{"id":19319,"date":"2021-12-03T13:16:05","date_gmt":"2021-12-03T04:16:05","guid":{"rendered":"https:\/\/nbsigh2.com\/?p=19319"},"modified":"2024-07-14T15:10:57","modified_gmt":"2024-07-14T06:10:57","slug":"are-found","status":"publish","type":"post","link":"https:\/\/nbsigh2.com\/?p=19319","title":{"rendered":"are found …"},"content":{"rendered":"

\u5b66\u3068\u307f\u5b50\u306e\u30d6\u30ed\u30b0\u306b\u66f8\u3044\u3066\u3042\u308b\u30c7\u30bf\u30e9\u30e1\u3001\u7279\u306b\u82f1\u8a9e\u8ad6\u6587\u7d39\u4ecb\u306e\u30c7\u30bf\u30e9\u30e1\u306e\u539f\u56e0\u306f
\n\u2460\u6b63\u3057\u3044\u65e5\u672c\u8a9e\u306e\u8868\u73fe\u304c\u3067\u304d\u306a\u3044
\n\u2461\u82f1\u8a9e\u3092\u307e\u3068\u3082\u306b\u7406\u89e3\u3067\u304d\u306a\u3044
\n\u306e\u3069\u3061\u3089\u304b\u3001\u3042\u308b\u3044\u306f\u4e21\u65b9\u304b\u3068\u601d\u308f\u308c\u307e\u3059\u3002<\/p>\n

\u2460\u306e\u6b63\u3057\u3044\u65e5\u672c\u8a9e\u304c\u4f7f\u3048\u306a\u3044\u3068\u3044\u3046\u306e\u306f\u3001\u56fd\u5185\u6700\u9ad8\u306e\u6559\u80b2\u3092\u53d7\u3051\u3001\u306a\u304a\u304b\u3064\u535a\u58eb\u53f7\u3092\u6709\u3059\u308b\u65b9\u306b\u306f\u305d\u306e\u3088\u3046\u306a\u3053\u3068\u304c\u3042\u308b\u3068\u306f\u4fe1\u3058\u3089\u308c\u306a\u3044\u306e\u3067\u3001\u5b66\u3068\u307f\u5b50\u306e\u6587\u7ae0\u3092\u307e\u3068\u3082\u306b\u89e3\u91c8\u3059\u308b\u308f\u3051\u3067\u3059\u304c\u3001\u3053\u306e\u8003\u3048\u306f\u3053\u308c\u307e\u3067\u4f55\u56de\u3082\u88cf\u5207\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u3002
\n\u2461\u306e\u82f1\u8a9e\u6587\u7ae0\u304c\u307e\u3068\u3082\u306b\u7406\u89e3\u3067\u304d\u306a\u3044\u3068\u3044\u3046\u306e\u306f\u3001\u82f1\u8a9enative\u3067\u306f\u306a\u3044\u304b\u3089\u3057\u3087\u3046\u304c\u306a\u3044\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u304c\u3001\u305d\u308c\u3067\u3082\u82f1\u8a9e\u8ad6\u6587\u306e\u8457\u8005\u306a\u306e\u3060\u304b\u3089\u3042\u308a\u3048\u306a\u3044\u3068\u666e\u901a\u306f\u601d\u3046\u308f\u3051\u3067\u3059\u304c\u3001\u3069\u3046\u3084\u3089\u3053\u308c\u3082\u9055\u3046\u3088\u3046\u3067\u3059\u3002<\/p>\n

\u304b\u3064\u3066\u3001\u305d\u3093\u306a\u8a33\u306f\u30c7\u30bf\u30e9\u30e1\u3060\u3068\u3044\u3046\u8907\u6570\u306e\u65b9\u304b\u3089\u306e\u6307\u6458\u306e\u3042\u3063\u305f\u5b66\u3068\u307f\u5b50\u306e\u8a18\u4e8b\u306f\u3001\u8a02\u6b63\u3055\u308c\u308b\u3053\u3068\u304c\u306a\u3044\u306e\u3067\u3001\u518d\u5ea6\u6301\u3061\u51fa\u3057\u305f\u3068\u3053\u308d\u3001\u8a02\u6b63\u306e\u5fc5\u8981\u306a\u3069\u306a\u304f\u3001\u5f53\u65b9\u7b49\u306e\u6307\u6458\u306e\u65b9\u304c\u8aa4\u308a\u3067\u3042\u308b\u3068\u306e\u8fd4\u4e8b\u3067\u3057\u305f\u3002\u305d\u3053\u3067\u3001\u5b66\u3068\u307f\u5b50\u306e\u8a00\u3044\u5206\u306e\u8ffd\u8a18<\/a>\u306e\u300c\u4eca\u56de\u554f\u984c\u306b\u306a\u3063\u305f\u306e\u306f\u3001\u201d\u5f15\u304d\u7d99\u304c\u308c\u308b\u201d\u306e\u8868\u73fe\u3067\u3059\u3002\u300d<\/span>\u4ee5\u964d\u306e\u8a18\u8ff0\u3068\u3001\u4ee5\u4e0b\u306e\u5f53\u65b9\u306e\u5b66\u3068\u307f\u5b50\u306e\u8aa4\u308a\u3092\u6307\u6458\u3057\u305f\u8a18\u8ff0\u3001\u3069\u3061\u3089\u304c\u6b63\u3057\u3044\u30fb\u8aac\u5f97\u529b\u304c\u3042\u308b\u304b\u3092\u8aad\u8005\u306e\u65b9\u304c\u5224\u65ad\u3057\u3066\u3044\u305f\u3060\u3051\u308c\u3070\u3044\u3044\u304b\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n

\u305d\u3082\u305d\u3082\u306f\u4e39\u7fbd\u6c0f\u306e\u7dcf\u8aac<\/a>\u306e10\u30da\u30fc\u30b8\u76ee\u306b\u3042\u308b\u300cEvolution of the TF network\u300d\u306e\u9805\u306e<\/p>\n

Among the TFs of the TSC-specific network, the evolutionarily conserved functions of Sox2, Eomes and Cdx2 are found in neuroectoderm, mesoendoderm and definitive endoderm,respectively (Box 1, Glossary)<\/span> (Sasai, 2001; Beck and Stringer, 2010; Probst and Arnold, 2017), but they cooperate together to define an evolutionarily new cell type, the trophoblast.<\/span> Such flexibility in the combination of TFs could be a result of the flexible design of a TF network.<\/p><\/blockquote>\n

