{"id":17960,"date":"2020-12-04T05:12:18","date_gmt":"2020-12-03T20:12:18","guid":{"rendered":"http:\/\/seigi.accsnet.ne.jp\/sigh\/blog\/?p=17960"},"modified":"2021-12-17T15:17:06","modified_gmt":"2021-12-17T06:17:06","slug":"google%e7%bf%bb%e8%a8%b3%e3%81%8c%e3%81%aa%e3%81%84%e3%81%a8","status":"publish","type":"post","link":"https:\/\/nbsigh2.com\/?p=17960","title":{"rendered":"Google\u7ffb\u8a33\u304c\u306a\u3044\u3068…"},"content":{"rendered":"

\u5f7c\u306e\u65b9\u304c\u8a18\u4e8b\u3092\u66f8\u304f\u3068\u3001\u30c4\u30c3\u30b3\u30df\u6240\u6e80\u8f09\u306a\u306e\u3067\u3001\u3042\u3063\u3068\u3044\u3046\u9593\u306b\u5f53\u65b9\u306e\u30b3\u30e1\u30f3\u30c8\u6b04\u304c100\u4ef6\u3092\u8d85\u3048\u3061\u3083\u3044\u307e\u3059\u3002\u30b3\u30e1\u30f3\u30c8\u6570\u306b\u5236\u9650\u306f\u306a\u3044\u306e\u3067\u3059\u304c\u3001\u30b3\u30e1\u30f3\u30c8\u6b04\u304c\u6298\u308a\u305f\u305f\u307e\u308c\u308b\u3068\u5f15\u7528\u304c\u9762\u5012\u306a\u306e\u3067\u3001\u65b0\u305f\u306a\u8a18\u4e8b\u3092\u7acb\u3061\u4e0a\u3052\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\u4eca\u56de\u3082\u3001\u89e3\u8aac\u3082\u3069\u304d\u8a18\u4e8b<\/a>\uff08\u9b5a\u62d3<\/a>\uff09\u3092\u5f7c\u306e\u65b9\u304c\u66f8\u3044\u305f\u306e\u3067\u3001\u3053\u308c\u3092\u53d7\u3051\u3066\u3001\u3068\u3044\u3046\u304b\u524d\u56de\u304b\u3089\u306e\u9023\u7d9a\u3067\u30b3\u30e1\u30f3\u30c8\u6b04\u3092\u4f5c\u308b\u305f\u3081\u306b\u8a18\u4e8b\u3092\u7acb\u3061\u4e0a\u3052\u307e\u3057\u305f\u3002<\/p>\n

\u7686\u69d8\u3001\u3069\u3046\u305e\u3054\u81ea\u7531\u306b\u30b3\u30e1\u30f3\u30c8\u3092\u6295\u7a3f\u304f\u3060\u3055\u3044\u3002<\/p>\n

\u30bf\u30a4\u30c8\u30eb\u306b\u5408\u3046\u8a18\u4e8b\u5185\u5bb9\u306f\u4ee5\u4e0b\u3067\u3001\u3068\u308a\u3042\u3048\u305a\u30b3\u30e1\u30f3\u30c8\u6b04\u3092\u4f5c\u308b\u305f\u3081\u306b\u7acb\u3061\u4e0a\u3052\u307e\u3059\u3002<\/p>\n

During mouse development, a single, totipotent cell divides repeatedly to give rise to a few billion cells, which differentiate into a few hundred different cell types.
\n\u3053\u306e\u90e8\u5206\u3092\u5358\u7d14\u306b\u30b0\u30fc\u30b0\u30eb\u8a33\u306b\u304b\u3051\u308b\u3068\u4ee5\u4e0b\u3067\u3059\u3002
\n\u300c\u30de\u30a6\u30b9\u306e\u767a\u80b2\u4e2d\u3001\u5358\u4e00\u306e\u5168\u80fd\u6027\u7d30\u80de\u304c\u7e70\u308a\u8fd4\u3057\u5206\u88c2\u3057\u3066\u6570\u5341\u5104\u500b\u306e\u7d30\u80de\u3092\u751f\u3058\u3001\u305d\u308c\u304c\u6570\u767e\u306e\u7570\u306a\u308b\u7d30\u80de\u578b\u306b\u5206\u5316\u3057\u307e\u3059\u3002\u300d
\n\uff08\u5358\u4e00\u306e\u5168\u80fd\u6027\u7d30\u80de\u306f\u53d7\u7cbe\u5375\u3067\u3059\u3002\u3053\u308c\u304c\u308f\u304b\u3089\u306a\u3044\u4eba\u304c\u3044\u307e\u3057\u305f\u3002\uff09<\/p><\/blockquote>\n

