n

\u4e39\u7fbd\u6c0f\u306e\u6587\u7ae0\u306b\u306f\uff13\u3064\u306e\u65e2\u5b58\u306e\u8ee2\u5199\u56e0\u5b50\u304c\u5354\u8abf\u3057\u3066\u50cd\u304f\u3068\u3044\u3046\u8aac\u660e\u306a\u306e\u3067\u3059\u304b\u3089\u3001\u7279\u7570\u7684\u306a\u8ee2\u5199\u56e0\u5b50\u304c\u3042\u308b\u308f\u3051\u3067\u306f\u306a\u3044\u306e\u3067\u3059\u3002\u3055\u3089\u306b\u3053\u306e\u7279\u7570\u7684\u8ee2\u5199\u56e0\u5b50\u304c\u300c\u4e09\u80da\u8449\u5206\u5316\u306b\u95a2\u4fc2\u3057\u3066\u3044\u304f\u300d<\/span>\u306a\u3069\u3068\u306f\u3053\u306e\u82f1\u6587\u304b\u3089\u8aad\u307f\u53d6\u308c\u308b\u308f\u3051\u304c\u306a\u3044\u306e\u3067\u3059\u3002<\/p>\n

\u305d\u3053\u3067\u5f53\u65b9\u304c\u3053\u306e\u5b66\u3068\u307f\u5b50\u306e\u8aac\u660e\u3092\uff082020\u5e749\u670828\u65e5 21:42\uff09\u306b\u30c7\u30bf\u30e9\u30e1\u3001\u5618\u3092\u66f8\u304f\u306a<\/a>\u3068\u6307\u6458\u3057\u305f\u308f\u3051\u3067\u3059\u3002\u3055\u3089\u306b\u5b66\u3068\u307f\u5b50\u304c\u8d64\u5b57\u3067\u793a\u3057\u305f\u82f1\u6587\u306f\u3001\u3053\u306e\u8a18\u8ff0\u3067\u4e3b\u5f35\u3057\u3066\u3044\u308b\u91cd\u8981\u70b9\u3067\u306f\u306a\u304f\u3001\u305d\u306e\u524d\u306e\u300cthey cooperate together to define \u300d\u306e\u307b\u3046\u304c\u4e3b\u5f35\u3057\u3066\u3044\u308b\u70b9\u3067\u3042\u308b\u3068\u3082\u6307\u6458\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u3053\u306e\u5f53\u65b9\u306e\u6307\u6458\u3092\u8aad\u3093\u3060\u5b66\u3068\u307f\u5b50\u304c\u3001\u7fcc\u65e5\u306e2020\/09\/29 \u306b\u300cTS\u306b\u4fdd\u5b58\u3055\u308c\u305f\u8ee2\u5199\u56e0\u5b50Sox2, Eomes Cdx2 \u304c\u3001\u305d\u306e\u5f8c\u306e\u5185\u3001\u4e2d\u3001\u5916\u306e\uff13\u80da\u8449\u7cfb\u306e\u7d30\u80de\u5206\u5316\u3001neuroectoderm, mesoendoderm\u3001definitive endoderm\u3000\u306b\u5f15\u304d\u7d99\u304c\u308c\u3066\u3044\u308b\u3068\u66f8\u304b\u308c\u3066\u3044\u308b\u306e\u304c\u3001\u7d2b\u5b57\u90e8\u5206\u3067\u3059\u3002\u8aad\u307f\u65b9\u306b\u9593\u9055\u3048\u3088\u3046\u304c\u7121\u3044\u8a18\u8f09\u90e8\u5206\u3067\u3059\u3002\u300d<\/span><\/a>\u3068\u8a18\u8f09\u3057\u305f\u306e\u3067\u3059\u3002<\/p>\n

