{"id":18215,"date":"2021-02-11T10:49:29","date_gmt":"2021-02-11T01:49:29","guid":{"rendered":"http:\/\/seigi.accsnet.ne.jp\/sigh\/blog\/?p=18215"},"modified":"2021-02-11T10:49:29","modified_gmt":"2021-02-11T01:49:29","slug":"%e6%b3%a8%e5%b0%84%e5%99%a8%e3%81%ae%e3%83%87%e3%83%83%e3%83%89%e3%82%b9%e3%83%9a%e3%83%bc%e3%82%b9","status":"publish","type":"post","link":"https:\/\/nbsigh2.com\/?p=18215","title":{"rendered":"\u6ce8\u5c04\u5668\u306e\u30c7\u30c3\u30c9\u30b9\u30da\u30fc\u30b9"},"content":{"rendered":"

\t\t\t\t\u901a\u5e38\u4f7f\u3046disposable syringe \uff08\u4f7f\u3044\u6368\u3066\u6ce8\u5c04\u5668\uff09\u306e dead space \u304c\u5927\u304d\u304f\u3066\u3001COVID-19\u306e\u30ef\u30af\u30c1\u30f3\u304c\uff16\u540d\u5206\u306a\u306e\u306b\uff15\u540d\u5206\u3057\u304b\u6295\u4e0e\u3067\u304d\u306a\u3044\u3068\u554f\u984c<\/a>\u306b\u306a\u3063\u3066\u3044\u308b\u3002<\/p>\n

\u4ee5\u4e0b\u306b\u66f8\u3044\u305f\u306e\u306f\u8584\u3081\u3066\u6295\u4e0e\u3059\u308c\u3070\u3044\u3044\u3068\u3044\u3046\u7d20\u4eba\u8003\u3048\u3067\u3042\u308b\u3002<\/p>\n

\uff11\u30d0\u30a4\u30a2\u30eb\u74f6\u306b0.45 ml \u306e\u30ef\u30af\u30c1\u30f3\u6eb6\u6db2\u304c\u5165\u3063\u3066\u3044\u3066\u3001\u3053\u308c\u306b1.8 ml \u306e\u751f\u7406\u98df\u5869\u6c34\u3092\u52a0\u3048\u3001\u5408\u8a08 2.25 ml \u306b\u8abf\u6574\u3057\u30010.3 ml\/\u56de\u3000\u3067\uff16\u56de\u6295\u4e0e\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u6ce8\u5c04\u5668\u306e\u30c7\u30c3\u30c9\u30b9\u30da\u30fc\u30b9\u304c 2.25-(0.3*6)=0.45 ml \u3053\u308c\u3092\uff16\u56de\u3067\u5272\u308b\u30680.075 ml\u3067\u306a\u3044\u3068\u307e\u305a\u3044\u3001\u3068\u3044\u3046\u304b\u30c7\u30c3\u30c9\u30b9\u30da\u30fc\u30b9\u304c0.075 ml\u306e\u6ce8\u5c04\u5668\u3092\u4f7f\u3046\u3053\u3068\u3092\u524d\u63d0\u306b\u30ef\u30af\u30c1\u30f3\u306e\u91cf\u3068\u5e0c\u91c8\u751f\u7406\u98df\u5869\u6c34\u306e\u91cf\u304c\u6c7a\u5b9a\u3055\u308c\u3066\u3044\u305f\u308f\u3051\u3060\u3002\u30c7\u30c3\u30c9\u30b9\u30da\u30fc\u30b9\u304c 0.15 ml \u306e\u666e\u53ca\u3057\u3066\u3044\u308b\u30c7\u30a3\u30b9\u30dd\u6ce8\u5c04\u5668\u3067\u306f\uff11\u56de\u306b\u4f7f\u3046\u91cf\u304c\u3000\u6ce8\u5165\u91cf0.3 ml+ \u30c7\u30c3\u30c9\u30b9\u30da\u30fc\u30b9\u91cf0.15 ml = 0.45 ml\u5fc5\u8981\u3067\u3001\u30d0\u30a4\u30a2\u30eb\u74f6\u306b\u306f2.25 ml \u306a\u306e\u306722.5 \/ 0.45 = 5 \u56de \u3068\u3044\u3046\u3053\u3068\u306b\u306a\u3063\u3066\uff15\u56de\u5206\u3057\u304b\u3067\u304d\u306a\u3044\u3068\u3044\u3046\u308f\u3051\u3060\u3002<\/p>\n