TF(s):transcription factor(s):\u8ee2\u5199\u56e0\u5b50
\nTSC(s):Trophoblast stem cell(s) \uff1a\u6804\u990a\u819c\u5e79\u7d30\u80de\uff08\u5c06\u6765\u80ce\u76e4\u306e\u80ce\u5150\u5074\u306e\u7d44\u7e54\u3092\u5f62\u6210\u3059\u308b\uff09
\n\u6587\u5b57\u306e\u8272\u306f\u5b66\u3068\u307f\u5b50\u304c\u4ed8\u3051\u307e\u3057\u305f\u3002<\/span>
\n\u306e<\/p>\n

\u5b66\u3068\u307f\u5b50\u306e\u82f1\u8a33\uff082020\/09\/29\uff09<\/a><\/p>\n

TS\u306b\u4fdd\u5b58\u3055\u308c\u305f\u8ee2\u5199\u56e0\u5b50Sox2, Eomes Cdx2 \u304c\u3001\u305d\u306e\u5f8c\u306e\u5185\u3001\u4e2d\u3001\u5916\u306e\uff13\u80da\u8449\u7cfb\u306e\u7d30\u80de\u5206\u5316\u3001neuroectoderm, mesoendoderm\u3001definitive endoderm\u3000\u306b\u5f15\u304d\u7d99\u304c\u308c\u3066\u3044\u308b…\u8aad\u307f\u65b9\u306b\u9593\u9055\u3048\u3088\u3046\u304c\u7121\u3044\u8a18\u8f09\u90e8\u5206\u3067\u3059\u3002<\/p><\/blockquote>\n

\u304c\u554f\u984c\u306a\u306e\u3067\u3059\u3002<\/p>\n

\u5b66\u3068\u307f\u5b50\u306f\u8a33\u3057\u305f\u306e\u3067\u306f\u306a\u3044\u3068\u3044\u3046\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u304c\u3001\u660e\u3089\u304b\u306b\u65e5\u672c\u8a9e\u306b\u8a33\u3057\u3066\u89e3\u8aac\u30fb\u8aac\u660e\u3057\u305f\u3082\u306e\u3067\u3059\u3002\u304b\u3064\u3066\u6307\u6458\u3057\u305f\u3053\u3068\u3067\u3059\u304c\u3001\u3053\u306e\u8a33\u306b\u306f\uff12\u3064\u306e\u8aa4\u308a\u304c\u3042\u308a\u307e\u3059\u3002among…conserved \u3068\u3000are found \u3067\u3059\u3002<\/p>\n

are found \u304b\u3089\u7a81\u3063\u8fbc\u3093\u3067\u307f\u307e\u3059\u3002<\/p>\n

\u4e2d\u5b66\u751f\u304c\u8aad\u3093\u3067\u3082 are found \u306f\u300c\u767a\u898b\u3055\u308c\u305f\u300d\u3068\u3044\u3046\u610f\u5473\u3067\u3059\u3002\u4eca\u56de\u306f\uff13\u3064\u306e\u8ee2\u5199\u56e0\u5b50\u304c\u767a\u898b\u3055\u308c\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3001\u7814\u7a76\u8005\u304c\u767a\u898b\u3057\u3066\u3082\u3001\u3057\u306a\u304f\u3066\u3082\uff13\u3064\u306e\u8ee2\u5199\u56e0\u5b50\u3068\u3044\u3046\u7269\u8cea\u306f\u300c\u5b58\u5728\u3059\u308b\u300d\u3042\u308b\u3044\u306f\u300c\u3042\u308b\u300d\u308f\u3051\u3067\u3059\u304b\u3089\u3001\u300c\uff13\u3064\u306e\u8ee2\u5199\u56e0\u5b50\u306f\u4e09\u80da\u8449\u306b\u3042\u308b\u300d\u3068\u8a33\u3059\u306e\u304c\u6b63\u3057\u3044\u308f\u3051\u3067\u3059\u3002\u3053\u306e\u300care found\u300d\u3092\u5b66\u3068\u307f\u5b50\u306f\u3053\u306e\u3088\u3046\u306b\u8aac\u660e\u3057\u3066\u3044\u307e\u3059<\/a><\/p>\n

\u4f8b\u3048\u3070\u3001are found\u3000\u3092\u3001\u767a\u898b\u3055\u308c\u305f\u3068\u8a33\u305b\u3070\u3001\u305d\u308c\u306f\u30df\u30b9\u3068\u8a00\u308f\u308c\u3066\u3082\u4ed5\u65b9\u306a\u3044\u304c\u3001\u3057\u304b\u3057\u3001\u539f\u6587\u306e\u30cb\u30e5\u30a2\u30f3\u30b9\u306f\u3001\u300c\u3042\u308b\u300d\u4f4d\u306e\u610f\u5473\u3067\u3042\u308b\u3002<\/p><\/blockquote>\n

\u306f\u3044\u3002\u5f53\u65b9\u306e\u610f\u898b\u3068\u306f\u82e5\u5e72\u3061\u304c\u3044\u307e\u3059\u304c\u3001\u305d\u308c\u3067\u3082\u300c\u3042\u308b\u300d\u3068\u8a33\u3059\u306e\u306b\u5b66\u3068\u307f\u5b50\u306f\u7570\u8b70\u3092\u5531\u3048\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n

\u3068\u3053\u308d\u304c\u3001\u306a\u3093\u3068\u3001\u3053\u306e\u5f8c\u306e\u8ffd\u8a18\u3067\u5b66\u3068\u307f\u5b50\u306f\u300care found\u300d\u306f<\/p>\n

\u201d\u3042\u308b\u201d\u201d\u5b58\u5728\u3059\u308b\u201d\u3044\u3046\u610f\u5473\u3067\u306e\u201d\u5f15\u304d\u7d99\u304c\u308c\u308b\u201d\u3067\u3059\u3002
\n\u3082\u3057\u3001\u305d\u3046\u3044\u3046\u53d7\u3051\u3068\u308a\u65b9\u304c\u3067\u304d\u306a\u3044\u306a\u3089\u3000are found\u3000\u306e\u4f7f\u3044\u65b9\u3082\u9593\u9055\u3063\u3066\u3044\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002TS\u304c\u3001\u306e\u3061\u306e\u6a5f\u80fd\u3067\u3042\u308b\u304b\u3089\u3053\u305d\u3001are found\u3000\u304c\u767a\u898b\u306e\u610f\u5473\u306b\u306f\u306a\u308a\u307e\u305b\u3093\u3002<\/p><\/blockquote>\n