\u3053\u306e\u610f\u8a33\u3068\u3044\u3046\u304b\u89e3\u8aac\u3042\u308b\u3044\u306f\u8aac\u660e\u3068\u3044\u3046\u306e\u304b\u3001\u8a18\u8ff0\u304c\u554f\u984c\u306b\u306a\u308a\u3001\uff15\u5e74\u7d4c\u904e\u3057\u3066\u3082\u5b66\u3068\u307f\u5b50\u306f\u81ea\u5206\u306e\u9593\u9055\u3044\u3092\u8a02\u6b63\u3059\u308b\u3053\u3068\u304c\u306a\u3044\u306e\u3067\u554f\u984c\u306b\u306a\u3063\u3066\u3044\u308b\u308f\u3051\u3067\u3059\u3002<\/p>\n

\u3053\u306e\u82f1\u6587\u306e\u8aa4\u8a33\u306e\u539f\u56e0\u306f
\n\u2460among \u306e\u610f\u5473
\n\u2461conserved\u306e\u610f\u5473
\n\u2462are found \u306e\u610f\u5473
\n\u2463but \u306e\u610f\u5473
\n\u3092\u5b66\u3068\u307f\u5b50\u304c\u7406\u89e3\u3067\u304d\u3066\u306a\u3044\u3053\u3068\u306b\u3042\u308a\u307e\u3059\u3002\u3068\u304f\u306b but \u306e\u610f\u5473\u3067\u3059\u3002\uff15\u5e74\u524d\u306e\u30b3\u30e1\u30f3\u30c8<\/a>\u3067\u3082\u66f8\u3044\u3066\u3044\u307e\u3059\u304c\u3001\u5b66\u3068\u307f\u5b50\u306b\u306f\u8ad6\u7406\u7684\u306a\u601d\u8003\u80fd\u529b\u306b\u6b20\u9665\u304c\u3042\u3063\u3066\u3001\u8ad6\u7406\u3092\u7e4b\u3050\u5358\u8a9e\u306e\u610f\u5473\u304c\u7406\u89e3\u3067\u304d\u306a\u3044\u306e\u3067\u3059\u3002\u554f\u984c\u306e\u8a18\u4e8b<\/a>\u3067\u3082<\u300c\u4e0a\u8a18\u6587\u7ae0\u306fHowever\u306e\u524d\u304c\u5927\u4e8b\u3067\u3059\u3002\u300d<\/span>\u3068\u66f8\u3044\u3066\u3044\u308b\u3088\u3046\u306b\u3001but \u3068\u304b however \u3068\u3044\u3046\u5358\u8a9e\u306e\u8ad6\u7406\u7684\u306a\u610f\u5473\u304c\u308f\u304b\u3063\u3066\u306a\u3044\u306e\u3067\u3059\u3002\u666e\u901a\u306e\u65b9\u306b\u3068\u3063\u3066\u306f\u5f53\u7136\u306e\u3053\u3068\u3067\u3059\u304c\u3001but \u3068\u304b\u3000however \u3068\u3044\u3046\u5358\u8a9e\u304c\u3042\u3063\u305f\u3089\u3001\u65e5\u672c\u8a9e\u3067\u3082\u300c\u3057\u304b\u3057\u300d\u3068\u304b\u300c\u3057\u304b\u3057\u306a\u304c\u3089\u300d\u3068\u3042\u3063\u305f\u3089\u3001\u3053\u306e\u5358\u8a9e\u306e\u524d\u306b\u3042\u308b\u3053\u3068\u3092\u5426\u5b9a\u3057\u3066\u305d\u306e\u5f8c\u306e\u8a18\u8ff0\u3092\u5f37\u8abf\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3001\u3053\u306e\u5358\u8a9e\u306e\u5f8c\u306e\u8a18\u8ff0\u304c\u4e3b\u5f35\u306e\u4e3b\u306a\u70b9\u306a\u308f\u3051\u3067\u3059\u3002\u5b66\u3068\u307f\u5b50\u306b\u306f\u3053\u306e\u8a18\u8ff0\u306e\u610f\u5473\u3059\u308b\u3053\u3068\u304c\u7406\u89e3\u3067\u304d\u306a\u3044\u306e\u3067\u3059\u3002<\/p>\n