\uff08\u300c\u3000\u300d\u306f\u5f53\u65b9\u304c\u52a0\u7b46\uff09
\n\u53c2\u3063\u3061\u3083\u3046\u306d\u3002\u3053\u3093\u306a\u7c21\u5358\u306a\u82f1\u6587\u3092Google\u7ffb\u8a33\u3067\u8a33\u3055\u306a\u3044\u3068\u308f\u304b\u3089\u306a\u3044\u306e\u304b\uff1f\u305d\u308c\u3068\u3082\u521d\u5fc3\u8005\u7528\u306b\u89e3\u8aac\u3057\u3066\u3042\u3052\u3066\u3044\u308b\u3068\u3067\u3082\u8a00\u3046\u306e\u3067\u3059\u304b\u306d\u3002
\n\u89e3\u8aac\u3057\u3066\u3042\u3052\u3066\u3044\u308b\u3068\u3001\u9ad8\u6240\u304b\u3089\u5f53\u65b9\u7b49\u3092\u898b\u4e0b\u3057\u3066\uff08”\u3053\u308c\u304c\u308f\u304b\u3089\u306a\u3044\u4eba”\u3068\u306f\u5f53\u65b9\u306e\u3053\u3068\u3067\u3057\u3087\u3046\uff09\u66f8\u304f\u306e\u306a\u3089\u3001Google\u7ffb\u8a33\u3067\u306fdevelopment\u3092\u300c\u767a\u80b2\u4e2d\u300d\u3068\u8a33\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u3053\u3053\u3067\u306f\u80da\u767a\u751f\u306e\u8ad6\u6587\u306a\u306e\u3067\u300c\u767a\u751f\u300d\u3068\u3059\u3079\u304d\u3068\u304b\u3001\u4e0b\u3005\u306e\u65b9\u3005\u3078\u306f\u89e3\u8aac\u3059\u3079\u304d\u3067\u3057\u3087\u3046\u3002\u3057\u304b\u3057\u3001\u3053\u306e\u7ffb\u8a33\u3067\u6e80\u8db3\u3057\u3066\u3044\u308b\u65b9\u306b\u306f\u3001\u300c\u767a\u80b2\u300d\u3067\u3044\u3044\u306e\u3067\u3057\u3087\u3046\u306d\u3002\u7406\u7814\u306eCDB(Center for Developmental Biology)\u306e\u3001\u3053\u306e\u9a12\u304e\u306e\u524d\u306e\u65e5\u672c\u8a9e\u540d\u79f0\u306f\u300c\u767a\u751f\u30fb\u518d\u751f\u79d1\u5b66\u7dcf\u5408\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u300d\u3067\u3042\u3063\u305f\u3088\u3046\u306bdevelopment \u3092\u767a\u80b2\u306a\u3069\u3068\u79f0\u3057\u3066\u3044\u307e\u305b\u3093\u3002CDB\u306f\u5e7c\u7a1a\u5712\u3058\u3083\u306a\u3044\u304b\u3089\u306d\u3002<\/p>\n

\u79d1\u5b66\u7684\u8868\u73fe\u304c\u79c1\u305f\u3061\u306b\u306f\u308f\u304b\u308a\u306b\u304f\u3044\u306e\u3067\u3059\u3002<\/p><\/blockquote>\n

\u4f55\u3044\u3063\u3066\u3044\u308b\u3093\u3067\u3057\u3087\u3002\u5b66\u3068\u307f\u5b50\u3060\u3051\u3067\u3059\u3088\u3001\u308f\u304b\u308a\u306b\u304f\u3044\u3068\u601d\u3063\u3066\u3044\u308b\u306e\u306f\u3002among\u3084conserve\u3092\u6b63\u3057\u304f\u8a33\u305b\u306a\u304b\u3063\u305f<\/a>\u4eba\u306b\u306f\u308f\u304b\u308a\u306b\u304f\u3044\u306e\u3067\u3057\u3087\u3046\u306d\u3002<\/p>\n