\u3068\u8a00\u3044\u51fa\u3057\u305f\u308f\u3051\u3067\u3059\u3002\u201d\u3042\u308b\u201d\u201d\u5b58\u5728\u3059\u308b\u201d\u306f\u201d\u5f15\u304d\u7d99\u304c\u308c\u308b\u201d\u306e\u610f\u5473\u3067\u3042\u308b\u3068\u3044\u3046\u308f\u3051\u3067\u3059\u3002\u304a\u3063\u305f\u307e\u3052\u307e\u3059\u306d\u3002\u3082\u3057\u201d\u5f15\u304d\u7d99\u304c\u308c\u308b\u201d\u3068\u53d7\u3051\u53d6\u308c\u306a\u3044\u306e\u306a\u3089\u3001\u4e39\u7fbd\u6c0f\u304c\u66f8\u3044\u305f\u82f1\u6587\u3067\u3059\u304b\u3089\u4e39\u7fbd\u6c0f\u304c\u4f7f\u3063\u305f\u300care found\u300d\u304c\u9593\u9055\u3044\u3067\u3042\u308b\u3068\u8a00\u3046\u308f\u3051\u3067\u3059\u3002\u3059\u3054\u3044\u3067\u3059\u306d\u3002<\/p>\n

\u300cTS\u304c\u3001\u306e\u3061\u306e\u6a5f\u80fd\u3067\u3042\u308b\u304b\u3089\u3053\u305d\u3001are found\u3000\u304c\u767a\u898b\u306e\u610f\u5473\u306b\u306f\u306a\u308a\u307e\u305b\u3093\u3002\u300d<\/span>\u3000\u2190\u3000\u300c\u610f\u5473\u4e0d\u660e\u300d<\/span>\u3067\u3059\u3002\u300cTS\u304c\u3001\u306e\u3061\u306e\u6a5f\u80fd\u300d??TS\u3068\u306f\u306a\u3093\u3067\u3057\u3087\u306d\uff1f\u6a5f\u80fd\u306e\u4e00\u7a2e\u306a\u3093\u3067\u3059\u304b\u306d\uff1f<\/p>\n

\u305d\u3053\u3067\u6faa\u6a19\u3055\u3093\u304c\u3001\u5b66\u3068\u307f\u5b50\u306b\u52a9\u3051\u821f<\/a>\u3067\u3059\u3002\u82f1\u8a9enative\u306a\u65b9\u304c\u767a\u3059\u308b\u300cfind\u300d\u306f\u3001\u82f1\u548c\u8f9e\u5178\u3067\u306f\u308f\u304b\u3089\u306a\u3044\u3053\u3068\u304c\u3042\u308b\u304b\u3089\u82f1\u82f1\u8f9e\u5178\u3067\u8abf\u3079\u3066\u307f\u308b\u3079\u304d\u3067\u3042\u308b\u3068\u306e\u52a9\u8a00\u3067\u3059\u3002\u4e39\u7fbd\u6c0f\u304c\u82f1\u8a9enative\u304b\u3069\u3046\u304c\u308f\u304b\u308a\u307e\u305b\u3093\u304c\u3001\u82f1\u6587\u7dcf\u8aac\u3092\u57f7\u7b46\u3059\u308b\u304f\u3089\u3044\u3067\u3059\u304b\u3089\u82f1\u8a9e\u306b\u582a\u80fd\u306a\u65b9\u3067\u3042\u308b\u306e\u306f\u60f3\u50cf\u304c\u3064\u304d\u307e\u3059\u304b\u3089\u82f1\u82f1\u8f9e\u5178\u3067\u8abf\u3079\u308b\u3053\u3068\u306b\u610f\u7fa9\u304c\u3042\u308b\u3067\u3057\u3087\u3046\u3002\u6faa\u6a19\u3055\u3093\u306e\u63d0\u793a\u3057\u305f\u82f1\u82f1\u8f9e\u5178\u306efind\u306e\u9805<\/a>\u3092\u5b66\u3068\u307f\u5b50\u306f\u8aad\u3093\u3060\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n

\u3053\u306e\u82f1\u82f1\u8f9e\u5178\u306b\u306ffind\u306e\u610f\u5473\u3001\u7528\u4f8b\u3068\u3057\u3066\u6ca2\u5c71\u66f8\u3044\u3066\u3042\u308a\u307e\u3059\u304c\u3001\u300c\u898b\u3064\u304b\u3063\u305f\u3001\u898b\u3064\u3051\u305f\u3001\u8a8d\u8b58\u3059\u308b\u3001\u898b\u51fa\u3057\u305f\u3001\u767a\u898b\u3059\u308b\u3001\u6c17\u3065\u304f\u3001\u8abf\u3079\u308b\u300d\u3068\u3044\u3046\u3088\u3046\u306a\u65e5\u672c\u8a9e\u306b\u8a33\u3059\u306e\u304c\u3075\u3055\u308f\u3057\u3044\u4f8b\u3070\u304b\u308a\u3067\u3069\u3053\u306b\u3082\u3001\u524d\u5f8c\u95a2\u4fc2\u306e\u5b58\u5728\u304c\u5fc5\u9808\u306e\u201d\u5f15\u304d\u7d99\u304c\u308c\u308b\u201d\u306e\u3088\u3046\u306a\u610f\u5473\u306f\u898b\u3064\u3051\u3089\u308c\u307e\u305b\u3093\u3002\u5b66\u3068\u307f\u5b50\u306f\u6faa\u6a19\u3055\u3093\u306e\u89aa\u5207\u306a\u52a9\u8a00\u3092\u53d7\u3051\u5165\u308c\u305f\u3068\u306f\u601d\u3048\u307e\u305b\u3093\u3093\u306d\u3002<\/p>\n