\u3067\u3059\u304b\u3089\u3001\u554f\u984c\u306e\u6587\u7ae0\u3067\u4e39\u7fbd\u6c0f\u304c\u4e3b\u5f35\u3057\u305f\u3044\u306e\u306f\u2463\u306ebut\u4ee5\u4e0b\u306e\u8a18\u8ff0\u300cbut they cooperate together to define an evolutionarily new cell type, the trophoblast. \u300d\u306a\u308f\u3051\u3067\u3059\u3002\u4e3b\u5f35\u306f\u5b66\u3068\u307f\u5b50\u304c\u8d64\u5b57\u3067\u5f37\u8abf\u3057\u305f\u300cevolutionarily new cell type, the trophoblast.\u300d\u3067\u306f\u306a\u3044\u306e\u306f\u660e\u3089\u304b\u3067\u3059\u3002Trophoblast\u6804\u990a\u819c\u3001\u306e\u3061\u306e\u80ce\u76e4\u3068\u306a\u308b\u7d44\u7e54\u304c\u9032\u5316\u7684\u306b\u65b0\u3057\u3044\u7d44\u7e54\uff08\u7d30\u80de\uff09\u3067\u3042\u308b\u306e\u306f\u3001\u4e39\u7fbd\u6c0f\u304c\u8a00\u308f\u306a\u304f\u3066\u3082\u5e38\u8b58\u3067\u3059\u304b\u3089\u3001\u3053\u308c\u3092\u3053\u306e\u8ee2\u5199\u56e0\u5b50\u306e\u7dcf\u8aac\u3067\u6539\u3081\u3066\u4e3b\u5f35\u3059\u308b\u3053\u3068\u3067\u306f\u306a\u304f\u3001\u300cthey cooperate together\u300d\u304c\u4e3b\u5f35\u306e\u4e3b\u306a\u70b9\u306a\u308f\u3051\u3067\u3059\u3002<\/p>\n

\u3053\u306e\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3001they \u304c\u4f55\u3092\u793a\u3057\u3066\u3044\u308b\u306e\u304b\u304c\u308f\u304b\u308c\u3070\u3001\u3053\u306e\u82f1\u6587\u3092\u8aa4\u8a33\u3059\u308b\u3053\u3068\u306f\u3042\u308a\u3048\u306a\u3044\u306e\u3067\u3059\u3002\u5b66\u3068\u307f\u5b50\u306fbut\u4ee5\u4e0b\u304c\u91cd\u8981\u3067\u3042\u308b\u3068\u3044\u3046\u3001\u4e2d\u5b66\u751f\u3067\u3082\u308f\u304b\u308b\u8ad6\u7406\u304c\u7406\u89e3\u3067\u304d\u3066\u306a\u3044\u306e\u3067\u3059\u306d\u3002<\/p>\n

\u3067\u306fthey \u304c\u4f55\u3092\u6307\u3059\u304b\u3068\u3044\u3046\u3068\u3001\u305d\u306e\u524d\u306b\u66f8\u3044\u3066\u3042\u308b\u8907\u6570\u306e\u7269\u8cea\u3068\u306f\uff13\u3064\u306e\u8ee2\u5199\u56e0\u5b50\u3057\u304b\u306a\u3044\u304b\u3089\u3001\u3059\u3050\u308f\u304b\u308a\u307e\u3059\u3002\uff13\u3064\u306e\u8ee2\u5199\u56e0\u5b50\u304c\u5354\u8abf\u3057\u3066\u9032\u5316\u7684\u306b\u65b0\u3057\u3044Trophoblast\u6804\u990a\u819c\u3092define\u3057\u305f\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308b\u308f\u3051\u3067\u3059\u3002\u3053\u306edefine\u3068\u3044\u3046\u52d5\u8a5e\u306f\u300c\u5b9a\u7fa9\u3059\u308b\u300d\u3068\u3044\u3046\u610f\u5473\u3067\u3059\u304c\u3001\u305d\u306e\u307e\u307e\u5b9a\u7fa9\u3059\u308b\u3067\u306f\u65e5\u672c\u8a9e\u3068\u3057\u3066\u9055\u548c\u611f\u304c\u3042\u308b\u306e\u3067\u3001oTake\u3055\u3093\u304c\u8b70\u8ad6\u3055\u308c\u3066\u3044\u308b<\/a>\u3088\u3046\u306b\u3001\u6c7a\u5b9a\u3059\u308b\u3001\u6210\u7acb\u3055\u305b\u308b\u3068\u304b\u4f5c\u308a\u4e0a\u3052\u308b\u3068\u304b\u306b\u3059\u308c\u3070\u3044\u3044\u306e\u3067\u3059\u3002\u3053\u308c\u304c\u3053\u306e\u82f1\u6587\u306e\u6700\u3082\u91cd\u8981\u306a\u4e3b\u5f35\u306a\u308f\u3051\u3067\u3001\u5b66\u3068\u307f\u5b50\u306f\u5927\u4e8b\u3060\u3068\u8d64\u5b57\u3067\u793a\u3057\u3066\u3044\u308b\u3068\u3053\u308d\u304c\u91cd\u8981\u306a\u306e\u3067\u306f\u306a\u3044\u306e\u3067\u3059\u3002but \u3092\u7406\u89e3\u3067\u304d\u306a\u3044\u306e\u3067\u9593\u9055\u3048\u305f\u306e\u3067\u3059\u306d\u3002<\/p>\n