Cell phenotypes\u306f\u3001\u4f53\u306e\u3044\u308d\u3044\u308d\u306a\u7d30\u80de\u3092\u6307\u3057\u307e\u3059\u304c\u3001\u3053\u3053\u3092\u7406\u89e3\u3059\u308b\u306e\u304c\u306a\u304b\u306a\u304b\u96e3\u3057\u3044\u3089\u3057\u3044\u3067\u3059\u3002
\n\u3068\u306b\u304b\u304f\u3001\u5927\u5b66\u306e\u5148\u751f\u306e\u982d\u3067\u3082\u3001\u3053\u3053\u304c\u76f4\u306b\u5165\u3063\u3066\u3044\u3051\u306a\u3044\u3088\u3046\u3067\u3057\u305f\u306d\u3002\n<\/p><\/blockquote>\n

\u3053\u306e\u300c\u5927\u5b66\u306e\u5148\u751f\u300d\u3068\u306f\u5f53\u65b9\u306e\u3053\u3068\u306e\u3088\u3046\u3067\u3059\u3002\u5f53\u65b9\u306e\u3088\u3046\u306a\u4e0b\u3005\u306b\u89e3\u8aac\u3092\u3057\u305f\u3044\u306e\u306a\u3089\u3001\u6b63\u78ba\u306b\u884c\u3063\u3066\u307b\u3057\u3044\u3082\u306e\u3067\u3059\u3002\u300ca few hundred different cell types\u300d\u306f\u300cCell phenotypes\u300d\u3067\u306f\u306a\u3044\u3067\u3059\u306d\u3002\u4e39\u7fbd\u6c0f\u306eIntroduction\u306f\u3053\u306e\u5f8c<\/p>\n

Cell phenotypes are defined by particular combinationsof genes expressed in a cell type-dependent manner.<\/p><\/blockquote>\n

\u3068\u3042\u308a\u307e\u3059\u3088\u3046\u306b\u3001Phenotype=\u8868\u73fe\u578b\u306f\u7d30\u80de\u306e\u7a2e\u985e\u3092\u6307\u3059\u8a00\u8449\u3067\u306f\u306a\u304f\u3001\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u306e\u7d50\u679c\u306e\u7d30\u80de\u306e\u30bf\u30a4\u30d7\u3068\u3044\u3046\u3088\u3046\u306a\u610f\u5473\u3067\u4f7f\u3046\u306e\u306a\u3089\u3044\u3044\u306e\u3067\u3059\u304c\u3001\u5358\u7d14\u306b<\/p>\n

Cell phenotypes\u306f\u3001\u4f53\u306e\u3044\u308d\u3044\u308d\u306a\u7d30\u80de\u3092\u6307\u3057\u307e\u3059<\/p><\/blockquote>\n

\u306a\u3069\u3068\u8a00\u3046\u3079\u304d\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n

\u3053\u306e\u3088\u3046\u306bCell phenotypes \u3092\u201c\u7d30\u80de\u306e\u8868\u73fe\u578b\u201d\u3068\u8a33\u3055\u305a\u3001\u4f53\u306e\u4e2d\u306e\u3044\u308d\u3044\u308d\u306a\u7a2e\u985e\u306e\u7d30\u80de\u3068\u7f6e\u304d\u63db\u3048\u308b\u3068\u3001\u3060\u308c\u3067\u3082\u7406\u89e3\u3067\u304d\u307e\u3059\u3002\n<\/p><\/blockquote>\n

\u306a\u3069\u3068\u30c7\u30bf\u30e9\u30e1\u89e3\u8aac\u306f\u3059\u3079\u304d\u3067\u306f\u306a\u3044\u3067\u3059\u306d\u3002\u4e0b\u3005\u3067\u3082\u7d30\u80de\u306e\u7a2e\u985e\u3068\u8868\u73fe\u578b\u306e\u7a2e\u985e\u3068\u306f\u7570\u306a\u3063\u305f\u610f\u5473\u306a\u306e\u3067\u5358\u7d14\u306b\u7d50\u3073\u3064\u3051\u308b\u306e\u306f\u8aa4\u308a\u3067\u3059\u3002<\/p>\n

\u4e39\u7fbd\u7dcf\u8aac\u306f\u3001\u666e\u901a\u306e\u4eba\u3067\u3082\u60f3\u50cf\u3067\u304d\u308b\u8a00\u8449\u306b\u7f6e\u304d\u63db\u3048\u308b\u3068\u3001\u7279\u5225\u306b\u96e3\u3057\u3044\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p><\/blockquote>\n