\u5b66\u3068\u307f\u5b50\u66f0\u304f\uff1a\u300cevolutionarily conserved functions
\n\u3068\u3001\u540c\u4e00\u6587\u7ae0\u5185\u306b\u3001\u95a2\u9023\u8ee2\u5199\u56e0\u5b50\u306f\u3059\u3067\u306b\u904e\u53bb\u306b\u7372\u5f97\u3055\u308c\u305f\u6a5f\u80fd\u3067\u3042\u308b\u3068\u66f8\u304b\u308c\u3066\u3044\u308b\u3058\u3083\u306a\u3044\u3067\u3059\u304b\uff1f\u5f53\u6642\u306e\u305f\u3081\u606f\u3055\u3093\u306f\u539f\u6587\u3092\u8aad\u3093\u3067\u306a\u3044\u3093\u3067\u3059\u3088\u3002\u5168\u4f53\u628a\u63e1\u304c\u3001\u3067\u304d\u306a\u304b\u3063\u305f\u3093\u3067\u3059\u3002\u305d\u308c\u3067\u3082\u3001\u5b66\u3068\u307f\u5b50\u304c\u9593\u9055\u3063\u305f\u3068\u4fe1\u3058\u305f\u307e\u307e\u3001\u4eca\u3082\u305d\u3053\u3092\u4e3b\u5f35\u3057\u3066\u307e\u3059\u3002\u300d<\/span>\u3061\u304c\u3044\u307e\u3059\u306d\u3002\u5f53\u6642\uff082020\u5e7410\u6708\uff09\u3067\u3082\u9032\u5316\u306e\u9806\u304b\u3089\u3044\u3046\u3068\u53e4\u304f\u304b\u3089\u3042\u308b\u6a5f\u80fd\u306e\u610f\u5473\u3067\u3059<\/a>\u3068\u6b63\u3057\u304f\u7406\u89e3\u3057\u3066\u3044\u307e\u3059\u3002\u5b66\u3068\u307f\u5b50\u306f\u5f53\u65b9\u306e\u767a\u8a00\u3092\u8aad\u3080\u3053\u3068\u306a\u3057\u306b\u30c7\u30bf\u30e9\u30e1\u306a\u8a00\u3044\u304c\u304b\u308a\u3092\u4ed8\u3051\u3066\u3044\u308b\u306e\u3067\u3059\u3002<\/p>\n

\u5b66\u3068\u307f\u5b50\u66f0\u304f\uff1a\u300c\u305f\u3081\u606f\u3055\u3093\u3067\u3059\u3002
\n\uff1e<\/span>\uff08\u305f\u3081\u606f\u66f0\u304f\uff09\u7d2b\u306e\u90e8\u5206<\/span>\uff08\u4e0a\u8a18\u4e39\u7fbd\u6c0f\u306e\u82f1\u6587\u306e\u7d2b\u306e\u90e8\u5206\uff09\u306f\u300c\uff13\u3064\u306e\u8ee2\u5199\u56e0\u5b50\u304c\uff13\u3064\u306e\u7570\u306a\u308b\u90e8\u4f4d\u305d\u308c\u305e\u308c\u898b\u3064\u304b\u308b\u300d\u3068\u3042\u308b\u3060\u3051\u3067\u300c\u4e09\u80da\u8449\u5206\u5316\u306b\u95a2\u4fc2\u3057\u3066\u3044\u304f\u300d\u306a\u3069\u3068\u66f8\u3044\u3066\u3042\u308a\u307e\u305b\u3093\u3002<\/span><\/p>\n

\u300c\u4e09\u80da\u8449\u5206\u5316\u306b\u95a2\u4fc2\u3057\u3066\u3044\u304f\u300d\u3068\u3044\u3046\u7406\u89e3\u306f\u3001\u305f\u3081\u606f\u3055\u3093\u306e\u52dd\u624b\u306a\u308b\u8aa4\u8aad\u3067\u3059\u3002\u305d\u3093\u306a\u3053\u3068\u304c\u66f8\u304b\u308c\u3066\u3044\u308b\u308f\u3051\u7121\u3044\u3068\u3001\u305f\u3081\u606f\u3055\u3093\u306f\u601d\u308f\u306a\u3044\u3068\u3044\u3051\u307e\u305b\u3093\u3002\u3053\u306e\u9803\u306e\u305f\u3081\u606f\u3055\u3093\u306f\u308f\u304b\u3063\u3066\u3044\u306a\u3044\u3093\u3067\u3059\u3002\u8ee2\u5199\u56e0\u5b50\u306e\u7d44\u307f\u5408\u308f\u305b\u306e\u5999\u3067\u3001\u54fa\u4e73\u985e\u304c\u80ce\u76e4\u6a5f\u80fd\u3092\u7372\u5f97\u3067\u304d\u305f\u3068\u306e\u8ad6\u6587\u8ad6\u65e8\u304b\u3089\u3001\u305f\u3081\u606f\u3055\u3093\u306e\u982d\u304c\u96e2\u308c\u3066\u3044\u308b\u3093\u3067\u3059\u3002…\u5f53\u521d\u3001\u201d3\u3064\u306e\u8ee2\u5199\u56e0\u5b50\u304c\u3001\u4e09\u80da\u8449\u5206\u5316\u306b\u95a2\u4fc2\u3059\u308b\u201d\u3068\u3001\u5b66\u3068\u307f\u5b50\u304c\u66f8\u3044\u3066\u3044\u308b\u3068\u305f\u3081\u606f\u3055\u3093\u306f\u8aa4\u89e3\u3057\u305f\u306e\u3067\u3057\u3087\u3046\u3002\u300d<\/span>
\n\u300c\u300c\u4e09\u80da\u8449\u5206\u5316\u306b\u95a2\u4fc2\u3057\u3066\u3044\u304f\u300d\u3068\u3044\u3046\u7406\u89e3\u306f\u3001\u305f\u3081\u606f\u3055\u3093\u306e\u52dd\u624b\u306a\u308b\u8aa4\u8aad\u3067\u3059\u3002\u300d\u3068\u3044\u3046\u306e\u306f\u5f53\u65b9\u306e\u8aa4\u8aad\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u5b66\u3068\u307f\u5b50\u81ea\u8eab\u304c\u3057\u3063\u304b\u308a\u300cTS\u306b\u7279\u7570\u7684\u306a\u8ee2\u5199\u56e0\u5b50\u304c\u3001\u4e09\u80da\u8449\u5206\u5316\u306b\u95a2\u4fc2\u3057\u3066\u3044\u304f\u3068\u66f8\u3044\u3066\u3042\u308a\u307e\u3059\u3002\u300d<\/a>\u3068\u3067\u305f\u3089\u3081\u3092\u66f8\u3044\u305f\u306e\u3067\u3059\u3002\u4f55\u307c\u3051\u3066\u3044\u308b\u3093\u3067\u3057\u3087\u3046\u306d\uff1f<\/p>\n