\u2460\u306eamong\u3068\u2461\u306econserve \u306f\u8fd1\u63a5\u3057\u305f\u90e8\u4f4d\u306b\u3042\u308b\u306e\u3067\u3001\u3053\u306e\u5358\u8a9e\u306e\u65e5\u672c\u8a9e\u306e\u610f\u5473\u304b\u3089\u5b66\u3068\u307f\u5b50\u306f\u52dd\u624b\u306b\u300c\u306a\u304b\u306b\u4fdd\u5b58\u3055\u308c\u305f\u300d\u3068\u3057\u3061\u3083\u3063\u305f\u306e\u3067\u3059\u306d\u3002\u3064\u307e\u308a\u300cTS\u306b\u4fdd\u5b58\u3055\u308c\u305f\u8ee2\u5199\u56e0\u5b50\u300d\u3068\u3057\u305f\u306e\u3067\u3059\u3002conserve\u306f\u4fdd\u5b58\u306e\u610f\u5473\u3067\u9593\u9055\u3044\u306a\u3044\u306e\u3067\u3059\u304c\u300cthe evolutionarily conserved functions\u300d\u3067\u300c\u9032\u5316\u7684\u306b\u4fdd\u5b58\u3055\u308c\u305f\uff08\uff13\u3064\u306e\u8ee2\u5199\u56e0\u5b50\u306e\uff09\u6a5f\u80fd\u300d\u306a\u3093\u3067\u3059\u304b\u3089\u3001\u8ee2\u5199\u56e0\u5b50\u304c\u4fdd\u5b58\u3055\u308c\u305f\u306e\u3067\u306f\u306a\u304f\u3001\u9032\u5316\u7684\u306b\u4fdd\u305f\u308c\u3066\u304d\u305f\u8ee2\u5199\u56e0\u5b50\u306e\u6a5f\u80fd\u3068\u3044\u3046\u610f\u5473\u306a\u306e\u3067\u3059\u3002\u3057\u304b\u3057\u5b66\u3068\u307f\u5b50\u306f\u4fdd\u5b58\u3055\u308c\u305f\u306e\u3060\u304b\u3089\u3069\u3053\u304b\u306b\u4fdd\u5b58\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u306b\u306a\u308b\u308f\u3051\u3067\u3001\u305d\u306e\u5834\u6240\u306fTS\u3067\u3042\u308b\u3068\u6c7a\u3081\u3064\u3051\u305f\u308f\u3051\u3067\u3059\u3002
\n\u3000\u6c7a\u3081\u3064\u3051\u308b\u7406\u7531\u306f\u300cAmong the TFs\u300d\u3092\u300cTFs\uff08\u8ee2\u5199\u56e0\u5b50\uff09\u306e\u4e2d\u300d\u3053\u308c\u3067\u306f\u610f\u5473\u304c\u308f\u304b\u3089\u306a\u3044\u306e\u3067\u3001TS\uff08\u6804\u990a\u819c\u5e79\u7d30\u80de\uff09\u3068\u3057\u3061\u3083\u3063\u305f\u306e\u3067\u3059\u306d\u3002\u3069\u3053\u304b\u3092\u3053\u306e\u82f1\u6587\u306e\u4e2d\u3067\u63a2\u3059\u3053\u3068\u304c\u3067\u304d\u306a\u3044\u306e\u3067\u3001\u9032\u5316\u7684\u306b\u65b0\u3057\u3044\u7d44\u7e54TS\u306b\u3057\u3061\u3083\u3063\u305f\u306e\u3067\u3059\u3002among \u3092\u3000\u4e2d\u306b\u3000\u3068\u65e5\u672c\u8a9e\u306b\u66f8\u304d\u63db\u3048\u305f\u306e\u3067\u3000\u8907\u6570\u306e\u5019\u88dc\u304b\u3089\uff11\u3064\u3092\u9078\u3076\u3068\u3044\u3046\u3088\u3046\u306a\u4f7f\u3044\u65b9\u3067\u300c\u4e2d\u304b\u3089\u300d\u3068\u3044\u3046\u610f\u5473\u306a\u3093\u3067\u3059\u304c\u3001\u5834\u6240\u306e\u4e2d\u306b\u3001\u5185\u90e8\u306b\u3068\u3057\u305f\u3093\u3067\u3059\u306a\u3002\u65e5\u672c\u8a9e\u306b\u7f6e\u304d\u63db\u3048\u305f\u306e\u3067\u9593\u9055\u3048\u3001\u306a\u304a\u304b\u3064TFs\u3092TS\u306b\u3057\u3061\u3083\u3063\u305f\u306e\u3067\u3059\u3002<\/p>\n