\u305d\u3093\u306a\u3053\u3068\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u5c02\u9580\u96d1\u8a8c\u306b\u63b2\u8f09\u3055\u308c\u305f\u5c02\u9580\u8ad6\u6587\u3067\u3059\u304b\u3089\u3001\u975e\u5c02\u9580\u5bb6\u304c\u5b66\u3068\u307f\u5b50\u306e\u3088\u3046\u306b\u5c02\u9580\u7528\u8a9e\u3092\u52dd\u624b\u306b\u81ea\u5df1\u6d41\u306b\u7f6e\u304d\u63db\u3048\u3066\u7406\u89e3\u3059\u308b\u3068\u8aa4\u89e3\u3057\u307e\u3059\u3002<\/p>\n

\u4e39\u7fbd\u6c0f\u306f\u7dcf\u8aac\u3067different cell types\u3068cell phenotypes \u3068\u4f7f\u3044\u5206\u3051\u3066\u3044\u308b\u306e\u3067\u540c\u4e00\u8996\u3059\u3079\u304d\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n

\u5c02\u9580\u5bb6\u3067\u306f\u306a\u3044\u65b9\u306f\u5c02\u9580\u5bb6\u306b\u805e\u304f\u3079\u304d\u3067\u3059\u306d\u3002Introduction\u306e\u4e00\u90e8\u304cBox 1,2 \u3067\u3042\u308b\u3068\u89e3\u91c8\u3059\u308b\u3088\u3046\u306a\u30a4\u30f3\u30c1\u30ad\u81ea\u79f0\u79d1\u5b66\u3092\u8ad6\u305a\u308b\u8005\u306e\u610f\u898b\u306f\u805e\u304b\u306a\u3044\u65b9\u304c\u3044\u3044\u3067\u3059\u306d\u3002\u3000<\/p>\n

\u8ffd\u8a18\u3000\u3053\u306e\u8a18\u4e8b\u306e\u524d\u534a\u3092\u8aad\u3093\u3060\u5b66\u3068\u307f\u5b50\u306f<\/p>\n

\u3053\u306e\uff08\u672c\u8a18\u4e8b\u306e\uff09\u30bf\u30a4\u30c8\u30eb\u306f\u3072\u3069\u3059\u304e\u308b\u3002\u305f\u3081\u606f\u3055\u3093\u306e\u8cc7\u8cea\u3092\u554f\u308f\u308c\u308b\u3068\u3044\u3046\u610f\u5473\u3067\u3001<\/p><\/blockquote>\n

\u3072\u3069\u3059\u304e\u307e\u305b\u3093\u3002Google\u7ffb\u8a33\u306f\u4fbf\u5229\u306a\u306e\u3067\u4f7f\u3046\u3053\u3068\u3092\u5426\u5b9a\u306a\u3069\u3057\u307e\u305b\u3093\u3002\u9053\u5177\u3067\u3059\u304b\u3089\u4fbf\u5229\u306a\u9053\u5177\u306f\u52b9\u7387\u3092\u4e0a\u3052\u308b\u305f\u3081\u306b\u4f7f\u3046\u3079\u304d\u3067\u3059\u3002\u5f53\u65b9\u3082\u4f7f\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u5b66\u3068\u307f\u5b50\u304c\u5f15\u7528\u3057\u305f\u4e39\u7fbd\u6c0f\u7dcf\u8aac\u306eIntroduction\u5192\u982d\u306e\u6587\u306f\u3001\u3044\u304f\u3089\u306a\u3093\u3067\u3082Google\u7ffb\u8a33\u3092\u5229\u7528\u3057\u306a\u3044\u3068\u308f\u304b\u3089\u306a\u3044\u82f1\u6587\u3067\u306f\u306a\u3044\u3067\u3057\u3087\u3046\u3002<\/p>\n

\u5f53\u65b9\u304c\u3053\u306e\u3088\u3046\u306a\u30bf\u30a4\u30c8\u30eb\u3067\u8a18\u4e8b\u3092\u66f8\u3044\u305f\u610f\u5473\u304c\u7406\u89e3\u3067\u304d\u306a\u3044\u306e\u306a\u3089\u3001\u305d\u308c\u3067\u3044\u3044\u3067\u3059\u3051\u3069\u306d\u3002\u5f53\u65b9\u306e\u8cc7\u8cea\u3092\u554f\u3046\u65b9\u304c\u3044\u305f\u3089\u30b3\u30e1\u30f3\u30c8\u304f\u3060\u3055\u3044\u3002\t\t<\/p>\n","protected":false},"excerpt":{"rendered":"

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