\u300c\u305f\u3081\u606f\u3055\u3093\u306e\u7406\u89e3\u306f\u3001\u4eca\u306e\u72b6\u614b\u3068\u306f\u9055\u3063\u3066\u3044\u307e\u3057\u305f\u3088\u3002\u300d<\/span>\u3000\u2190\u3000\u3044\u3048\u30012010\u5e7410\u6708\u9803\u3068\u5168\u304f\u540c\u3058\u3067\u3059\u3002\u5b66\u3068\u307f\u5b50\u306e\u65b9\u304c\u5f53\u6642\u306e\u89e3\u91c8\u3068\u73fe\u5728\u3068\u9055\u3063\u3066\u304d\u3066\u3044\u308b\u306e\u3067\u306f\u306a\u3044\u3067\u3057\u3087\u3046\u304b\u3002\u5f53\u6642\u306f\u5168\u304f\u7406\u89e3\u3067\u304d\u3066\u3044\u306a\u304b\u3063\u305f\u306e\u304c\u3001\u5f53\u65b9\u7b49\u306e\u6307\u6458\u3067\u8003\u3048\u3092\u6539\u3081\u305f\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u601d\u308f\u308c\u307e\u3059\u3002<\/p>\n

\u300c\u8ee2\u5199\u56e0\u5b50\u306f\u7d44\u307f\u5408\u308f\u305b\u3066\u6a5f\u80fd\u3057\u3001\u305d\u306e\u6a5f\u80fd\u91cd\u8907\u3067TS\u306f\u9032\u5316\u3057\u305f\u3068\u304b\u306b\u3064\u3044\u3066\u3001\u4e39\u7fbd\u7dcf\u8aac\u306b\u66f8\u304b\u308c\u3066\u3044\u308b\u4e8b\u3092\u3001\u5f53\u6642\u306e\u305f\u3081\u606f\u306f\u308f\u304b\u3089\u306a\u304b\u3063\u305f\u307f\u305f\u3044\u3067\u3059\u3002\u300d<\/span>\u3000\u2190\u3000\u3053\u308c\u306f\u5618\u3067\u3059\u3002\u5f53\u6642\u304b\u3089\u4e39\u7fbd\u6c0f\u306e\u7dcf\u8aac\u3092\u6b63\u3057\u304f\u7406\u89e3\u3057\u3066\u3044\u308b\u30b3\u30e1\u30f3\u30c8<\/a>\u3092\u66f8\u3044\u3066\u3044\u307e\u3059\u3002\u5b66\u3068\u307f\u5b50\u306f\u4eca\u9803\u306b\u306a\u3063\u3066\u5f53\u65b9\u7b49\u306e\u6307\u6458\u3067\u3001\u4e09\u80da\u8449\u306b\u5b58\u5728\u3059\u308b\uff13\u3064\u8ee2\u5199\u56e0\u5b50\u304c\u6804\u990a\u819c\u3067\u3082\u4f7f\u308f\u308c\u308b\u3088\u3046\u306b\u306a\u3063\u305f\u3068\u3044\u3046\u3053\u3068\u304c\u7406\u89e3\u3067\u304d\u305f\u306e\u3067\u3057\u3087\u3046\u3002<\/p>\n

\u300c\u4e39\u7fbd\u7dcf\u8aac\u3092\u8aac\u660e\u3057\u3066\u3044\u308b\u5b66\u3068\u307f\u5b50\u304c\u305d\u3053\uff08\u4e09\u80da\u8449\u304b\u3089TS\u306b\u9032\u5316\u3057\u305f\uff09\u3092\u9593\u9055\u3046\u306f\u305a\u304c\u3042\u308a\u307e\u305b\u3093\u3002\u300d<\/span>\u2190\u3000\u3053\u308c\u3082\u5618\u3067\u3059\u3002\u5f53\u6642\u306f\u4e39\u7fbd\u6c0f\u306e\u82f1\u6587\u304c\u7406\u89e3\u3067\u304d\u3066\u3044\u306a\u304b\u3063\u305f\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002\u305d\u3046\u3067\u306a\u3044\u306e\u306a\u3089\u6b63\u3057\u3044\u65e5\u672c\u304c\u3067\u304d\u306a\u3044\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u306d\u3002<\/p>\n

\u300c\u5b66\u3068\u307f\u5b50\u306f\u3001\u5225\u306e\u3053\u3068\u3092\u8003\u3048\u3066\u3001\u201d\u5f15\u304d\u7d99\u304c\u308c\u308b\u201d\u3092\u4f7f\u3063\u3066\u3044\u307e\u3057\u305f\u3002
\n\u5f53\u6642\u3001\u5b66\u3068\u307f\u5b50\u306f\u3001\u80da\u306e\u767a\u751f\u7d4c\u7def\u3092\u30a4\u30e1\u30fc\u30b8\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u80da\u306f\u767a\u751f\u5f8c\u3001\u8ee2\u5199\u56e0\u5b50\u3092\u5171\u6709\u3057\u3066\u5206\u5316\u3057\u3066\u3044\u304d\u307e\u3059\u3002
\n\u80da\u5206\u5272\u304c\u9032\u307f\u3001\u5185\u90e8\u7d30\u80de\u584a\uff08ES\u306e\u5143\uff09\u3001\u6804\u990a\u5916\u80da\u8449\uff08TS\u306e\u5143\uff09\u3068\u5206\u5316\u304c\u9032\u3080\u6642\u3001TS\u3067\u8a3c\u660e\u3055\u308c\u305f\u8ee2\u5199\u56e0\u5b50\u306f\u307e\u305f\u3001\u6d3b\u8e8d\u3059\u308b\u306e\u3067\u3059\u3002
\n\u3053\u306e\u73fe\u8c61\u3092\u3082\u3063\u3066\u201d\u5f15\u304d\u7d99\u304c\u308c\u308b\u201d\u3068\u306e\u65e5\u672c\u8a9e\u8868\u73fe\u3057\u3066\u3001\u4f55\u304c\u3044\u3051\u306a\u3044\u306e\u3067\u3057\u3087\u3046\u304b\uff1f\u300d<\/p><\/blockquote>\n

\u307e\u3060\u7406\u89e3\u3067\u304d\u3066\u3044\u306a\u3044\u306e\u304b\u3001\u65e5\u672c\u8a9e\u3067\u6b63\u3057\u304f\u8868\u73fe\u3067\u304d\u306a\u3044\u306e\u304b\u3001\u3069\u3063\u3061\u304b\u3067\u3059\u306d\u3002\u300cTS\u3067\u8a3c\u660e\u3055\u308c\u305f\u8ee2\u5199\u56e0\u5b50\u306f\u307e\u305f\u3001\u6d3b\u8e8d\u3059\u308b\u300d\uff1f\u4f55\u3092\u8a00\u3063\u3066\u3044\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f\u4e39\u7fbd\u6c0f\u306f\u300c\u5185\u90e8\u7d30\u80de\u584a\uff08\u4e09\u80da\u8449\u306b\u5206\u5316\u3059\u308b\uff09\u3067\u8a3c\u660e\u3055\u308c\u305f\u8ee2\u5199\u56e0\u5b50\u306f\u3001\u307e\u305fTS\u3067\u6d3b\u8e8d\u3059\u308b\u300d\u3068\u66f8\u3044\u3066\u3044\u308b\u306e\u3067\u3059\u3002\u9006\u306a\u306e\u3067\u3059\u3002\u30db\u30f3\u30c8\u99ac\u9e7f\u3067\u3059\u306a\u3002<\/p>\n

