{"id":15511,"date":"2019-05-15T09:52:48","date_gmt":"2019-05-15T00:52:48","guid":{"rendered":"http:\/\/seigi.accsnet.ne.jp\/sigh\/blog\/?p=15511"},"modified":"2021-12-12T14:34:15","modified_gmt":"2021-12-12T05:34:15","slug":"%e3%81%8a%e7%ad%94%e3%81%88%e3%81%97%e3%81%be%e3%81%99","status":"publish","type":"post","link":"https:\/\/nbsigh2.com\/?p=15511","title":{"rendered":"\u4e0d\u8ebe\u306a\u8cea\u554f\u3067\u3059\u304c\u304a\u7b54\u3048\u3057\u307e\u3059"},"content":{"rendered":"

\u300c\u3053\u306eplus\u6c0f\u306e\u8003\u5bdf\u306b\u5bfe\u3057\u3001\u305f\u3081\u606f\u6c0f\u3001oTake\u6c0f\u306f\u3001\u3069\u306e\u3088\u3046\u306a\u8003\u5bdf\u3092\u3057\u3066\u304f\u308b\u306e\u304b\u3001\u305d\u306e\u89e3\u8aac\u3092\u5f85\u3064\u4e8b\u306b\u3057\u307e\u3057\u3087\u3046\u3002<\/a>\u300d\uff08\u9b5a\u62d3<\/a>\uff09 \u3068\u3044\u3046\u8a18\u4e8b\u3067\u3001\u8cea\u554f\u306b\u306f\u7b54\u3048\u305a\u81ea\u5206\u306e\u610f\u898b\u3092\u8a00\u308f\u305a\u306b\u4ed6\u4eba\u306b\u610f\u898b\u3092\u6c42\u3081\u308b\u3068\u3044\u3046\u5b66\u3068\u307f\u5b50\u304b\u3089\u306e\u4e0d\u8ebe\u306a\u8cea\u554f\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u7b54\u3048\u305f\u304f\u306a\u3044\u306e\u3067\u3059\u304c\u3001\u62d9\u30d6\u30ed\u30b0\u7ba1\u7406\u4eba\u306f\u4eba\u304c\u3044\u3044\u306e\u3067\u7b54\u3048\u3066\u307f\u308b\u3053\u3068\u306b\u3057\u307e\u3059\u3002
\n\uff1e\u5b66\u3068\u307f\u5b50\u69d8
\nReviewer 2 \u306e\u3000\u30b3\u30e1\u30f3\u30c810\uff09\u306b\u3064\u3044\u3066\u3067\u3059\u3002\u3053\u306e\u30b3\u30e1\u30f3\u30c8\u306f\uff1a<\/p>\n

10) It is stated that there was no differentiation tendency of SACs derived from any tissues when incorporated into chimeras. This does not appear to be true as liver-derived SACs exhibit a low contribution, and are skewed to liver differentiation. Similarly, skin-derived SACs appear to demonstrate a tendency to contribute to the skin.<\/p><\/blockquote>\n

\u3067\u3059\u3002\u3053\u308c\u3092\u5b66\u3068\u307f\u5b50\u69d8\u306f\uff1b<\/p>\n

\uff11\uff10\uff09\u7d44\u7e54\u7531\u6765\u306e\uff33\uff21\uff23\u304c\u30ad\u30e1\u30e9\u306b\u53d6\u308a\u8fbc\u307e\u308c\u305f\u5834\u5408\u3001\u3044\u304b\u306a\u308b\u5206\u5316\u50be\u5411\u3082\u306a\u304b\u3063\u305f\u3068\u8ff0\u3079\u3089\u308c\u3066\u3044\u308b\u3002\u809d\u81d3\u7531\u6765\u306eSAC\u306f\u81d3\u5668\u5bc4\u4e0e\u304c\u4f4e\u3044\u304c\u3001\u809d\u81d3\u306e\u5206\u5316\u306b\u504f\u3063\u3066\u3044\u308b\u305f\u3081\u3001\u3053\u308c\u306f\u6b63\u3057\u304f\u306a\u3044\u3088\u3046\u3067\u3059\u3002\u540c\u69d8\u306b\u3001\u76ae\u819a\u7531\u6765\u306e\uff33\uff21\uff23\u306f\u76ae\u819a\u306b\u5bc4\u4e0e\u3059\u308b\u50be\u5411\u3092\u793a\u3059\u3088\u3046\u306b\u601d\u308f\u308c\u308b\u3002<\/span><\/p><\/blockquote>\n

