{"id":17787,"date":"2020-10-01T13:57:20","date_gmt":"2020-10-01T04:57:20","guid":{"rendered":"http:\/\/seigi.accsnet.ne.jp\/sigh\/blog\/?p=17787"},"modified":"2021-12-17T15:07:31","modified_gmt":"2021-12-17T06:07:31","slug":"%e8%aa%a4%e8%a8%b3%e3%81%97%e3%81%9f%e7%90%86%e7%94%b1","status":"publish","type":"post","link":"https:\/\/nbsigh2.com\/?p=17787","title":{"rendered":"\u8aa4\u8a33\u3057\u305f\u7406\u7531"},"content":{"rendered":"<p><a href=\"https:\/\/katura1.blog.fc2.com\/blog-entry-1372.html\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">\u4e00\u3064\u306e\u8ee2\u6a5f\u3092&#8230;<\/a>\uff08<a href=\"https:\/\/archive.is\/wip\/AH7JEL\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">\u9b5a\u62d3<\/a>\uff09\u306e\u8a18\u4e8b\u304b\u3089\u3002<\/p>\n<p>\u3048\u3048\u3048\uff1f\u5b66\u3068\u307f\u5b50\u66f0\u304f\uff1a<\/p>\n<blockquote><p>\u305f\u3081\u606f\u3055\u3093\u306f\u4e00\u90e8\u3092\u898b\u3066\u3001\u81ea\u3089\u306e\u4e4f\u3057\u3044\u6587\u6cd5\u306e\u81f3\u4e0a\u4e3b\u7fa9\u3092\u632f\u308a\u56de\u3057\u3066\u3001\u9593\u9055\u3044\u65e5\u672c\u8a9e\u8868\u73fe\u3092\u3057\u3066\u3057\u307e\u3046\u3088\u3046\u3067\u3059\u3002<br \/>\n[\uff13\u3064\u306e\u8ee2\u5199\u56e0\u5b50\u304c\u80ce\u76e4\u5f62\u6210\u306b\u95a2\u4fc2\u3059\u308b\u3093\u3060\u306a]\u3068\u3001\u8aad\u8005\u306b\u8aa4\u89e3\u3092\u4e0e\u3048\u308b\u65e5\u672c\u8a9e\u8868\u8a18\u3057\u305f\u3089\u3082\u3046\u7d42\u308f\u308a\u3067\u3059\u3002<\/p><\/blockquote>\n<p><a href=\"https:\/\/dev.biologists.org\/content\/develop\/145\/6\/dev157420.full.pdf\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">\u4e39\u7fbd\u6c0f\u7dcf\u8aac<\/a> p10 \u53f3\u30b3\u30e9\u30e0\u306e\u4e0a\u306e\u65b9\u3002<\/p>\n<blockquote><p>they cooperate together to define an evolutionarily new cell type, the trophoblast.<\/p><\/blockquote>\n<p>they \u306fSox2\u3001 Eomes\u3001Cdx2\u306e\uff13\u3064\u306e\u8ee2\u5199\u56e0\u5b50\u3067\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u306f\u3001\u3044\u304f\u3089\u5b66\u3068\u307f\u5b50\u3067\u3082\u8a8d\u3081\u308b\u3067\u3057\u3087\uff1f<br \/>\ntrophoblast\u3000\u3068\u306f\u5c06\u6765\u80ce\u76e4\u306e\u4e00\u90e8\u306b\u306a\u308b\u80da\u306e\u90e8\u5206\u3067\u3059\u3088\u306d\u3002<br \/>\n\u3060\u3068\u3057\u305f\u3089\u3001\u3053\u306e\u6587\u306b\u300c\uff13\u3064\u306e\u8ee2\u5199\u56e0\u5b50\u304c\u80ce\u76e4\u5f62\u6210\u306b\u95a2\u4fc2\u3059\u308b\u300d\u4ee5\u5916\u306e\u3069\u3093\u306a\u610f\u5473\u304c\u3042\u308b\u306e\u3067\u3057\u3087\uff1f\u3053\u306e\u90e8\u5206\u3092\u8aa4\u8a33\u3057\u3066\u3044\u308b\u7406\u7531\u306f\u3044\u307e\u306e\u3068\u3053\u308d\u4e0d\u660e\u3067\u3059\u3002\u5358\u7d14\u306b\u82f1\u8a9e\u3092\u8aad\u3081\u306a\u3044\u3068\u3057\u3066\u3082\u3001\u3069\u3046\u3084\u3063\u3066\u3053\u3093\u306a\u5984\u60f3\u306b\u81f3\u3063\u305f\u306e\u304b\u304c\u308f\u304b\u308a\u307e\u305b\u3093\u3002<\/p>\n<p>\u5b66\u3068\u307f\u5b50\u66f0\u304f\uff1a<\/p>\n<blockquote><p>\u5f7c\u3089\u306f\u3001[\u8a33]\u3068\u3044\u3046\u8a8d\u8b58\u304b\u3089\u96e2\u308c\u3089\u308c\u306a\u3044\u306e\u3067\u3059\u3002[\u5f15\u304d\u7d99\u304c\u308c\u308b]\u3068\u3044\u3046\u8868\u73fe\u3092\u6b63\u3057\u304f\u7406\u89e3\u3059\u308b\u4eba\u306b\u5411\u3051\u3066\u3001\u5b66\u3068\u307f\u5b50\u306e\u8a00\u8449\u306f\u3001(\u8a33\u3067\u306a\u304f)\u8aac\u660e\u3067\u3059\u3002<\/p><\/blockquote>\n<p><a