\u5f53\u65b9\u306e\u3088\u3046\u306a\u723a\u306e\u5c0f\u5b66\u751f\u3053\u308d\u306e\u4e88\u9632\u6ce8\u5c04\u306f\u6ce8\u5c04\u5668\u3068\u6ce8\u5c04\u91dd\u3092\u4f7f\u3044\u56de\u3057\u3066\u3044\u305f\u3001\u3064\u307e\u308a\u6ce8\u5c04\u5668\u306b\u3044\u3063\u3071\u3044\u6ce8\u5165\u6db2\u3092\u5165\u308c\u3066\u3001\u3053\u308c\u3067\u4f55\u4eba\u3082\u306e\u5b50\u4f9b\u306b\u5c11\u3057\u3065\u3064\u6ce8\u5165\u3057\u3066\u3044\u305f\u306e\u3060\u3002\u4eca\u304b\u3089\u8003\u3048\u3048\u308b\u3068\u3072\u3069\u3044\u3082\u3093\u3067\u3001\u6700\u521d\u3001\u6ce8\u5c04\u5668\u3068\u6ce8\u5c04\u91dd\u306f\u716e\u6cb8\u6d88\u6bd2\u3059\u308b\u306e\u3060\u304c\u3001\u6ce8\u5c04\u91dd\u3092\u4f7f\u3044\u56de\u3059\u308f\u3051\u3067\u3001\u611f\u67d3\u8005\u306b\u523a\u3057\u305f\u91dd\u3092\u5065\u5e38\u8005\u306b\u523a\u3059\u306e\u3067B\u578b\u809d\u708e\u30a6\u30a4\u30eb\u30b9\u306b\u611f\u67d3\u3057\u305f\u308a\u3057\u305f\u308f\u3051\u3067\u3059\u306a\u3002\u3053\u306e\u3068\u304d\u306f\u6ce8\u5c04\u5668\u306e\u30c7\u30c3\u30c9\u30b9\u30da\u30fc\u30b9\u306a\u3069\u554f\u984c\u306b\u306a\u3089\u306a\u3044\u308f\u3051\u3060\u304c\u3001\u73fe\u5728\u3067\u306f\u8a31\u3055\u308c\u306a\u3044\u306e\u3060\u3001\u5f53\u6642\u306f\u4f7f\u3044\u6368\u3066\u306e\u6ce8\u5c04\u5668\u3001\u6ce8\u5c04\u91dd\u306a\u3069\u306a\u304b\u3063\u305f\u304b\u3089\u306a\u3002<\/p>\n

\u30ef\u30af\u30c1\u30f3\u306e\u6210\u5206\u3067\u3042\u308bmRNA\u306e\u91cf\u306f\u3069\u3046\u3084\u3063\u3066\u8868\u73fe\u3057\u3066\u3044\u3044\u306e\u304b\u308f\u304b\u3089\u306a\u3044\u306e\u3067\u3001\u4e00\u56de\u306e\u6295\u4e0e0.3 ml\u306b\u6709\u52b9\u6210\u5206\u304c\uff11\u5358\u4f4d\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u306b\u3059\u308b\uff0830 \u03bcg \u3089\u3057\u3044\uff09\u3002
\n0.45 ml \u306e\u539f\u6db2\u306b1.8 ml \u306e\u751f\u7406\u98df\u5869\u6c34\u3092\u52a0\u3048\u30012.25 ml \u306b\u3059\u308b\u308f\u3051\u3060\u30020.3 ml*6 shot=1.8 ml \u304c\u6295\u4e0e\u3055\u308c\u6b8b\u308a\u306e 0.45 ml \u304c\u30c7\u30c3\u30c9\u30b9\u30da\u30fc\u30b9\uff080.075 ml \/ \u56de\uff09\u5206\u306a\u308f\u3051\u3060\u30022.25 ml \u306b\u306f\u30006 \u5358\u4f4d\uff0a2.25 ml \/ 1.8 ml = 7.5 \u5358\u4f4d\u3000\u542b\u307e\u308c\u3066\u3044\u308b\u308f\u3051\u3060\u3002\u5e0c\u91c8\u524d\u306e\u539f\u6db2\u30000.45 ml \u306b\u30827.5 \u5358\u4f4d\u542b\u307e\u308c\u3066\u3044\u308b\u308f\u3051\u3060\u3002<\/p>\n