\u3068\u30b3\u30e1\u30f3\u30c8\u3057\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089 Google\u7ffb\u8a33\u3067\u7ffb\u8a33\u3059\u308b\u3068\uff1b<\/p>\n

10\uff09\u30ad\u30e1\u30e9\u306b\u53d6\u308a\u8fbc\u307e\u308c\u305f\u5834\u5408\u3001\u3044\u304b\u306a\u308b\u7d44\u7e54\u7531\u6765\u306eSAC\u306e\u5206\u5316\u50be\u5411\u3082\u306a\u304b\u3063\u305f\u3068\u8ff0\u3079\u3089\u308c\u3066\u3044\u308b\u3002 \u809d\u81d3\u7531\u6765\u306eSAC\u306f\u5bc4\u4e0e\u304c\u4f4e\u304f\u3001\u809d\u81d3\u306e\u5206\u5316\u306b\u504f\u3063\u3066\u3044\u308b\u305f\u3081\u3001\u3053\u308c\u306f\u6b63\u3057\u304f\u306a\u3044\u3088\u3046\u3067\u3059\u3002 \u540c\u69d8\u306b\u3001\u76ae\u819a\u7531\u6765\u306e\uff33\uff21\uff23\u306f\u76ae\u819a\u306b\u5bc4\u4e0e\u3059\u308b\u50be\u5411\u3092\u793a\u3059\u3088\u3046\u306b\u601d\u308f\u308c\u308b\u3002<\/p><\/blockquote>\n