\u300c\u305f\u3081\u606f\u30d6\u30ed\u30b0\u306f\u3001\u201d\u5f15\u304d\u7d99\u3050\u201d\u3068\u306f\u3001TS\u304b\u3089\u4e09\u80da\u8449\u3078\u9032\u5316\u3057\u3066\u3044\u304f\u306e\u30a4\u30e1\u30fc\u30b8\u3057\u304b\u6d6e\u304b\u3070\u306a\u3044\u306e\u3067\u3059\u3002\u300d<\/span>\u3000\u2190\u3000\u305d\u3093\u306a\u3053\u3068\u3092\u30a4\u30e1\u30fc\u30b8\u3059\u308b\u308f\u3051\u304c\u306a\u3044\u3067\u3057\u3087\u3046\u304c\u3002\u5b66\u3068\u307f\u5b50\u304c\u3001\u4e0a\u306b\u3042\u308b\u3088\u3046\u306b\u300cTS\u306b\u4fdd\u5b58\u3055\u308c\u305f\u8ee2\u5199\u56e0\u5b50\u304c\u3001\u305d\u306e\u5f8c\u306e\u5185\u3001\u4e2d\u3001\u5916\u306e\uff13\u80da\u8449\u7cfb\u306e\u7d30\u80de\u5206\u5316\u3001\u306b\u5f15\u304d\u7d99\u304c\u308c\u3066\u3044\u308b\u300d<\/span>\u3068\u66f8\u3044\u305f\u306e\u3067\u3057\u3087\u3046\u304c\u3002<\/p>\n

\u3084\u3063\u3071\u308a\u6faa\u6a19\u3055\u3093\u306e\u201d\u7d20\u4eba\u3055\u3093\u201d\u3084\u3001\u539f\u6587\u3092\u8aad\u307e\u306a\u3044\u3068\u601d\u308f\u308c\u308b\u201d\u5c02\u9580\u5bb6\u201d\u306b\u3001\u201d\u8aa4\u8aad\u201d\u3055\u308c\u308b\u3053\u3068\u304c\u3001\u4e07\u304c\u4e00\u306b\u3082\u306a\u3044\u3088\u3046\u59d4\u66f2\u3092\u5c3d\u304f\u3059\u306e\u304c\u7d39\u4ecb\u8005\u306e\u8cac\u52d9\u3068\u5b58\u3058\u307e\u3059\u3002<\/a>\u3068\u3044\u3046\u52a9\u8a00\u306f\u300c\u6faa\u6a19\u3055\u3093\u3001\u4ee5\u4e0b\u306f\u3042\u308a\u304c\u305f\u3044\u3054\u5fe0\u544a\u3067\u3059\u304c\u3001\u304a\u4e92\u3044\u306b\u8aa0\u610f\u3092\u3082\u3063\u3066\u3084\u308a\u3068\u308a\u3059\u308b\u4eba\u305f\u3061\u3067\u901a\u7528\u3059\u308b\u30eb\u30fc\u30eb\u3067\u3059\u3002\u300d<\/span>\u3068\u7406\u7531\u306b\u3082\u306a\u3089\u306a\u3044\u8a00\u3044\u8a33\u3067\u62d2\u5426\u3055\u308c\u307e\u3057\u305f\u3002\u6faa\u6a19\u3055\u3093\u306e\u30b3\u30e1\u30f3\u30c8\u306f\u5f53\u65b9\u306b\u5bfe\u3059\u308b\u614b\u5ea6\u3067\u306f\u306a\u304f\u3001\u4e00\u822c\u8ad6\u3068\u3057\u3066\u3001”\u79d1\u5b66\u304c\u308f\u304b\u3063\u3066\u3044\u308b\u5b66\u3068\u307f\u5b50”\u306a\u3089\u8aa4\u8aad\u3055\u308c\u306a\u3044\u3088\u3046\u306b\u6b63\u3057\u3044\u65e5\u672c\u8a9e\u3067\u89e3\u8aac\u3059\u3079\u304d\u3067\u3042\u308b\u3068\u3044\u3063\u3066\u3044\u308b\u306e\u304c\u308f\u304b\u3089\u306a\u3044\u308f\u3051\u3067\u3059\u306d\u3002\u76ae\u8089\u3067\u3059\u3051\u3069\u306d\u3002<\/p>\n

Among the TFs of the TSC-specific network, the evolutionarily conserved functions \u306b\u3064\u3044\u3066\u3002<\/p>\n

\u5b66\u3068\u307f\u5b50\u306fAmong\u3068conserved\u3092\u8aa4\u3063\u3066\u89e3\u91c8\u3057\u3001\u300cTS\u306b\u4fdd\u5b58\u3055\u308c\u305f\u8ee2\u5199\u56e0\u5b50Sox2, Eomes Cdx2\u300d\u3068\u3057\u3066\u3057\u307e\u3063\u305f\u308f\u3051\u3067\u3059\u3002\u4e39\u7fbd\u6c0f\u306e\u3053\u306e\u82f1\u6587\u306e\u610f\u5473\u306f\u3001\u300c\u6570\u591a\u304f\u3042\u308b\u8ee2\u5199\u56e0\u5b50\u306e\u5185\uff08among\uff09\u3067\u3001\u9032\u5316\u7684\u306b\u53e4\u304f\u304b\u3089\u3042\u308b\uff08conserved\uff09\uff13\u3064\u306e\u8ee2\u5199\u56e0\u5b50\u306f\u4e09\u80da\u8449\u306b\u5b58\u5728\u3059\u308b\uff08are found\uff09\u304c\uff08but\uff09…\u300d\u3068\u3044\u3046\u3053\u3068\u306a\u306e\u3067\u3059\u3002among \u3092\u65e5\u672c\u8a9e\u3067\u300c\u4e2d\u306b\u300d\u3068\u8a33\u3057\u3001\u305d\u306e\u65e5\u672c\u8a9e\u306e\u300c\u4e2d\u300d\u306b\u3068\u3089\u308f\u308c\u3066\u300cTS\u306e\u5185\u90e8\u306b\u3042\u308b\u300d\u3068\u3057\u3066\u3057\u307e\u3063\u305f\u308f\u3051\u3067\u3059\u3002among \u306f\u8907\u6570\u3042\u308b\u3046\u3061\u304b\u3089\uff11\u3064\u3001\uff12\u3064..\u3068\u3044\u3046\u610f\u5473\u3067\u3001\u300c\u4e2d\u304b\u3089\u300d\u3068\u8a33\u3057\u3066\u3044\u3044\u306e\u3067\u3059\u304c\u3001\u3053\u306e\u65e5\u672c\u8a9e\u8a33\u306e\u300c\u4e2d\u300d\u3092\u300c\u5185\u90e8\u300d\u3068\u89e3\u91c8\u3057\u3066\u306f\u3044\u3051\u306a\u3044\u306e\u3067\u3059\u3002<\/p>\n

