{"id":10204,"date":"2017-09-09T14:17:43","date_gmt":"2017-09-09T05:17:43","guid":{"rendered":"http:\/\/seigi.accsnet.ne.jp\/sigh\/blog\/?p=10204"},"modified":"2021-12-24T12:03:27","modified_gmt":"2021-12-24T03:03:27","slug":"20170907-%ef%bc%9a%e6%84%8f%e8%a6%8b%e6%9b%b8%e3%83%bb%e6%89%8b%e7%b6%9a%e8%a3%9c%e6%ad%a3%e6%9b%b8","status":"publish","type":"post","link":"https:\/\/nbsigh2.com\/?p=10204","title":{"rendered":"2017\/09\/07 \uff1a\u610f\u898b\u66f8\u30fb\u624b\u7d9a\u88dc\u6b63\u66f8"},"content":{"rendered":"<p><a href=\"https:\/\/nbsigh2.com\/?p=10109&amp;cpage=1#comment-8618\" target=\"_blank\" rel=\"noopener\">\u8ed2\u4e0b\u7ba1\u7406\u4eba\u3055\u3093\u306b\u77e5\u3089\u305b\u3066<\/a>\u3082\u3089\u3063\u305f\u306e\u3060\u304c\u3001\u7de0\u5207\u9593\u969b\u306b\u306a\u3063\u3066\u3000\u00a02017\/09\/07 \uff1a\u610f\u898b\u66f8\u3001\u30002017\/09\/07 \uff1a\u624b\u7d9a\u88dc\u6b63\u66f8 \u304c\u63d0\u51fa\u3055\u308c\u305f\u3002<br \/>\nSTAP\u7d30\u80de\u306e\u7279\u8a31\u7533\u8acb\u304c\u62d2\u7d76\uff082017\/03\/07 \uff1a\u62d2\u7d76\u7406\u7531\u901a\u77e5\u66f8\u00a0\uff09\u3055\u308c\u305f\u306e\u3060\u304c\u3001\u4e0d\u670d\u3067\uff12\u56de\u306e\u4e0d\u670d\u7533\u3057\u7acb\u3066\u5ef6\u9577\u304c\u884c\u308f\u308c\u6700\u7d42\u671f\u9650\u306e\uff16\u30f6\u6708\u7d4c\u904e\u3057\u305f\u306e\u3060\u3002<br \/>\n<a href=\"https:\/\/www.j-platpat.inpit.go.jp\/web\/tokujitsu\/pfwj\/PFWJ_GM401_Top.action\" target=\"_new\" rel=\"noopener\">\u7279\u8a31\u60c5\u5831\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u5be9\u67fb\u66f8\u985e\u60c5\u5831\u7167\u4f1a<\/a>\u306b<br \/>\n\u756a\u53f7\uff1a2015-509109\u3000\u3092\u5165\u529b\u3059\u308b\u3068\u898b\u3048\u308b\u3002<br \/>\n\u4ee5\u4e0b\u306e\u3088\u3046\u306b\u5358\u7d14\u5316\u3059\u308b\u3068\u3001\u307e\u305f\u6012\u308b\u4eba\u304c\u3067\u3066\u304f\u308b\u3060\u308d\u3046\u3051\u3069\u3001\u3056\u3063\u3068\u8aad\u3093\u3060\u7d50\u679c\u306f\u4ee5\u4e0b\u306e\u3088\u3046\u3060\u3002<br \/>\n\u6700\u521d\u306e\u7533\u8acb\u306f\u3001\u00a0\u300c\u7d30\u80de\u3092\u30b9\u30c8\u30ec\u30b9\u306b\u4f9b\u3059\u308b\u5de5\u7a0b\u3092\u542b\u3080\u3001\u591a\u80fd\u6027\u7d30\u80de\u3092\u751f\u6210\u3059\u308b\u65b9\u6cd5\u300d\u3067\u3042\u308b\u3002\u591a\u80fd\u6027\u7d30\u80de\u3092\u4f5c\u308b\u65b9\u6cd5\u306f\u3001\u7533\u8acb\u8005\u306e\u8ad6\u6587\u306f\u64a4\u56de\u3055\u308c\u305f\u3057\u3001\u7533\u8acb\u8005\u81ea\u8eab\u3082\u518d\u73fe\u3067\u304d\u306a\u3044\u3093\u3060\u304b\u3089\u3001\u7279\u8a31\u306b\u306a\u308b\u308f\u3051\u304c\u306a\u3044\u3067\u3057\u3087\u3068\u62d2\u7d76\u3055\u308c\u305f\u306e\u3060\u3002\u3053\u308c\u3092\u300cATP\u3067\u57f9\u990a\u6db2\u3092pH\u30925.4\u301c5.8\u306b\u3059\u308b\u5de5\u7a0b\u3067Oct4\u907a\u4f1d\u5b50\u3092\u767a\u73fe\u3059\u308b\u7d30\u80de\u306e\u88fd\u9020\u65b9\u6cd5\u300d\u3068\u6539\u8a02\u3057\u3066\u4e0d\u670d\u7533\u7acb\uff0f\u518d\u7533\u8acb\u3057\u305f\u306e\u3060\u3002<br \/>\n\u5be9\u67fb\u54e1\u304c\u62d2\u7d76\u306e\u969b\u5f15\u7528\u3057\u305f<a href=\"https:\/\/www.nature.com\/articles\/srep28003\" target=\"_blank\" rel=\"noopener\">Hitoshi\u00a0Niwa \u8ad6\u6587<\/a>\u3067Oct4\u907a\u4f1d\u5b50\u3092\u767a\u73fe\u3059\u308b\u7d30\u80de\u304c\u518d\u73fe\u3055\u308c\u3066\u3044\u308b\u304b\u3089\u3044\u3044\u3067\u3057\u3087\u3068\u3044\u3046\u306e\u304c\u7406\u7531\u3060\uff08\u3061\u306a\u307f\u306b\u7279\u8a31\u5e81\u306e\u5be9\u67fb\u54e1\u3082\u7533\u8acb\u8005\u3082Hitoshi\u00a0Niwa, et al,\u3068\u3057\u3066\u3044\u308b\u304cHitoshi\u00a0Niwa\u306e\u5358\u8457\u8ad6\u6587\u3060\uff09\u3002<br \/>\n\u591a\u80fd\u6027\u7d30\u80de\u3092\u3064\u304f\u308b\u306e\u306f\u3042\u304d\u3089\u3081\u3066\u3001\u5869\u9178\u306a\u3069\u306e\u5358\u7d14\u306a\u9178\u6027\u7269\u8cea\u3067\u306f\u306f\u306a\u304fATP\u306b\u3088\u3063\u3066\u3068\u9650\u5b9a\u3057\u3066pH5.4\u301c5.8\u3068\u3044\u3046\u6975\u3081\u3066\u72ed\u3044\u7bc4\u56f2\u306b\u9650\u5b9a\u3057\u305f\u57f9\u990a\u6db2\u3067Oct4\u767a\u73fe\u7d30\u80de\u3060\u3051\u3092\u4f5c\u308b\u65b9\u6cd5\u3068\u3044\u3046\u3053\u3068\u306b\u7533\u8acb\u3092\u5909\u3048\u3061\u3083\u3063\u305f\u308f\u3051\u3060\u3002\u3053\u308c\u3063\u3066\u3001\u7279\u8a31\u306e\u610f\u5473\u304c\u3042\u308b\u304b\uff1f\u591a\u80fd\u6027\u3092\u5f15\u3063\u8fbc\u3081\u3061\u3083\u3063\u305f\u306e\u3060\u3002<br \/>\n\u30b9\u30c8\u30ec\u30b9\u3092\u4e0e\u3048\u3066\u3001\u6b7b\u306b\u305d\u3046\u306b\u306a\u3063\u305f\u3089\u3001Oct4\u3068\u9650\u3089\u305a\u3001\u306a\u3093\u3067\u3082\u7121\u79e9\u5e8f\u306b\u767a\u73fe\u3055\u308c\u3061\u3083\u3046\u3060\u3051\u3060\u308d\u3002\u305d\u3093\u306a\u7d30\u80de\u306f\u5f79\u306b\u305f\u305f\u306a\u3044\u3002\u610f\u5473\u306e\u3042\u308bOct4\u306e\u767a\u73fe\u3067\u306a\u3044\u3068\u7279\u8a31\u3068\u3057\u3066\u306e\u610f\u7fa9\u306f\u306a\u3044\u3002<br \/>\n\u591a\u80fd\u6027\u7d30\u80de\u304c\u3067\u304d\u306a\u3051\u308c\u3070\u610f\u5473\u306e\u306a\u3044\u7279\u8a31\u3060\u3063\u305f\u306f\u305a\u3067\u3001\u306a\u306b\u304b\u3001\u3068\u3082\u304b\u304f\u7279\u8a31\u3092\u6210\u7acb\u3057\u305f\u3068\u3044\u3046\u5b9f\u7e3e\u3092\u4f5c\u308b\u305f\u3081\u3060\u3051\u306a\u3093\u3060\u308d\u3046\u306d\u3002<br \/>\n\u8ed2\u4e0b\u7ba1\u7406\u4eba\u3055\u3093\u306e\u304a\u3063\u3057\u3083\u308b\u3068\u304a\u308a\u3001\u3053\u308c\u304c\u307e\u305f\u64c1\u8b77\u306e\u9023\u4e2d\u304c\u7b46\u982d\u8457\u8005\u62c5\u5f53\u90e8\u5206\u304c\u7279\u8a31\u7533\u8acb\u3055\u308c\u305f\u3068\u9a12\u3050\u3053\u3068\u306b\u306a\u308b\u3093\u3060\u308d\u3046\u306d\u3002teabreake\u6c0f\u306f\u3069\u3046\u3044\u3046\u30b3\u30e1\u30f3\u30c8\u3059\u308b\u3093\u3060\u308d\u3046\u306d\u3002\u3053\u3046\u3044\u3046\u3053\u3068\u306b\u3053\u3060\u308f\u3063\u3066\u3044\u308b\u65b9\u306e\u3088\u3046\u3060\u304b\u3089\u3002<br \/>\n\u3061\u306a\u307f\u306b\u88dc\u6b63\u66f8\u306e\u5185\u5bb9\u306f\uff1b<\/p>\n<blockquote><p>\u25cf\u3000\u7d30\u80de\u3092\u3001\u4f4e\uff50\uff28\u30b9\u30c8\u30ec\u30b9\u306b\u4f9b\u3059\u308b\u5de5\u7a0b\u3092\u542b\u3080\u3001\uff2f\uff43\uff54\uff14\u3092\u767a\u73fe\u3059\u308b\u7d30\u80de\u3092\u542b\u6709\u3059\u308b\u7d30\u80de\u584a\u3092\u751f\u6210\u3059\u308b\u65b9\u6cd5\u3067\u3042\u3063\u3066\u3001\u8a72\u4f4e\uff50\uff28\u304c\u3001\uff15\uff0e\uff14\uff5e\uff15\uff0e\uff18\u306e\uff50\uff28\u3067\u3042\u308a\u3001\u4e14\u3064\u3001\uff50\uff28\u306e\u8abf\u6574\u304c\uff21\uff34\uff30\u3092\u7528\u3044\u3066\u884c\u308f\u308c\u308b\u3053\u3068\u3092\u7279\u5fb4\u3068\u3059\u308b\u3001\u65b9\u6cd5\u3002<br \/>\n\u25cf\u3000\u7d30\u80de\u584a\u304c\u5916\u6765\u907a\u4f1d\u5b50\u3001\u8ee2\u5199\u7269\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u3001\u6838\u6210\u5206\u3082\u3057\u304f\u306f\u7d30\u80de\u8cea\u306e\u5c0e\u5165\u306a\u3057\u306b\u3001\u307e\u305f\u306f\u7d30\u80de\u878d\u5408\u306a\u3057\u306b\u751f\u6210\u3055\u308c\u308b<br \/>\n\u25cf\u3000\u7d30\u80de\u304c\u7d44\u7e54\u306e\u90e8\u5206\u3068\u3057\u3066\u5b58\u5728\u3057\u306a\u3044\u3001<br \/>\n\u25cf\u3000\u7d30\u80de\u304c\u4f53\u7d30\u80de\u3001\u5e79\u7d30\u80de\u3001\u524d\u99c6\u7d30\u80de\u307e\u305f\u306f\u80da\u7d30\u80de\u3067\u3042\u308b\u3001<br \/>\n\u25cf\u3000\u7d30\u80de\u304c\u5358\u96e2\u3055\u308c\u305f\u7d30\u80de\u3067\u3042\u308b\u3001<br \/>\n\u25cf\u3000\u7d30\u80de\u304c\u7d30\u80de\u306e\u4e0d\u5747\u4e00\u306a\u96c6\u56e3\u4e2d\u306b\u5b58\u5728\u3059\u308b\u3001<br \/>\n\u25cf\u3000\u7d30\u80de\u304c\u7d30\u80de\u306e\u5747\u4e00\u306a\u96c6\u56e3\u4e2d\u306b\u5b58\u5728\u3059\u308b\u3001<br \/>\n\u25cf\u3000\u7d30\u80de\u304c\uff12\uff5e\uff13\u65e5\u9593\u66dd\u9732\u3055\u308c\u308b\u3001<br \/>\n\u25cf\u3000\u7d30\u80de\u304c\uff11\u65e5\u9593\u4ee5\u4e0b\u66dd\u9732\u3055\u308c\u308b\u3001<br \/>\n\u25cf\u3000\u7d30\u80de\u304c\uff11\u6642\u9593\u4ee5\u4e0b\u66dd\u9732\u3055\u308c\u308b\u3001<br \/>\n\u25cf\u3000\u7d30\u80de\u304c\u7d04\uff13\uff10\u5206\u9593\u66dd\u9732\u3055\u308c\u308b\u3001<br \/>\n\u25cf\u3000\u7d30\u80de\u304c\u54fa\u4e73\u52d5\u7269\u7d30\u80de\u3067\u3042\u308b\u3001<br \/>\n\u25cf\u3000\u7d30\u80de\u304c\u30d2\u30c8\u7d30\u80de\u3067\u3042\u308b\u3001<br \/>\n\u25cf\u3000\u7d30\u80de\u304c\u6210\u4f53\u7d30\u80de\u3001\u65b0\u751f\u5150\u7d30\u80de\u3001\u80ce\u5150\u7d30\u80de\u3001\u7f8a\u6c34\u7d30\u80de\u3001\u307e\u305f\u306f\u81cd\u5e2f\u8840\u7d30\u80de\u3067\u3042\u308b\u3001<br \/>\n\u25cf\u3000\u7d30\u80de\u584a\u3092\u30a4\u30f3\u30d3\u30c8\u30ed\u3067\u7dad\u6301\u3059\u308b\u5de5\u7a0b\u3092\u3055\u3089\u306b\u542b\u3080\u3001<br \/>\n\u25cf\u3000\u7d30\u80de\u306e\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u72b6\u614b\u304c\u80da\u6027\u5e79\u7d30\u80de\u306e\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u72b6\u614b\u306b\u3088\u308a\u8fd1\u304f\u985e\u4f3c\u3059\u308b\u3088\u3046\u306b\u5909\u5316\u3055\u305b\u3089\u308c\u308b\u3001<br \/>\n\u25cf\u3000\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u72b6\u614b\u304c\u30e1\u30c1\u30eb\u5316\u30d1\u30bf\u30fc\u30f3\u3092\u542b\u3080\u3001<br 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