\u3068\u306a\u307e\u3059\u3002\u3053\u308c\u3092\u898b\u3066\u304a\u308f\u304b\u308a\u306e\u3088\u3046\u306b\u300c\u5b66\u3068\u307f\u5b50\u306e\u898b\u89e3\u306f\u3001\u8336\u5b57\u3067\u793a\u3057\u307e\u3057\u305f\u3068\u304a\u308a\u3067\u3001plus\u8aac\u3068\u306f\u5168\u304f\u3001\u7570\u306a\u308a\u307e\u3059\u3002<\/span>\u305d\u3082\u305d\u3082\u3001plus\u8aac\u304c\u306a\u305c\u3001\u305d\u3046\u306a\u308b\u306e\u304b\u304c\u308f\u304b\u308a\u307e\u305b\u3093\u3002<\/span>\u300d\u3068\u3042\u308a\u307e\u3059\u304c\u3001\u5b66\u3068\u307f\u5b50\u69d8\u306e\u898b\u89e3\u3084\u610f\u898b\u306f\u3053\u3053\u306b\u4f55\u3082\u3042\u308a\u307e\u305b\u3093\u3002plus99%\u3055\u3093\u306e\u610f\u898b\u3092\u7406\u89e3\u3067\u304d\u306a\u3044\u306e\u3067\u3059\u304b\uff1f\u5f53\u65b9\u306f\u4ee5\u4e0b\u306e\u3088\u3046\u306bplus99%\u3055\u3093\u306e\u610f\u898b\u306b\u7570\u8b70\u306f\u3042\u308a\u307e\u305b\u3093\u3002
\n\u5b66\u3068\u307f\u5b50\u69d8\u306eReviewer 2 \u306e\u30b3\u30e1\u30f3\u30c8\u3078\u306e\u610f\u898b\u306f\u3069\u306e\u3088\u3046\u306a\u306e\u3067\u3057\u3087\u3046\u304b\uff1f\u5358\u306b\u91cd\u8981\u3060\u3068\u304b\u306e\u7b54\u3048\u3067\u306f\u306a\u304f\u3001\u301c\u3060\u304b\u3089\u301c\u306e\u3088\u3046\u306b\u91cd\u8981\u3060\u3068\u5177\u4f53\u7684\u306b\u304a\u7b54\u3048\u304f\u3060\u3055\u3044\u3002
\nScience\u6295\u7a3f\u8ad6\u6587\u306e\u5b9f\u9a13\u7d50\u679c\u304c\u308f\u304b\u3089\u306a\u3044\u306e\u3067\u3001Reviewer 2 \u304c\u3069\u306e\u3088\u3046\u306a\u5b9f\u9a13\u7d50\u679c\u3092\u898b\u3066\u3053\u306e\u3088\u3046\u306a\u30b3\u30e1\u30f3\u30c8\u3092\u3057\u305f\u306e\u304b\u308f\u304b\u308a\u307e\u305b\u3093\u3002\u809d\u81d3\u7531\u6765\u3068\u76ae\u819a\u7531\u6765\u306eSTAP(SAC)\u7d30\u80de\u306e\u30ad\u30e1\u30e9\u52d5\u7269\u306e\u81d3\u5668\u5225\u8ca2\u732e\u5ea6\u3092\u8abf\u3079\u305f\u5b9f\u9a13\u7d50\u679c\u306e\u3088\u3046\u3067\u3059\u304c\u3001\u5b9f\u9a13\u7d50\u679c\u304c\u308f\u304b\u3089\u306a\u3044\u306e\u3067\u3001Reviewer 2 \u306e\u30b3\u30e1\u30f3\u30c8\u304c\u6b63\u5f53\u306a\u306e\u304b\u3001\u7121\u8996\u3059\u3079\u304d\u3044\u3061\u3083\u3082\u3093\u306a\u306e\u304b\u5224\u65ad\u3067\u304d\u307e\u305b\u3093\u3002Nature Article \u306e\u5b9f\u9a13\u7d50\u679c\u3067\u81d3\u5668\u5225\u8ca2\u732e\u5ea6\u3092\u793a\u3059\u306e\u306fFig.4d \u3067\u3059\u3002\u300cCD45+ cell-derived STAP cells contributed to all tissues examined (Fig. 4d).\u300d\u3068\u672c\u6587\u306b\u3042\u308a\u307e\u3059\u3002\u9178\u6d74\u3057\u3066\u521d\u671f\u5316\u3057\u305f\u767d\u8840\u7403\u304b\u3089\u30ad\u30e1\u30e9\u52d5\u7269\u3092\u4f5c\u308b\u3068\u8abf\u3079\u305f\u9650\u308a\u3069\u306e\u81d3\u5668\u306b\u3082\u306a\u308a\u5f97\u308b\u3068\u3044\u3046\u3053\u3068\u3092\u8a3c\u660e\u3057\u305f\u3068\u3059\u308b\u3082\u306e\u3067\u3001\u81d3\u5668\u5225\u306b\u5dee\u304c\u3042\u308b\u304b\u3069\u3046\u304b\u306f\u3053\u3061\u3089\u3067\u306f\u554f\u984c\u306b\u3057\u3066\u3044\u306a\u3044\u3088\u3046\u3067\u3059\u3002\u5dee\u304c\u3042\u308b\u3068\u3057\u305f\u3089\u3001\u53d7\u7cbe\u5375\u4e26\u306e\u5b8c\u5168\u306a\u521d\u671f\u5316\u3067\u306f\u306a\u3044\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u306e\u3067\u3001\u554f\u984c\u306b\u3057\u306a\u304b\u3063\u305f\u306e\u3067\u3057\u3087\u3046\u3002