\u307e\u305fconserve\u3092\u4fdd\u5b58\u3068\u89e3\u91c8\u3057\u305f\u308f\u3051\u3067\u3059\u306d\u3002\u305f\u3057\u304b\u306bconserve\u306f\u4fdd\u5b58\u3067\u3059\u304c\u3001\u3053\u306e\u5834\u5408\u306f\u300cTS\u306b\u4fdd\u5b58\u3055\u308c\u3066\u3044\u308b\u300d\u3068\u3044\u3046\u306e\u3067\u306f\u306a\u304f\u300cevolutionarily conserved\u300d\u3068\u3042\u308b\u306e\u3067\u3059\u304b\u3089\u300c\u9032\u5316\u7684\u306b\u53e4\u304f\u304b\u3089\u3042\u308b\/\u4f7f\u308f\u308c\u3066\u3044\u308b\u300d\u3068\u3044\u3046\u610f\u5473\u3067\u3059\u306d\u3002conserve\u306f\u4fdd\u5b58\u3067\u3059\u304c\u3001\u5909\u5316\u3057\u3066\u3044\u306a\u3044\u3001\u4fdd\u3064\u3068\u3044\u3046\u3088\u3046\u306a\u610f\u5473\u3067\u3059\u304b\u3089\u306d\u3002<\/p>\n

\u300cTS\u306b\u4fdd\u5b58\u3055\u308c\u305f\uff13\u3064\u306e\u8ee2\u5199\u56e0\u5b50\u304c\u4e09\u80da\u8449\u306b\u5f15\u304d\u7d99\u304c\u308c\u308b\u300d\u3068\u8aa4\u3063\u3066\u89e3\u91c8\u3057\u305f\u7406\u7531\u306e\uff11\u3064\u304c\u3001\u3053\u306eamong\u3068conserve\u306e\u610f\u5473\u304c\u308f\u304b\u3089\u306a\u304b\u3063\u305f\u3053\u3068\u306b\u3042\u308a\u307e\u3059\u3002\u4eca\u3067\u306f\u3053\u306e\u8868\u73fe\u306f\u9593\u9055\u3044\u3067\u9006\u3067\u3042\u308b\u3068\u601d\u3063\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u304c\u3001\u610f\u5730\u3067\u3082\u3053\u306e\u6587\u7ae0\u304c\u8aa4\u308a\u3067\u306f\u306a\u3044\u3068\u4e3b\u5f35\u3059\u308b\u305f\u3081\u306bare found \u3092\u5f15\u304d\u7d99\u3050\u306a\u3069\u3068\u30c7\u30bf\u30e9\u30e1\u306a\u89e3\u91c8\u3092\u5f8c\u4ed8\u3057\u3066\u3044\u308b\u308f\u3051\u3067\u3059\u306d\u3002<\/p>\n

\u3061\u306a\u307f\u306b\u6faa\u6a19\u3055\u3093\u3054\u7d39\u4ecb\u306eAmerican Heritage \u3067\u306f among \u3092\u4f7f\u3063\u305f\u4f8b\u6587\u3068\u3057\u3066\u3001\uff11\uff0e\u6749\u306e\u6728\u306e\u7fa4\u306e\u4e2d\u306e\u677e\u306e\u6728\u3001\uff12\uff0e\u30b0\u30eb\u30fc\u30d7\u306e\u4e2d\u3067\u88d5\u798f\u306a\u4e00\u4eba\u3001\uff13\uff0e\u65c5\u884c\u8005\u30b0\u30eb\u30fc\u30d7\u306e\u4e2d\u3067\u3001\uff14\uff0e\u30ae\u30ea\u30b7\u30e3\u4eba\u306e\u4e2d\u3067\u3001\uff15\uff0e\u6211\u3005\u306e\u9593\u3067\u3001\uff16\uff0e\u3042\u306a\u305f\u305f\u3061\u306b\u3001\uff17\uff0e\u81ea\u5206\u305f\u3061\u306e\u9593\u3067\u3000\u306a\u3069\u304c\u66f8\u3044\u3066\u3042\u308a\u307e\u3059\u3002\u5185\u90e8\u3068\u3044\u3046\u3053\u3068\u3067\u4f7f\u308f\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n

\u3064\u307e\u308a\u4e39\u7fbd\u6c0f\u306e\u82f1\u6587\u3092\u300c\u9032\u5316\u7684\u306b\u53e4\u3044\uff13\u3064\u306e\u8ee2\u5199\u56e0\u5b50\u306f\u4e09\u80da\u8449\u306b\u5b58\u5728\u3059\u308b\u304c\u3001\u9032\u5316\u7684\u306b\u65b0\u3057\u3044\u7d44\u7e54\u3067\u3042\u308b\u6804\u990a\u819c\u3067\u306f\u3053\u306e\uff13\u3064\u306e\u8ee2\u5199\u56e0\u5b50\u304c\u5354\u50cd\u3057\u3066\u3044\u308b\u300d\u3068\u8a33\u305b\u3070\u5168\u304f\u554f\u984c\u306a\u3044\u306e\u3067\u3059\u3002\u3053\u308c\u3092\u5185\u90e8\u306b\u4fdd\u5b58\u3068\u304b\u5f15\u304d\u7d99\u3050\u306a\u3069\u3068\u3001\u504f\u898b\u3067\u89e3\u91c8\u3057\u3066\u3001\u5e73\u6c17\u3067\u65e5\u672c\u8a9e\u306b\u3057\u3066\u66f8\u3044\u305f\u306e\u304c\u9593\u9055\u3044\u3067\u3057\u305f\u3002<\/p>\n