\u3068\u3059\u308b\u3068\u6b21\u306b\u554f\u984c\u306b\u306a\u308b\u306e\u306fare found \u3092\u3069\u306e\u3088\u3046\u306b\u8a33\u3057\u305f\u3089\u3044\u3044\u306e\u304b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002TS\u306e\u5185\u90e8\u306b\u3042\u308b\uff13\u3064\u306e\u8ee2\u5199\u56e0\u5b50\u304c\u4e09\u80da\u8449\u306bfound \u898b\u3064\u304b\u308b\u3067\u306f\u3001\u3044\u304f\u3089\u306a\u3093\u3067\u3082\u304a\u304b\u3057\u3044\u306e\u3067\u3001\u3053\u3053\u3092\u300c\u5f15\u304d\u7d99\u304c\u308c\u3066\u3044\u308b\u300d\u3068\u3059\u308c\u3070\u3001\u5185\u5bb9\u306f\u30c7\u30bf\u30e9\u30e1\u3067\u3059\u304c\u300c\uff13\u3064\u306e\u8ee2\u5199\u56e0\u5b50\u304c\u5f15\u304d\u7d99\u304c\u308c\u308b\u300d\u3068\u3057\u3066\u3082\u65e5\u672c\u8a9e\u306e\u6587\u6cd5\u3068\u3057\u3066\u306f\u554f\u984c\u306a\u3044\u308f\u3051\u3067\u3059\u3002\u3053\u308c\u3067\u5b66\u3068\u307f\u5b50\u81ea\u8eab\u306f\u7406\u89e3\u3067\u304d\u305f\u3068\u7d0d\u5f97\u3057\u3061\u3083\u305f\u3093\u3067\u3059\u306d\u3002are found \u306b\u300c\u5f15\u304d\u7d99\u304c\u308c\u308b\u300d\u3068\u3044\u3046\u610f\u5473\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u4e2d\u5b66\u82f1\u8a9e\u3067\u300c\u898b\u3064\u304b\u308b\u300d\u300c\u767a\u898b\u3055\u308c\u308b\u300d\u306e\u610f\u5473\u3067\u3059\u304b\u3089\u3001\u3053\u306e\u5834\u5408\u300c\u5b58\u5728\u3059\u308b\u306e\u304c\u5224\u660e\u3059\u308b\u300d\uff1d\u300c\u5b58\u5728\u3059\u308b\u300d\u3068\u3044\u3046\u610f\u5473\u306b\u306a\u308b\u306e\u306f\u660e\u3089\u304b\u3067\u3059\u3002\u3064\u307e\u308a\u9032\u5316\u7684\u306b\u4fdd\u5b58\u3055\u308c\u305f\uff08\u53e4\u304f\u304b\u3089\u3042\u308b\uff09\uff13\u3064\u306e\u8ee2\u5199\u56e0\u5b50\u306f\u4e09\u80da\u8449\u306b\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3001are found \u3067\uff13\u3064\u306e\u8ee2\u5199\u56e0\u5b50\u306e\u7279\u5fb4\u3092\u8a18\u8f09\u3057\u3066\u3044\u308b\u306e\u3067\u3001\u300c\u9032\u5316\u7684\u306b\u6614\u304b\u3089\u3042\u308b\uff13\u3064\u306e\u8ee2\u5199\u56e0\u5b50\u306f\u4e09\u80da\u8449\u306b\u3042\u308b\u300d\u3068\u8a33\u305b\u3070\u3044\u3044\u306e\u3067\u3059\u3002<\/p>\n