\u4eca\u3001\u30c7\u30c3\u30c9\u30b9\u30da\u30fc\u30b9\u306b\u6b8b\u3063\u3066\u3057\u307e\u3046\u306e\u304c\u554f\u984c\u306a\u3093\u3060\u304b\u3089\u3001\u305d\u3057\u3066\u30c7\u30c3\u30c9\u30b9\u30da\u30fc\u30b9\u3092\u5909\u66f4\u3067\u304d\u306a\u3044\u306e\u3060\u304b\u3089\u3001\u30c7\u30c3\u30c9\u30b9\u30da\u30fc\u30b9\u306b\u6b8b\u308b\u6709\u52b9\u6210\u5206\u3092\u5c11\u306a\u304f\u3059\u308b\u3053\u3068\u306b\u3059\u308b\u305f\u3081\u306b\u306f\u6eb6\u6db2\u306e\u6fc3\u5ea6\u3092\u8584\u304f\u3057\u3001\u6295\u4e0e\u5bb9\u91cf\u3092\u5927\u304d\u304f\u3059\u308c\u3070\u3044\u3044\u3002<\/p>\n

\u672c\u6765\u306f 1.8 ml \u306e\u751f\u7406\u98df\u5869\u6c34\u3092\u52a0\u3048\u308b\u306e\u3092\u3001\uff15\u500d\u306e 9 ml\u52a0\u3048\u308b\u3053\u3068\u306b\u3059\u308b\u3002
\n7.5 \u5358\u4f4d \/ (0.45 + 9) ml = 7.5 \u5358\u4f4d \/ 9.45 ml \u304c\u6ce8\u5165\u6db2\u306e\u6fc3\u5ea6\u306b\u306a\u308b\u3002
\n\u3053\u306e\u5bb9\u91cf\u304b\u3089\uff16\u56de\u6295\u4e0e\u3067\u304d\u308b\u91cf x ml\u306f\u3001\u30c7\u30c3\u30c9\u30b9\u30da\u30fc\u30b9\u304c 0.15 ml \u3060\u304b\u3089
\n9.45 ml \/ (x + 0.15)ml = 6 \u56de\u3000\u3067\u3000\uff58 = 1.425 ml \u3068\u306a\u308b\u3002\u6295\u4e0e\u91cf\u306f1.425 ml \u306b\u3059\u308b\u306e\u3060\u3002\u3053\u306e1.425 ml \u306b\u306f RNA \u304c\u30001.425 ml * 7.5 \u5358\u4f4d \/ 9.45 ml = 1.131 \u5358\u4f4d\u542b\u307e\u308c\u308b\u3002\u6ce8\u5165\u91cf\u30001.425 ml * 6\u56de\uff1d8.55 ml\u3001\u30c7\u30c3\u30c9\u30b9\u30da\u30fc\u30b9\u5206 0.15 ml* 6\u56de\uff1d 0.9 ml\u3001\u5408\u8a089.45 ml \u3068\u306a\u308b\u3002<\/p>\n

\u7b4b\u5185\u6ce8\u5c04\u306e\u91cf\u306f\u3069\u306e\u4f4d\u8a31\u3055\u308c\u308b\u304b\u3060\u304c\u6570 \uff4d\uff4c<\/a>\u3068\u304b5 ml<\/a>\u3068\u304b\u306e\u8a18\u8ff0\u304c\u3042\u308b\u304b\u30891.5 ml\u306f\u554f\u984c\u306a\u3055\u305d\u3046\u3060\u3002\u6295\u4e0e\u7269\u8cea\u306f\u6fc3\u5ea6\u304c\u8584\u3044\u3068\u52b9\u679c\u304c\u4e0b\u304c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u8102\u8cea\u819c\u306b\u56f2\u307e\u308c\u305fRNA\u304c\u6fc3\u5ea6\u304c\u8584\u304f\u306a\u3063\u305f\u3068\u304d\u3069\u3046\u306a\u308b\u304b\u308f\u304b\u3089\u306a\u3044\u3002\u6fc3\u5ea6\u304c\u8584\u304f\u306a\u308b\u3068\u58ca\u308c\u308b\u901f\u5ea6\u304c\u9ad8\u304f\u306a\u308b\u304a\u305d\u308c\u304c\u3042\u308b\u3002
\n\u6ce8\u5165\u91cf\u306e\u3001\u672c\u6765\u306e0.3 ml \u304c 1.5 ml(\u8a08\u7b97\u3067\u306f1.425 ml)\u3068\uff15\u500d\u306b\u306a\u3063\u305f\u3068\u304d\u52b9\u679c\u306f\u3069\u3046\u306a\u308b\u304b\u308f\u304b\u3089\u306a\u3044\u3002\u8584\u304f\u306a\u3063\u305f\u306e\u3067\u3001mRNA \u304c\u7d30\u80de\u306b\u53d6\u308a\u8fbc\u307e\u308c\u308b\u91cf\u304c\u6e1b\u308a\u3001\u4f5c\u3089\u308c\u308b\u6297\u539f\u3068\u306a\u308b\u30b9\u30d1\u30a4\u30af\u86cb\u767d\u306e\u91cf\u304c\u6e1b\u308a\u3001\u3057\u305f\u304c\u3063\u3066\u6297\u4f53\u306e\u4f5c\u6210\u91cf\u304c\u6e1b\u308b\u3053\u3068\u304c\u8003\u3048\u3089\u308c\u308b\u304c\u3001\u307b\u304b\u306e\u8981\u7d20\u3082\u3042\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3002\u6fc3\u5ea6\u304c\u8584\u3044\u304b\u3089\u7d30\u80de\u306b\u53d6\u308a\u8fbc\u307e\u308c\u308b\u524d\u306b\u5206\u89e3\u3055\u308c\u3061\u3083\u3046\u78ba\u7387\u304c\u9ad8\u304f\u306a\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3002\u88fd\u85ac\u4f1a\u793e\u304c\u6cbb\u9a13\u3067\u884c\u3063\u305f\u65b9\u6cd5\u3068\u7570\u306a\u308b\u308f\u3051\u3067\u3001\u52b9\u679c\u304c\u3069\u3046\u306a\u308b\u304b\u308f\u304b\u3089\u306a\u3044\u3053\u3068\u306b\u306a\u308b\u3002<\/p>\n