\u5b66\u3068\u307f\u5b50\u306f\u3001\u7d76\u5bfe\u300c\u5f15\u304d\u7d99\u3050\u300d\u3092\u8a02\u6b63\u3057\u306a\u3044\u3067\u3057\u3087\u3046\u306d\u3002\uff11\u5e74\u524d\u3082\u6b63\u3057\u304f\u8aad\u307f\u3001\u6b63\u3057\u304f\u66f8\u3044\u305f\u3068\u8a00\u3046\u3067\u3057\u3087\u3046\u306d\u3002\u6b63\u3057\u304f\u8aad\u3093\u3060\u304c\u6b63\u3057\u304f\u66f8\u3051\u306a\u304b\u3063\u305f\u3001\u7406\u89e3\u3067\u304d\u305a\u306b\u66f8\u3044\u305f\u3000\u3069\u3063\u3061\u304b\u3068\u3044\u3048\u3070\u3001\u65e5\u672c\u3067\u306e\u6700\u9ad8\u306e\u6559\u80b2\u3092\u53d7\u3051\u305f\u535a\u58eb\u304c\u6b63\u3057\u3044\u65e5\u672c\u8a9e\u304c\u3067\u304d\u306a\u3044\u3068\u3059\u308b\u3088\u308a\u3001\u82f1\u8a9enative\u3067\u306a\u3044\u306e\u3067\u6b63\u3057\u304f\u7406\u89e3\u3067\u304d\u306a\u304b\u3063\u305f\u3068\u3059\u308b\u306e\u304c\u81ea\u7136\u3067\u3059\u304c\u3001\u3053\u308c\u307e\u3067\u5f53\u65b9\u3092\u542b\u3081\u305f\u8907\u6570\u306e\u65b9\u3005\u304b\u3089\u300c\u610f\u5473\u4e0d\u660e\u300d\u3068\u3044\u3046\u8d64\u3044\u30b9\u30bf\u30f3\u30d7\u3092\u62bc\u3055\u308c\u3066\u304d\u305f\u3053\u3068\u3092\u8003\u3048\u308b\u3068\u3001\u4e21\u65b9\u3067\u3057\u3087\u3046\u306d\u3002<\/p>\n

\u307e\u305f\u300can evolutionarily new cell type, the trophoblast. \u300d\u3092\u8d64\u5b57\u306b\u3057\u3066\u91cd\u8981\u3060\u3068\u3044\u3063\u3066\u3044\u307e\u3059\u304c\u3001\u3053\u308c\u3082\u5b66\u3068\u307f\u5b50\u304c\u4e39\u7fbd\u6c0f\u7dcf\u8aac\u3092\u7406\u89e3\u3067\u304d\u3066\u3044\u306a\u3044\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u300cthey cooperate together\u300d\u306e\u307b\u3046\u304c\u4e39\u7fbd\u6c0f\u7dcf\u8aac\u3067\u610f\u5473\u306e\u3042\u308b\u3053\u3068\u3067\u3001trophoblast\u304c\u9032\u5316\u7684\u306b\u65b0\u3057\u3044\u7d30\u80de\u3067\u3042\u308b\u3053\u3068\u306f\u4e39\u7fbd\u6c0f\u304c\u65b0\u305f\u306b\u8a00\u3046\u307e\u3067\u3082\u306a\u3044\u3053\u3068\u3067\u3059\u304b\u3089\u306d\u3002<\/p>\n

\u306f\u3044\u3001\u3053\u306e\u5f53\u65b9\u306e\u610f\u898b\u306b\u5bfe\u3059\u308b\u53cd\u5fdc\u306f\u3001\u3082\u3057\u3042\u3063\u305f\u3089\u300c\u304a\u524d\u306e\u30ab\u30fc\u30c1\u30e3\u30f3\u51fa\u3079\u305d\u300d\u7684\u767a\u8a00\u3067\u3001\u6c7a\u3057\u3066\u500b\u3005\u306b\u3064\u3044\u3066\u5177\u4f53\u7684\u306b\u53cd\u8ad6\u3059\u308b\u3053\u3068\u306f\u306a\u3044\u3067\u3057\u3087\u3046\u3002\u3059\u3067\u306b\u65b0\u3057\u3044\u3001\u8ee2\u8f09\u3070\u304b\u308a\u306e\u8a18\u4e8b<\/a>\u3082\u66f8\u3044\u305f\u3053\u3068\u3060\u3057\u3001\u7121\u8996\u3059\u308b\u53ef\u80fd\u6027\u3082\u3042\u308a\u307e\u3059\u306d\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u5b66\u3068\u307f\u5b50\u306e\u30d6\u30ed\u30b0\u306b\u66f8\u3044\u3066\u3042\u308b\u30c7\u30bf\u30e9\u30e1\u3001\u7279\u306b\u82f1\u8a9e\u8ad6\u6587\u7d39\u4ecb\u306e\u30c7\u30bf\u30e9\u30e1\u306e\u539f\u56e0\u306f \u2460\u6b63\u3057\u3044\u65e5\u672c\u8a9e\u306e\u8868\u73fe\u304c\u3067\u304d\u306a\u3044 \u2461\u82f1\u8a9e\u3092\u307e\u3068\u3082\u306b\u7406\u89e3\u3067\u304d\u306a\u3044 \u306e\u3069\u3061\u3089\u304b\u3001\u3042\u308b\u3044\u306f\u4e21\u65b9\u304b\u3068\u601d\u308f\u308c\u307e\u3059\u3002 \u2460\u306e\u6b63\u3057\u3044\u65e5\u672c\u8a9e\u304c\u4f7f\u3048\u306a\u3044\u3068\u3044\u3046\u306e\u306f\u3001\u56fd\u5185 … \u7d9a\u304d\u3092\u8aad\u3080 are found …<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2,8],"tags":[],"class_list":["post-19319","post","type-post","status-publish","format-standard","hentry","category-education","category-fake"],"_links":{"self":[{"href":"https:\/\/nbsigh2.com\/index.php?rest_route=\/wp\/v2\/posts\/19319","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nbsigh2.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nbsigh2.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nbsigh2.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nbsigh2.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=19319"}],"version-history":[{"count":36,"href":"https:\/\/nbsigh2.com\/index.php?rest_route=\/wp\/v2\/posts\/19319\/revisions"}],"predecessor-version":[{"id":25472,"href":"https:\/\/nbsigh2.com\/index.php?rest_route=\/wp\/v2\/posts\/19319\/revisions\/25472"}],"wp:attachment":[{"href":"https:\/\/nbsigh2.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=19319"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nbsigh2.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=19319"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nbsigh2.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=19319"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}