\u3053\u308c\u3089\u306e\u6307\u6458\u304c\uff15\u5e74\u524d\u304b\u3089\u73fe\u5728\u306eoTake\u3055\u3093\u306e\u30b3\u30e1\u30f3\u30c8\u3067\u3082\u884c\u308f\u308c\u3066\u304d\u305f\u306e\u3067\u3059\u304c\u3001\u5b66\u3068\u307f\u5b50\u306f\u6307\u6458\u304c\u7406\u89e3\u3067\u304d\u305a\u3001\u8a02\u6b63\u3059\u308b\u3053\u3068\u306f\u306a\u3044\u306e\u3067\u3059\u3002<\/p>\n

\u3055\u3089\u306b\u6065\u3092\u6652\u3057\u305f\u3053\u3068\u306b\u3001\u300c\u4f8b\u3048\u3070\u4ee5\u4e0b\u306e\u5b66\u3068\u307f\u5b50\u6587\u7ae0
\n\u300cTS\u306b\u4fdd\u5b58\u3055\u308c\u305f\u8ee2\u5199\u56e0\u5b50Sox2, Eomes Cdx2 \u304c\u3001\u305d\u306e\u5f8c\u306e\u5185\u3001\u4e2d\u3001\u5916\u306e\uff13\u80da\u8449\u7cfb\u306e\u7d30\u80de\u5206\u5316\u3001neuroectoderm, mesoendoderm\u3001definitive endoderm\u3000\u306b\u5f15\u304d\u7d99\u304c\u308c\u3066\u3044\u308b\u300d\u3053\u3053\u306b\u3001\u5b66\u3068\u307f\u5b50\u8aac\u660e\u306b\u6cbf\u3063\u3066\u3001\u8a00\u8449\u3092\u88dc\u3048\u3070\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u3068\u306a\u308a\u3001\u3053\u308c\u306f\u6b63\u89e3\u306b\u306a\u308a\u307e\u3059\u3002\u300cTS\u306b\u4fdd\u5b58\u3055\u308c\u305f\u8ee2\u5199\u56e0\u5b50Sox2, Eomes Cdx2 \u304c\u3001\u80da\u767a\u751f\u5f8c\u306e\u5185\u3001\u4e2d\u3001\u5916\u306e\uff13\u80da\u8449\u7cfb\u306e\u7d30\u80de\u5206\u5316\u3001neuroectoderm, mesoendoderm\u3001definitive endoderm\u306e\u8ee2\u5199\u56e0\u5b50\u306b\u5f15\u304d\u7d99\u304c\u308c\u3066\u3044\u308b\u300d\u4e00\u822c\u4eba\u306a\u3089\u3001\u6700\u5f8c\u306e\u6587\u7bc0\u306e\u300c\u306b\u300d\u3092\u300c\u304b\u3089\u300d\u306b\u3059\u308b\u3068\u308f\u304b\u308a\u3084\u3059\u3044\u304c\u3001\u300c\u306b\u300d\u3067\u3082\u610f\u5473\u306f\u901a\u3058\u307e\u3059\u3002\u305f\u3081\u606f\u30d6\u30ed\u30b0\u306b\u77e5\u8b58\u304c\u3042\u308c\u3070\u3001\u80ce\u76e4\u306e\u5f8c\u306e\u4e09\u80da\u8449\u3068\u306f\u8aad\u307f\u307e\u305b\u3093\u3002\u300d<\/span><\/a>\u3068\u6700\u8fd1\u3001\u66f8\u304d\u52a0\u3048\u305f\u306e\u3067\u3059\u3002\u3064\u307e\u308a\u300c\uff13\u3064\u306e\u8ee2\u5199\u56e0\u5b50\u306f\u4e09\u80da\u8449\u306b<\/b>\u5f15\u304d\u7d99\u304c\u308c\u308b\u300d\u3068\u3044\u3046\u306e\u306f\u4eca\u307e\u3067\u3068\u5909\u308f\u308a\u304c\u306a\u3044\u306e\u3067\u3059\u304c\u3001\u3053\u308c\u3092\u300c\uff13\u3064\u306e\u8ee2\u5199\u56e0\u5b50\u306f\u4e09\u80da\u8449\u304b\u3089<\/b>\u5f15\u304d\u7d99\u304c\u308c\u308b\u300d\u3068\u3059\u308b\u3068span style=”color: #0000ff;”>\u300c\u308f\u304b\u308a\u3084\u3059\u3044\u304c\u3001\u610f\u5473\u306f\u901a\u3058\u308b\u3000\u300d<\/span>\u3001\u3064\u307e\u308a\u540c\u3058\u3060\u3068\u3044\u3046\u308f\u3051\u3067\u3059\u3002\u301c\u306b\u3000\u3068\u301c\u304b\u3089\u3000\u3067\u306f\u610f\u5473\u304c\u5168\u304f\u9006\u306b\u306a\u308b\u306e\u304c\u308f\u304b\u3089\u306a\u3044\u306e\u3067\u3059\u304b\u306d\uff1f\u65e5\u672c\u8a9e\u3067\u3059\u3088\uff1f<\/p>\n