href=\"https:\/\/nbsigh2.com\/?p=17779#comment-163755\" target=\"_blank\" rel=\"noopener noreferrer\">\u524d\u8a18\u4e8b\u306e\u30b3\u30e1\u30f3\u30c8<\/a>\u306b\u66f8\u304d\u307e\u3057\u305f\u304c\u3001\u5b66\u3068\u307f\u5b50\u306f\u6c7a\u5b9a\u7684\u306a\u8aa4\u308a\u3092\u3057\u3066\u3044\u308b\u308f\u3051\u3067\u3059\u3002<\/p>\n<blockquote><p>TS\u306b\u4fdd\u5b58\u3055\u308c\u305f\u8ee2\u5199\u56e0\u5b50Sox2, Eomes Cdx2 \u304c\u3001\u305d\u306e\u5f8c\u306e\u5185\u3001\u4e2d\u3001\u5916\u306e\uff13\u80da\u8449\u7cfb\u306e\u7d30\u80de\u5206\u5316\u3001neuroectoderm, mesoendoderm\u3001definitive endoderm\u3000\u306b\u5f15\u304d\u7d99\u304c\u308c\u3066\u3044\u308b<\/p><\/blockquote>\n<p>\u3068\u89e3\u91c8\u3057\u305f\u306e\u3067\u3059\u3002among \u3092 TS\uff08\u80ce\u76e4\u5e79\u7d30\u80de\uff09\u306e\u4e2d\uff1d\u5185\u90e8\u3068\u8aa4\u8a33\u3057\u3001conserve\u3000\u3092\u4fdd\u5b58\u3068\u3000\u8a33\u3057\u305f\u3082\u3093\u3060\u304b\u3089\u3001\u3081\u3061\u3083\u304f\u3061\u3083\u306a(\u8a33\u3067\u306a\u304f)\u8aac\u660e\u306b\u306a\u3063\u3061\u3083\u3063\u305f\u308f\u3051\u3067\u3059\u3002\u6570\u591a\u304f\u306e\u8ee2\u5199\u56e0\u5b50\u306eamong\u4e2d\u304b\u3089\u3001\u9032\u5316\u7684\u3001\u7cfb\u7d71\u767a\u751f\u7684\u306b\u53e4\u304f\u304b\u3089\u4fdd\u305f\u308c\u3066conserved\u3044\u308b\u6a5f\u80fd\u306e\u3042\u308b\uff13\u3064\u306e\u8ee2\u5199\u56e0\u5b50\u3000\u306e\u610f\u5473\u3067\u3059\u3002<\/p>\n<p>\u3064\u307e\u308a\u3001\u3053\u3053\u3067\u3082\u5b66\u3068\u307f\u5b50\u306f\u77e5\u3063\u3066\u3044\u308b\u82f1\u5358\u8a9e\u3000among\u3001 conserve \u3092\u767a\u898b\u3057\u3001\u5984\u60f3\u8133\u5185\u3067\u30b9\u30c8\u30fc\u30ea\u30fc\u3092\u52dd\u624b\u306b\u69cb\u7bc9\u3057\u305f\u305f\u3081\u306b\u3001\u300c\u5185\u90e8\u300d\u3068\u300c\u4fdd\u5b58\u300d\u3068\u304b\u3089\u3000are found \u3092\u300c\u5f15\u304d\u7d99\u304c\u308c\u3066\u3044\u308b\u300d\u3068\u8a33\u3057\u3066&#8221;\u8aac\u660e&#8221;\u3057\u305f\u308f\u3051\u306a\u306e\u3067\u3001\u610f\u5473\u304c\u672c\u6765\u304b\u3089\u5168\u304f\u5225\u306b\u306a\u3063\u3066\u3057\u307e\u3063\u305f\u308f\u3051\u3067\u3059\u3002<\/p>\n<p>\u3072\u3087\u3063\u3068\u3057\u3066\u3001Google\u7ffb\u8a33\u306f\u306a\u3093\u304b\u7a81\u62cd\u5b50\u3082\u306a\u3044\u8a33\u3092\u793a\u3057\u3066\u3044\u3066\u5b66\u3068\u307f\u5b50\u304c\u5229\u7528\u3057\u305f\u306e\u304b\u3068\u601d\u3063\u3066\u3001\u7ffb\u8a33\u3055\u305b\u305f\u3089<\/p>\n<blockquote><p>TSC\u56fa\u6709\u306e\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u306e\u8ee2\u5199\u56e0\u5b50\u306e\u4e2d\u3067\u3001Sox2\u3001Eomes\u3001\u304a\u3088\u3073Cdx2\u306e\u9032\u5316\u7684\u306b\u4fdd\u5b58\u3055\u308c\u305f\u6a5f\u80fd\u306f\u3001\u305d\u308c\u305e\u308c\u795e\u7d4c\u5916\u80da\u8449\u3001\u4e2d\u5185\u80da\u8449\u3001\u304a\u3088\u3073\u80da\u4f53\u5185\u80da\u8449\u306b\u898b\u3089\u308c\u307e\u3059\u3002<\/p><\/blockquote>\n<blockquote><p>\u305d\u308c\u3089\u306f\u5354\u529b\u3057\u3066\u3001\u9032\u5316\u7684\u306b\u65b0\u3057\u3044\u7d30\u80de\u30bf\u30a4\u30d7\u3067\u3042\u308b\u6804\u990a\u819c\u3092\u5b9a\u7fa9\u3057\u307e\u3059\u3002<\/p><\/blockquote>\n<p>\u3067\u3057\u305f\u3002\u307e\u3068\u3082\u3067\u3059\u306a\u3002\u5f53\u7136\u3067\u3059\u306a\u3002define \u3092\u5b9a\u7fa9\u3059\u308b\u3000\u3068\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u6c7a\u5b9a\u3065\u3051\u308b\u3000\u3068\u3044\u3046\u610f\u5473\u306e\u307b\u3046\u304c\u3044\u3044\u3067\u3059\u306d\u3002\u3053\u3093\u306a\u77ed\u3044\u6587\u306a\u306e\u306b\u5b66\u3068\u307f\u5b50\u306f\u8aad\u3081\u306a\u3044\u306e\u304b\u3002<\/p>\n<p>\u4f55\u304b\u3001\u5b66\u3068\u307f\u5b50\u306f\u3081\u3061\u3083\u3081\u3061\u3083\u306b\u58ca\u308c\u3061\u3083\u3063\u305f\u3088\u3046\u3067\u3059\u306a\u3002\u82f1\u8a9e\u304c\u8aad\u3081\u306a\u3044\u306e\u524d\u306e\u6bb5\u968e\u306e\u3088\u3046\u3067\u3059\u306a\u3002<\/p>\n<p><a href=\"https:\/\/nbsigh2.com\/wp-content\/uploads\/2020\/10\/2020100kiroujyouhototogisu.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-17790 size-medium\" src=\"https:\/\/nbsigh2.com\/wp-content\/uploads\/2020\/10\/2020100kiroujyouhototogisu-300x300.png\" alt=\"\" width=\"300\" height=\"300\" \/><\/a><br \/>\n\u30ad\u30a4\u30b8\u30e7\u30a6\u30ed\u30a6\u30db\u30c8\u30c8\u30ae\u30b9\t\t<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e00\u3064\u306e\u8ee2\u6a5f\u3092&#8230;\uff08\u9b5a\u62d3\uff09\u306e\u8a18\u4e8b\u304b\u3089\u3002 \u3048\u3048\u3048\uff1f\u5b66\u3068\u307f\u5b50\u66f0\u304f\uff1a \u305f\u3081\u606f\u3055\u3093\u306f\u4e00\u90e8\u3092\u898b\u3066\u3001\u81ea\u3089\u306e\u4e4f\u3057\u3044\u6587\u6cd5\u306e\u81f3\u4e0a\u4e3b\u7fa9\u3092\u632f\u308a\u56de\u3057\u3066\u3001\u9593\u9055\u3044\u65e5\u672c\u8a9e\u8868\u73fe\u3092\u3057\u3066\u3057\u307e\u3046\u3088\u3046\u3067\u3059\u3002 [\uff13\u3064\u306e\u8ee2\u5199\u56e0\u5b50\u304c\u80ce\u76e4\u5f62\u6210\u306b\u95a2\u4fc2\u3059\u308b\u3093\u3060\u306a] &hellip; <a href=\"https:\/\/nbsigh2.com\/?p=17787\" class=\"more-link\">\u7d9a\u304d\u3092\u8aad\u3080 <span class=\"screen-reader-text\">\u8aa4\u8a33\u3057\u305f\u7406\u7531<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2,8],"tags":[],"class_list":["post-17787","post","type-post","status-publish","format-standard","hentry","category-education","category-fake"],"_links":{"self":[{"href":"https:\/\/nbsigh2.com\/index.php?rest_route=\/wp\/v2\/posts\/17787","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nbsigh2.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nbsigh2.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nbsigh2.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nbsigh2.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=17787"}],"version-history":[{"count":1,"href":"https:\/\/nbsigh2.com\/index.php?rest_route=\/wp\/v2\/posts\/17787\/revisions"}],"predecessor-version":[{"id":20211,"href":"https:\/\/nbsigh2.com\/index.php?rest_route=\/wp\/v2\/posts\/17787\/revisions\/20211"}],"wp:attachment":[{"href":"https:\/\/nbsigh2.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=17787"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nbsigh2.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=17787"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nbsigh2.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=17787"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}