\nScience \u6295\u7a3f\u8ad6\u6587\u306b\u3057\u308dNature\u306e\u305d\u308c\u306b\u3057\u308d\u3001\u5c0f\u4fdd\u65b9\u6c0f\u306f\u751f\u30c7\u30fc\u30bf\u30fb\u5b9f\u9a13\u8a18\u9332\u3092\u8abf\u67fb\u59d4\u54e1\u4f1a\u306b\u63d0\u793a\u3057\u306a\u304b\u3063\u305f\u306e\u3067\u3001\u3053\u306e\u5b9f\u9a13\u304c\u6b63\u3057\u304f\u884c\u308f\u308c\u305f\u306e\u304b\u634f\u9020\u306a\u306e\u304b\u4e0d\u660e\u3067\u3059\u3002\u4fe1\u7528\u3067\u304d\u307e\u305b\u3093\u3057\u3001\u8ab0\u3082\u518d\u73fe\u3067\u304d\u306a\u3044\u306e\u3067\u3001\u3053\u308c\u3092\u4eca\u66f4\u8b70\u8ad6\u3059\u308b\u3053\u3068\u306b\u610f\u7fa9\u306f\u898b\u3044\u3060\u305b\u307e\u305b\u3093\u3002\u305d\u308c\u3067\u3082\u5f37\u5f15\u306b\u7a7a\u60f3\u3059\u308b\u3068\u3001\u7531\u6765\u306b\u3088\u3063\u3066\u81d3\u5668\u3054\u3068\u306b\u5bc4\u4e0e\u3059\u308b\u7a0b\u5ea6\u304c\u7570\u306a\u308b\u306e\u306a\u3089\u3001\u9178\u6d74\u306b\u3088\u308b\u521d\u671f\u5316\u306f\u5b8c\u5168\u306a\u521d\u671f\u5316\u3067\u306f\u306a\u304f\u3001\u5143\u306e\u7d30\u80de\u306e\u6b74\u53f2\u3092\u5f15\u304d\u305a\u3063\u3066\u3044\u308b\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308a\u3001\u80ce\u76e4\u306b\u306a\u3063\u305f\u308a\u751f\u6b96\u7d30\u80de\u306b\u306a\u3063\u305f\u308a\u3059\u308b\u3068\u3044\u3046\u4e3b\u5f35\u3068\u306f\u76f8\u53cd\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002
\n\u4e0a\u8a18\u306e\u3088\u3046\u306b\u5b66\u3068\u307f\u5b50\u69d8\u306fReviewer 2 \u306e\u3000\u30b3\u30e1\u30f3\u30c810\uff09\u3092\u6a5f\u68b0\u7ffb\u8a33\u3057\u305f\u7d50\u679c\u306e\u307f\u63d0\u793a\u3057\u3066\u8003\u3048\u3092\u793a\u3057\u3066\u3044\u307e\u305b\u3093\u3002\u81ea\u5206\u306e\u8003\u3048\u3092\u62ab\u9732\u3059\u308b\u3053\u3068\u306a\u304f\u4ed6\u4eba\u306b\u610f\u898b\u3092\u6c42\u3081\u308b\u3068\u306f\u975e\u793c\u3060\u3068\u601d\u3044\u307e\u305b\u3093\u304b\uff1f\u5b66\u3068\u307f\u5b50\u30af\u30ea\u30cb\u30c3\u30af\u3067\u306f\u60a3\u8005\u3055\u3093\u3078\u306e\u5bfe\u5fdc\u304c\u3053\u308c\u3068\u3069\u3063\u3053\u3044\u3069\u3063\u3053\u3044\u306a\u3093\u3067\u3057\u3087\u3046\u306d\u3002\u306a\u306b\u305b\u4e0a\u304b\u3089\u76ee\u7dda\u306e\u30b3\u30df\u30e5\u30cb\u30b1\u30fc\u30b7\u30e7\u30f3\u80fd\u529b\u306b\u9577\u3051\u3066\u3044\u308b\u65b9\u3067\u3059\u304b\u3089\u306d\u3002
\n\u306f\u3044\u3001\u7b54\u3048\u307e\u3057\u305f\u3002\u4eca\u5ea6\u306f\u5b66\u3068\u307f\u5b50\u69d8\u304c\u8cea\u554f\u306b\u7b54\u3048\u308b\u756a\u3067\u3059\u3002
\n\uff11\uff09TCR\u518d\u69cb\u6210\u306b\u3064\u3044\u3066\u300c\u5207\u308a\u53d6\u3089\u308c\u305f\u3089\u907a\u4f1d\u5b50\u304c\u3064\u306a\u304c\u3089\u306a\u304f\u306a\u308b\u300d\u3068\u3044\u3046\u3053\u3068\u3092\u5f53\u65b9\u304c\u8a00\u3063\u305f\u3053\u3068\u304c\u306a\u3044\u306e\u306f\u8a8d\u3081\u305f\u306e\u3001\u8a8d\u3081\u306a\u3044\u306e\uff1f\u8a8d\u3081\u306a\u3044\u306e\u306a\u3089\u3001\u8a00\u3063\u305f\u3068\u3044\u3046\u8a3c\u62e0\u3092\u63d0\u793a<\/strong>\u304f\u3060\u3055\u3044\u3002
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