\u300cTS\u306b\u4fdd\u5b58\u3055\u308c\u305f\u8ee2\u5199\u56e0\u5b50Sox2, Eomes Cdx2 \u304c\u3001\u80da\u767a\u751f\u5f8c\u306e\u5185\u3001\u4e2d\u3001\u5916\u306e\uff13\u80da\u8449\u7cfb\u306e\u7d30\u80de\u5206\u5316\u3001neuroectoderm, mesoendoderm\u3001definitive endoderm\u306e\u8ee2\u5199\u56e0\u5b50\u306b\uff08\u304b\u3089\uff09\u5f15\u304d\u7d99\u304c\u308c\u3066\u3044\u308b\u300d
\n<\/span>\u3067\u306f\u5f53\u65b9\u7b49\u306e\u6307\u6458\u3092\u5168\u304f\u7406\u89e3\u3067\u304d\u3066\u306a\u3044\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\uff13\u3064\u306e\u8ee2\u5199\u56e0\u5b50\u306fTS\u306b\u4fdd\u5b58\u3055\u308c\u305f\u3082\u306e\u3067\u3082\u306a\u304f\u3001\u5f15\u304d\u7d99\u304c\u308c\u308b\u3082\u306e\u3067\u3082\u306a\u3044\u306e\u3067\u3059\u3002<\/p>\n