\u6ce8\u5165\u91cf\u304c1.425 ml\u3068\u8a08\u7b97\u3055\u308c\u308b\u304c\u3001\u73fe\u5b9f\u306b\u306f 1.4 ml\u306b\u306a\u308b\u3060\u308d\u3046\u3002\u6709\u52b9\u6570\u5b57\u304c\uff13\u6841\u4ee5\u4e0a\u306a\u3069\u73fe\u5834\u3067\u306f\u3042\u308a\u3048\u306a\u3044\u304b\u3089\u306d\u3002\u30c7\u30b9\u30dd\u30fb\u30b7\u30e5\u30ea\u30f3\u30b8\u306e\u6700\u5c0f\u76ee\u76db\u308a\u306f 0.1 ml \u3067\u554f\u984c\u306a\u3044\u30021.5 ml \u306e\u307b\u3046\u304c\u3044\u3044\u3051\u3069\u91cf\uff08(1.5+0.15)*6 ml = 9.9 ml > 9.45 ml\uff09\u304c\u8db3\u308a\u306a\u304f\u306a\u308b\u30021.4 ml * 7.5 \u5358\u4f4d \/ 9.45 ml = 1.11\u5358\u4f4d\u3000\u3060\u304b\u3089\u6295\u4e0e\u91cf\u306f\u554f\u984c\u306a\u3044\u3002<\/p>\n

\u554f\u984c\u306f\u30d0\u30a4\u30a2\u30eb\u74f6\u306e\u5bb9\u91cf\u3060\u30029 ml \u52a0\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u304b\uff1f<\/p>\n

\u306a\u3093\u304b\u3001Open\u30d6\u30ed\u30b0\u306e\u3088\u3046\u306a\u7d20\u4eba\u8003\u3048\u3060\u306a\u3002\t\t<\/p>\n","protected":false},"excerpt":{"rendered":"

\u901a\u5e38\u4f7f\u3046disposable syringe \uff08\u4f7f\u3044\u6368\u3066\u6ce8\u5c04\u5668\uff09\u306e dead space \u304c\u5927\u304d\u304f\u3066\u3001COVID-19\u306e\u30ef\u30af\u30c1\u30f3\u304c\uff16\u540d\u5206\u306a\u306e\u306b\uff15\u540d\u5206\u3057\u304b\u6295\u4e0e\u3067\u304d\u306a\u3044\u3068\u554f\u984c\u306b\u306a\u3063\u3066\u3044\u308b\u3002 \u4ee5\u4e0b\u306b\u66f8\u3044\u305f\u306e\u306f\u8584\u3081\u3066\u6295\u4e0e\u3059\u308c\u3070\u3044 … \u7d9a\u304d\u3092\u8aad\u3080 \u6ce8\u5c04\u5668\u306e\u30c7\u30c3\u30c9\u30b9\u30da\u30fc\u30b9<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-18215","post","type-post","status-publish","format-standard","hentry","category-9"],"_links":{"self":[{"href":"https:\/\/nbsigh2.com\/index.php?rest_route=\/wp\/v2\/posts\/18215","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nbsigh2.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nbsigh2.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nbsigh2.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nbsigh2.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=18215"}],"version-history":[{"count":0,"href":"https:\/\/nbsigh2.com\/index.php?rest_route=\/wp\/v2\/posts\/18215\/revisions"}],"wp:attachment":[{"href":"https:\/\/nbsigh2.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=18215"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nbsigh2.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=18215"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nbsigh2.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=18215"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}