\u5b66\u3068\u307f\u5b50\u304c\u8aa4\u8a33\u3057\u305f\u539f\u56e0\u306f\u3001\u82f1\u6587\u306b\u3042\u308b\u5358\u8a9e\u3092\u65e5\u672c\u8a9e\u306b\u7f6e\u304d\u63db\u3048\u3001\u305d\u306e\u65e5\u672c\u8a9e\u306e\u4e26\u3073\u3092\u5b66\u3068\u307f\u5b50\u306e\u5984\u60f3\u30b9\u30c8\u30fc\u30ea\u30fc\u306b\u6cbf\u3063\u305f\u610f\u5473\u304c\u901a\u308b\u304b\u306e\u3088\u3046\u306b\u7e4b\u3052\u5408\u308f\u305b\u305f\u3053\u3068\u306b\u3042\u308a\u307e\u3059\u3002\u610f\u5473\u304c\u901a\u308b\u3088\u3046\u306b\u3059\u308b\u305f\u3081\u306b\u306fare found \u306e\u3088\u3046\u306a\u52d5\u8a5e\u90e8\u5206\u3092\u5b66\u3068\u307f\u5b50\u306e\u30b9\u30c8\u30fc\u30ea\u30fc\u306b\u5408\u308f\u305b\u308b\u3088\u3046\u306b\u610f\u5473\u3092\u5909\u3048\u308b\u5fc5\u8981\u304c\u3042\u308b\u306e\u3067\u3059\u3002\u306a\u306b\u304bSTAP\u4e8b\u4ef6\u306e\u3001\u30ad\u30e1\u30e9\u304c\u3067\u304d\u305f\u3068\u3044\u3046\u4e8b\u5b9f\uff08\u4e8b\u5b9f\u3067\u306f\u306a\u304b\u3063\u305f\u306e\u3067\u3059\u304c\u5f53\u6642\u306f\u4e8b\u5b9f\u3068\u8a8d\u8b58\u3055\u308c\u3066\u3044\u305f\uff09\u306b\u5408\u308f\u305b\u308b\u3088\u3046\u306b\u3001\u7d30\u80de\u5897\u6b96\u5b9f\u9a13\u7d50\u679c\u3082\u30e1\u30c1\u30eb\u5316\u306e\u8abf\u67fb\u306e\u7d50\u679c\u3082\u4f5c\u308a\u4e0a\u3052\u305f\u3068\u3044\u3046\u306e\u306b\u3088\u304f\u4f3c\u3066\u3044\u307e\u3059\u306a\u3002<\/p>\n

\u305d\u308c\u3067\u306f\u3069\u3046\u8a33\u3059\u306e\u304b\uff1f\u3068\u3044\u308f\u308c\u305d\u3046\u306a\u306e\u3067\u6848\u3092\u3002
\n\u300c\u6804\u990a\u819c\u5e79\u7d30\u80de\u7279\u7570\u7684\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u306b\u542b\u307e\u308c\u308b\u8907\u6570\u306e\u8ee2\u5199\u56e0\u5b50\u306e\u4e2d\u3067\u3082\u3001Sox2\u3001Eomes\u3001Cdx2 \u306f\u305d\u308c\u305e\u308c\u5916\u80da\u8449\u3001\u4e2d\u80da\u8449\u30fb\u5185\u80da\u8449\u306b\u304a\u3044\u3066\u9032\u5316\u7684\u306b\u4fdd\u5b58\u3055\u308c\u305f\u6a5f\u80fd\u3092\u6301\u3064\u304c\u3001\u3053\u308c\u3089\u304c\u5354\u8abf\u3057\u3066\u50cd\u304f\u3053\u3068\u306b\u3088\u308a\u3001\u9032\u5316\u7684\u306b\u65b0\u3057\u3044\u7d30\u80de\u578b\u3067\u3042\u308b\u6804\u990a\u819c\u304c\u6c7a\u5b9a\u3055\u308c\u308b\u3002\u300d
\n\u3067\u306f\u3069\u3046\u3067\u3057\u3087\uff1f\u4e09\u80da\u8449\u306f\u300cneuroectoderm, mesoendoderm and definitive endoderm\u300d\u306a\u3093\u3067\u3059\u304c\u3001\u306f\u3057\u3087\u3063\u3061\u3083\u3044\u307e\u3057\u305f\u3002\u6b63\u78ba\u306b\u306f\u795e\u7d4c\u5916\u80da\u8449\u3001\u4e2d\u5185\u80da\u8449\u3001\u78ba\u5b9a\u5185\u80da\u8449\u3068\u3059\u3079\u304d\u3067\u3059\u304b\u306d\u3002<\/p>\n

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